公开(公告)号：US20140217031A1

公开(公告)日：2014-08-07

申请号：US14125957

申请日：2012-06-15

申请人： Ziqiang Wang ,  Steve Zulli ,  Daniel Rolle ,  Chuping Luo ,  Harbaksh Sidhu

发明人： Ziqiang Wang ,  Steve Zulli ,  Daniel Rolle ,  Chuping Luo ,  Harbaksh Sidhu

IPC分类号： B01D15/16

CPC分类号： B01D15/165 ,  B01D15/24 ,  B01D15/247 ,  B01D15/40 ,  G01N30/62 ,  G01N30/80 ,  G01N30/82 ,  G01N2030/027

摘要： A supercritical fluid chromatography system comprises a first pump for pumping a first flow stream comprising a compressible fluid and a second pump for pumping a second flow stream comprising a modifier fluid. The second pump is in parallel with the first pump. A column is located in a combined flow stream. The column is located downstream of the first and second pumps. The combined flow stream comprises the first flow stream, the second flow stream, and a sample. A detector is located downstream of the column. A gas-liquid separator is located downstream of the detector. The gas-liquid separator is configured to vent a majority of the compressible fluid while maintaining a majority of the sample, thus preventing aerosolization of the flow stream and minimizing sample loss as well as cross contamination. An open bed collector is located after the gas-liquid separator.

摘要翻译： 超临界流体色谱系统包括用于泵送包含可压缩流体的第一流动流的第一泵和用于泵送包含改性剂流体的第二流动流的第二泵。 第二个泵与第一个泵并联。 一列位于组合的流动流中。 该柱位于第一和第二泵的下游。 组合的流动流包括第一流动流，第二流动流和样品。 检测器位于柱的下游。 气液分离器位于检测器的下游。 气液分离器被配置为排出大部分可压缩流体，同时保持样品的大部分，从而防止流动物流的雾化，并最小化样品损失以及交叉污染。 开式床收集器位于气液分离器之后。

公开(公告)号：US09731219B2

公开(公告)日：2017-08-15

申请号：US14125957

申请日：2012-06-15

申请人： Ziqiang Wang ,  Steven L. Zulli ,  Daniel Rolle ,  Chuping Luo ,  Harbaksh Sidhu

发明人： Ziqiang Wang ,  Steven L. Zulli ,  Daniel Rolle ,  Chuping Luo ,  Harbaksh Sidhu

IPC分类号： B01D15/40 ,  B01D15/16 ,  B01D15/24 ,  G01N30/80 ,  G01N30/62 ,  G01N30/82 ,  G01N30/02

CPC分类号： B01D15/165 ,  B01D15/24 ,  B01D15/247 ,  B01D15/40 ,  G01N30/62 ,  G01N30/80 ,  G01N30/82 ,  G01N2030/027

摘要： A supercritical fluid chromatography system comprises a first pump for pumping a first flow stream comprising a compressible fluid and a second pump for pumping a second flow stream comprising a modifier fluid. The second pump is in parallel with the first pump. A column is located in a combined flow stream. The column is located downstream of the first and second pumps. The combined flow stream comprises the first flow stream, the second flow stream, and a sample. A detector is located downstream of the column. A gas-liquid separator is located downstream of the detector. The gas-liquid separator is configured to vent a majority of the compressible fluid while maintaining a majority of the sample, thus preventing aerosolization of the flow stream and minimizing sample loss as well as cross contamination. An open bed collector is located after the gas-liquid separator.

公开(公告)号：US20140230528A1

公开(公告)日：2014-08-21

申请号：US14125956

申请日：2012-06-15

申请人： Ziqiang Wang ,  Chuping Luo ,  Harbaksh Sidhu

发明人： Ziqiang Wang ,  Chuping Luo ,  Harbaksh Sidhu

IPC分类号： B01D15/18 ,  G01N30/16

CPC分类号： B01D15/18 ,  B01D15/40 ,  B01F5/0691 ,  B01F5/0696 ,  B01F2215/0037 ,  G01N30/16 ,  G01N30/28 ,  G01N30/38 ,  G01N2030/347 ,  G01N2030/387 ,  G01N2030/528 ,  G01N30/02

摘要： A mixing device for use in a chromatography system, the device includes an exterior housing having a first end and a second end and a hydraulic flow connector at the first end of the exterior housing. A cartridge including a chamber is enclosed within the exterior housing. The chamber has at least one wall defining an interior volume having a shape, wherein the shape of the interior volume creates a turbulent flow condition to mix at least two fluids and provide flow through the cartridge during operation of the chromatography system. The chamber also retains the sample, thereby ensuring that the sample is focused in the chamber such that a more narrow bolus of sample enters the chromatography column.

摘要翻译： 一种用于色谱系统的混合装置，该装置包括具有第一端和第二端的外部壳体以及在外部壳体的第一端处的液压流动连接器。 包括腔室的盒被封装在外壳内。 腔室具有限定具有形状的内部容积的至少一个壁，其中内部容积的形状产生湍流条件以混合至少两种流体并且在色谱系统操作期间提供通过筒的流动。 室还保留样品，从而确保样品聚焦在室中，使得更窄的样品进入色谱柱。