公开(公告)号：US06587617B2

公开(公告)日：2003-07-01

申请号：US09791092

申请日：2001-02-22

Applicant: Zonh-Zen Ho

Inventor： Zonh-Zen Ho

IPC: G02B628

CPC classification number: G01N21/253 ,  G01N2201/1085 ,  G02B6/4249

Abstract: An apparatus and method for imaging biochip spots in which a linearly spaced array of micro-lenses has a set of optical fibers which are associated with each micro-lens to receive and transmit the image magnified by the micro-lens. The micro-lenses are spaced to that of the biochip spots so that the microlens array can be positioned over a selected group of biochip spots, one for each micro-lens. The microlens array can be translated to be over selected groups of biochip spots. A detector and user devise such as a computer and a screen are used to record and view the collected images.

公开(公告)号：US6040171A

公开(公告)日：2000-03-21

申请号：US138240

申请日：1998-08-21

Applicant: Zonh-Zen Ho ,  Tomasz P. Jannson ,  Robert A. Lieberman ,  Gajendra D. Savant ,  Allan Wang

Inventor： Zonh-Zen Ho ,  Tomasz P. Jannson ,  Robert A. Lieberman ,  Gajendra D. Savant ,  Allan Wang

IPC: C12M1/00 ,  C12M3/00

CPC classification number: C12M23/12

Abstract: Apparatus for analyzing biological samples includes a unique surface which promotes adhesion, growth and optical analysis of samples. The unique surface is formed at the bottom of each well of a microplate and provides increased surface area with a distribution of features operative also to shape and redirect light used to sense test results. The unique surface may be used in forms such as a monolith, a microplate, a chamber, a flask and others.

Abstract translation: 用于分析生物样品的装置包括促进样品的粘附，生长和光学分析的独特表面。 独特的表面形成在微板的每个孔的底部，并且提供增加的表面积，其特征分布也用于形成和重定向用于感测测试结果的光。 独特的表面可以以诸如整料，微板，室，烧瓶等形式使用。

公开(公告)号：US5660181A

公开(公告)日：1997-08-26

申请号：US354317

申请日：1994-12-12

Applicant: Zonh-Zen Ho ,  Taiwei Lu

Inventor： Zonh-Zen Ho ,  Taiwei Lu

IPC: A61B5/00 ,  A61B6/02

CPC classification number: A61B5/7264 ,  A61B1/00193 ,  A61B1/042 ,  A61B1/043 ,  A61B1/07 ,  A61B5/0059 ,  A61B5/7267 ,  Y10S128/925

Abstract: An apparatus for in-depth three dimensional tumor mapping including (A) a light source; (B) a multi-fiber bundle including at least one illumination fiber and at least two receiving fibers, the at least one illumination fiber being connected to the light source; (C) a spectrometer connected to the at least two receiving fibers; and (D) a hybrid neural network connected to the spectrometer, said hybrid neural network including a principle component analysis processor and a neural network classifier.

Abstract translation: 一种用于深入三维肿瘤图谱的装置，包括（A）光源; （B）包括至少一个照明光纤和至少两个接收光纤的多纤维束，所述至少一个照明光纤连接到所述光源; （C）连接到所述至少两个接收光纤的光谱仪; 和（D）连接到光谱仪的混合神经网络，所述混合神经网络包括主成分分析处理器和神经网络分类器。