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公开(公告)号：US20150266963A1
公开(公告)日：2015-09-24
申请号：US14626038
申请日：2015-02-19
申请人： arGEN-X N.V.
发明人： Karen SILENCE , Peter ULRICHTS , Johannes Joseph Wilhelmus DE HAARD , Torsten DREIER , Michael John Scott SAUNDERS , Harald WAJANT , Sofie Maria Elvire GABRIELS , Mahan MOSHIR
IPC分类号： C07K16/28
CPC分类号： C07K16/2875 , A61K2039/505 , C07K16/2878 , C07K2317/22 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to antibodies and antigen binding fragments thereof which bind to the human CD70 protein with high affinity and display potent inhibition of tumour cell growth.
摘要翻译： 本发明涉及以高亲和力结合人CD70蛋白的抗体及其抗原结合片段，并显示对肿瘤细胞生长的有效抑制。
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公开(公告)号：US20170369581A9
公开(公告)日：2017-12-28
申请号：US14626038
申请日：2015-02-19
申请人： arGEN-X N.V.
发明人： Karen SILENCE , Peter ULRICHTS , Johannes Joseph Wilhelmus DE HAARD , Torsten DREIER , Michael John Scott SAUNDERS , Harald WAJANT , Sofie Maria Elvire GABRIELS , Mahan MOSHIR
CPC分类号： C07K16/2875 , A61K2039/505 , C07K16/2878 , C07K2317/22 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to antibodies and antigen binding fragments thereof which bind to the human CD70 protein with high affinity and display potent inhibition of tumour cell growth.
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公开(公告)号：US20170145088A1
公开(公告)日：2017-05-25
申请号：US15365569
申请日：2016-11-30
申请人： arGEN-X N.V.
CPC分类号： C07K16/245 , C07K16/461 , C07K16/467 , C07K2317/22 , C07K2317/24 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The invention relates to novel humanized antibodies derived from the conventional antibody repertoire of species in the family Camelidae.
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公开(公告)号：US20180016351A1
公开(公告)日：2018-01-18
申请号：US15718984
申请日：2017-09-28
申请人： ARGEN-X N.V.
CPC分类号： C07K16/4241 , B01D15/1864 , B01D15/3809 , C07K16/00 , C07K16/2863 , C07K16/4208 , C07K16/4266 , C07K2317/14 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C12N15/1055 , G01N33/686
摘要： The present invention is concerned with antigen binding polypeptides, and in particular conventional antibodies derived from camelid species, that specifically bind to target antigens that are either self-antigens or highly conserved antigens. The present invention also relates to anti-idiotype antigen binding peptides which bind to a target antigen comprising the variable region of an antibody obtained from a species within the family Camelidae.
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公开(公告)号：US20170342166A1
公开(公告)日：2017-11-30
申请号：US15503602
申请日：2015-08-20
申请人： ARGEN-X N.V.
CPC分类号： C07K16/468 , C07K1/22 , C07K16/42 , C07K2317/22 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/526 , C07K2317/569 , C07K2317/64
摘要： The present invention relates to multispecific antibodies, for example bispecific antibodies, and methods for the isolation or purification of the same. The antibodies of the invention comprise first and second heavy chain-light chain pairings wherein each pairing comprises a distinct selective recognition site including one or more amino acid residues contributed from the heavy chain and the light chain of the pairing. The first and second selective recognition sites differ by at least one amino acid residue and can be differentially bound by first and second selective recognition agents according to the methods of the invention. Such methods facilitate the production of antibody preparations enriched for multispecific antibodies having the correct functional heavy chain-light chain pairings.
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