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    Use of 2,5-dihydroxybenzenesulfonic acid in the manufacturing of medicines, applicable to the treatment of angiodependent diseases
    4.
    发明授权
    Use of 2,5-dihydroxybenzenesulfonic acid in the manufacturing of medicines, applicable to the treatment of angiodependent diseases 有权
    2,5-二羟基苯磺酸在制造药物中的应用，适用于治疗依从性疾病

    公开(公告)号：US08435971B2

    公开(公告)日：2013-05-07

    申请号：US13169781

    申请日：2011-06-27

    申请人： Pedro Cuevas Sánchez ,  Antonio Romero Garrido ,  Guillermo Gimenez Gallego ,  Serafin Valverde Lopez ,  Rosa Maria Lozano Puerto

    发明人： Pedro Cuevas Sánchez ,  Antonio Romero Garrido ,  Guillermo Gimenez Gallego ,  Serafin Valverde Lopez ,  Rosa Maria Lozano Puerto

    IPC分类号： A61K31/185 ,  A61K31/56 ,  A01N37/00 ,  A01N45/00

    CPC分类号： A61K31/185

    摘要： The invention relates to the use of 2,5-dihydroxybenzenesulfonic acid in the production of medicaments for the treatment of angiodependent diseases. More specifically, the invention relates to the use of the aforesaid compound and, in particular, the calcium and potassium salts thereof, for the treatment of two angiodependent diseases, which present a reduction in the apoptosis, namely cancer and psoriasis. The invention also discloses the antiproliferative, antimigratory, antiangiogenic and proapoptotic capacity of said family of compounds in non-quiescent cells. In addition, the invention details the potentiating effect of said compounds on known cytostatic medicines in the treatment of tumours and, specifically, on gliomas. The invention further relates to the therapeutic efficacy of said compounds, based on the combined antiproliferative, antiangiogenic and proapaptotic capacities thereof, in the treatment of chronic psoriatic plaques.

    摘要翻译： 本发明涉及2,5-二羟基苯磺酸在制备用于治疗依赖性疾病的药物中的用途。 更具体地，本发明涉及上述化合物，特别是其钙和钾盐用于治疗呈现细胞凋亡降低（即癌症和牛皮癣）的两种血液依赖性疾病的用途。 本发明还公开了所述家族化合物在非静止细胞中的抗增殖，抗微生物，抗血管生成和促凋亡能力。 此外，本发明详细描述了所述化合物对已知的细胞生长抑制药物在治疗肿瘤中，特别是胶质瘤的增强作用。 本发明进一步涉及所述化合物在治疗慢性银屑病斑块的基础上结合抗增生性，抗血管生成和促血细胞生成能力的治疗功效。