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公开(公告)号：US20240308965A1
公开(公告)日：2024-09-19
申请号：US18493441
申请日：2023-10-24
发明人： Donglei LIU , Julien PAPILLON , Stefan PEUKERT , James J. POWERS
IPC分类号： C07D217/02 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D217/02 , C07D401/12 , C07D405/12 , C07D417/12
摘要： Provided herein are compounds and pharmaceutical compositions useful for treating diseases or disorders mediated by the TRPV1 receptor. The present invention also provides methods for treating ocular diseases or disorders by administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I) or a pharmaceutical composition described herein.
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公开(公告)号：US20240302569A1
公开(公告)日：2024-09-12
申请号：US18422180
申请日：2024-01-25
CPC分类号： G02B1/043 , B29D11/00038 , G02C7/049
摘要： A method for preparing a contact lens containing an ultraviolet (UV) blocker is disclosed. The method involves (a) polymerizing a monomeric mixture comprising (i) one or more contact lens-forming comonomers, and (ii) one or more UV blockers comprising a phenolic group having a protected hydroxyl moiety and one or more ethylenically unsaturated reactive groups to obtain a polymerization product comprising the one or more UV blockers comprising a phenolic group having a protected hydroxyl moiety, and (b) deprotecting the protected hydroxyl moiety of the one or more UV blockers of the polymerization product.
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公开(公告)号：US20240277895A1
公开(公告)日：2024-08-22
申请号：US18414854
申请日：2024-01-17
发明人： Walter Laredo , Borui Zhang , Jeffrey Linhardt
IPC分类号： A61L27/16 , A61L27/50 , C08F120/18
CPC分类号： A61L27/16 , A61L27/50 , C08F120/18 , A61L2430/16
摘要： An ophthalmic device which is a polymerization product of a monomeric mixture includes (a) from about 30 to about 75 weight percent, based on the total weight of the monomeric mixture, of one or more cycloaliphatic (meth)acrylic monomers; (b) greater than about 25 weight percent, based on the total weight of the monomeric mixture, of one or more hydrophilic monomers; and (c) one or more crosslinking agents, wherein the ophthalmic device has a refractive index of about 1.48 to about 1.52 and an Abbe number greater than or equal to 50.
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公开(公告)号：US20240270419A1
公开(公告)日：2024-08-15
申请号：US18632600
申请日：2024-04-11
发明人： Alok K. Awasthi , Jade J. Russell , Mark R. Mis
CPC分类号： B65B25/008 , A45C11/005 , B65B55/04 , B65D85/54 , B65D2585/545
摘要： A packaging system for the storage of an ophthalmic device is disclosed. The packaging system includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution that includes ectoine or an ophthalmologically acceptable ectoine derivative. The aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is sterilized.
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公开(公告)号：US12048647B2
公开(公告)日：2024-07-30
申请号：US17147196
申请日：2021-01-12
CPC分类号： A61F9/0008 , B05B1/086 , B05B9/0838 , B65D1/095
摘要： Fluid delivery devices and methods are described, where the device may comprise a piezoelectric actuator operatively coupled to an ampoule with fluid, under a preloading force. The ampoule may comprise a thin-walled thermoplastic package which includes one or more apertures positioned on the wall of the ampoule. The piezoelectric actuator may be configured to clamp at least partially around the circumference of the ampoule and apply oscillations to its wall. The oscillations, typically in ultrasonic frequency, produce cycles of acoustic pressure in the fluid, leading to ejection of the fluid droplets or streams from the apertures.
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6.发明公开公开(公告)号：US20240208685A1
公开(公告)日：2024-06-27
申请号：US18145217
申请日：2022-12-22
发明人： Geoffrey Spencer
CPC分类号： B65B25/008 , B65B55/22 , B65B61/00 , B65D81/22 , B65D85/54 , B65D2585/545
摘要： A method of selectively controlling movement of a contact lens in blister packaging comprising a cavity, the method comprising depositing an electric charge at a location in the cavity, securing the contact lens to the blister packaging at the location with the electric charge, and after the step of securing the contact lens, injecting a lens hydrating liquid into the cavity whereby the lens is hydrated and the securing terminated. A method of selectively controlling movement of a contact lens in blister packaging comprising a cavity, the method comprising depositing a droplet of a first lens hydrating liquid in the cavity, securing the contact lens to the blister packaging with the droplet, and after the step of securing the contact lens, injecting a second lens hydrating liquid into the cavity whereby the lens is hydrated.
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公开(公告)号：US12012238B2
公开(公告)日：2024-06-18
申请号：US17714393
申请日：2022-04-06
发明人： Alok K. Awasthi , Jade J. Russell , Mark R. Mis
CPC分类号： B65B25/008 , A45C11/005 , B65B55/04 , B65D85/54 , B65D2585/545
摘要： A packaging system for the storage of an ophthalmic device is disclosed. The packaging system includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution that includes ectoine or an ophthalmologically acceptable ectoine derivative. The aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is sterilized.
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公开(公告)号：US20240165019A1
公开(公告)日：2024-05-23
申请号：US17991113
申请日：2022-11-21
IPC分类号： A61K9/00 , A61K31/728 , A61P27/04
CPC分类号： A61K9/0051 , A61K31/728 , A61P27/04
摘要： The present invention relates to methods for treating tear film deficiencies in the eye by applying to the eye or the surrounding area a composition comprising hyaluronic acid.
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公开(公告)号：US11944638B2
公开(公告)日：2024-04-02
申请号：US17691265
申请日：2022-03-10
发明人： Vicki Barniak , Catherine Scheuer , William T. Reindel , John Michael Duex , Andrea E. Siverling
IPC分类号： A61K31/728 , A01N33/12 , A01N37/52 , A01P1/00 , A61K9/00 , A61K47/02 , A61K47/10 , A61K47/26 , A61L12/14 , A61P27/04 , C11D1/66 , C11D1/722 , C11D3/00 , C11D3/04 , C11D3/20 , C11D3/22 , C11D3/48
CPC分类号： A61K31/728 , A01N33/12 , A01N37/52 , A01P1/00 , A61K9/0048 , A61K47/02 , A61K47/10 , A61K47/26 , A61L12/142 , A61L12/145 , A61P27/04 , C11D1/66 , C11D1/722 , C11D3/0078 , C11D3/046 , C11D3/2065 , C11D3/222 , C11D3/227 , C11D3/48
摘要： An ophthalmically compatible solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the ophthalmically compatible solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the ophthalmically compatible solution, of erythritol; (c) sodium chloride, potassium chloride or any combination thereof; and (d) one or more buffers.
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公开(公告)号：US11873361B2
公开(公告)日：2024-01-16
申请号：US17836282
申请日：2022-06-09
发明人： Alok Kumar Awasthi , Kristen Rae Hovinga , Emily Abrams Gabriel , Kevin Jacob DeRyke , Jade J. Russell , James Anthony DiBella, Jr. , Alana Ingham
IPC分类号： C08F283/06 , A61L27/16 , A61L27/50 , C08F226/10 , C08F283/12 , C08K5/18 , C08K5/42 , G02B1/04
CPC分类号： C08F283/06 , A61L27/16 , A61L27/50 , C08F226/10 , C08F283/12 , C08K5/18 , C08K5/42 , A61L2430/16 , G02B1/043
摘要： An ophthalmic device for slowing, inhibiting or preventing myopia progression which is a polymerization product of a monomeric mixture comprising (a) greater than 50 wt. %, based on the total weight of the monomeric mixture, of one or more non-silicone-containing hydrophilic monomers; (b) one or more crosslinking agents; and (c) one or more red-light blocking compounds blocking greater than 5% to about 25% of red-light transmission through the ophthalmic device at a wavelength of from about 550 nm to about 800 nm, wherein the one or more red-light blocking compounds have one or more ethylenically unsaturated reactive end groups.
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