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    MODIFIED RELEASE COMPOSITION OF AT LEAST ONE FORM OF VENLAFAXINE
    1.
    发明申请
    MODIFIED RELEASE COMPOSITION OF AT LEAST ONE FORM OF VENLAFAXINE 审中-公开
    至少一种芬替康的形式的改性释放组合物

    公开(公告)号：US20090258067A1

    公开(公告)日：2009-10-15

    申请号：US12425819

    申请日：2009-04-17

    Applicant: Fang ZHOU ,  Paul Maes ,  Steven Frisbee

    Inventor： Fang ZHOU ,  Paul Maes ,  Steven Frisbee

    IPC: A61K9/24 ,  A61K31/137

    CPC classification number: A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/284 ,  A61K9/2866

    Abstract: The present invention relates to a modified release composition of at least one form of venlafaxine, which is an enhanced absorption delayed controlled release composition. The composition comprises a core comprising at least one form of venlafaxine, less than 10% of a gelling agent and a pharmaceutically acceptable excipient. The composition further comprises a modified release coating which substantially surrounds the core which provides a delayed controlled release of the at least one form of venlafaxine.

    Abstract translation: 本发明涉及至少一种形式的文拉法辛的改进释放组合物，其是增强的吸收延迟控释组合物。 组合物包含包含至少一种形式的文拉法辛，小于10％的胶凝剂和药学上可接受的赋形剂的核心。 所述组合物还包含基本上围绕所述芯的改性释放涂层，其提供所述至少一种形式的文拉法辛的延迟控制释放。

    MODIFIED RELEASE COMPOSITION OF AT LEAST ONE FORM OF VENLAFAXINE
    5.
    发明申请
    MODIFIED RELEASE COMPOSITION OF AT LEAST ONE FORM OF VENLAFAXINE 审中-公开
    至少一种芬替康的形式的改性释放组合物

    公开(公告)号：US20080175873A1

    公开(公告)日：2008-07-24

    申请号：US11947883

    申请日：2007-11-30

    Applicant: Fang Zhou ,  Paul Maes ,  Steven Frisbee

    Inventor： Fang Zhou ,  Paul Maes ,  Steven Frisbee

    IPC: A61K9/00 ,  A61K31/137 ,  A61P25/24

    CPC classification number: A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/284 ,  A61K9/2866

    Abstract: The present invention relates to a modified release composition of at least one form of venlafaxine, which is an enhanced absorption delayed controlled release composition. The composition comprises a core comprising at least one form of venlafaxine, less than 10% of a gelling agent and a pharmaceutically acceptable excipient. The composition further comprises a modified release coating which substantially surrounds the core which provides a delayed controlled release of the at least one form of venlafaxine.

    Abstract translation: 本发明涉及至少一种形式的文拉法辛的改进释放组合物，其是增强的吸收延迟控释组合物。 组合物包含包含至少一种形式的文拉法辛，小于10％的胶凝剂和药学上可接受的赋形剂的核心。 所述组合物还包含基本上围绕所述芯的改性释放涂层，其提供所述至少一种形式的文拉法辛的延迟控制释放。

    Modified release formulations of tramadol and uses thereof
    7.
    发明申请
    Modified release formulations of tramadol and uses thereof 审中-公开
    曲马多的缓释制剂及其用途

    公开(公告)号：US20070184115A1

    公开(公告)日：2007-08-09

    申请号：US11640494

    申请日：2006-12-18

    Applicant: Salim Mamajiwalla ,  Steve Frisbee

    Inventor： Salim Mamajiwalla ,  Steve Frisbee

    IPC: A61K9/22 ,  A61K9/32 ,  A61K9/42

    CPC classification number: A61K9/0004 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2072 ,  A61K9/282 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/5047

    Abstract: The present invention relates to specific types of controlled and modified release dosage forms containing tramadol or at least one pharmaceutically acceptable salt, enantiomer, or metabolite thereof that possess specific pharmacokinetic properties and which desirably are not subject to dose dumping, e.g., induced by food or alcohol. The invention also relates to methods of making and using these controlled and modified release dosage forms in therapeutic regimens wherein tramadol is therapeutically effective.

    Abstract translation: 本发明涉及含有曲马多或其至少一种药学上可接受的盐，对映异构体或代谢物的具有特定类型的受控和释放剂型，其具有特定的药代动力学性质，并且其希望不经过剂量倾倒，例如由食物或 醇。 本发明还涉及在治疗方案中制备和使用这些受控和调节释放剂型的方法，其中曲马多是治疗有效的。

    QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON
    8.
    发明申请
    QUICK DISSOLVE COMPOSITIONS AND TABLETS BASED THEREON 审中-公开
    基于快速溶解组合物和片剂

    公开(公告)号：US20100178353A1

    公开(公告)日：2010-07-15

    申请号：US12730339

    申请日：2010-03-24

    Applicant: Naima MEZAACHE ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman

    Inventor： Naima MEZAACHE ,  Steven E. Frisbee ,  Patrick B. Woodall ,  Mark R. Herman

    IPC: A61K9/14 ,  A61K31/138 ,  A61K31/4525 ,  A61K31/437 ,  A61P25/24

    CPC classification number: A61K9/1635 ,  A61K9/0056 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/2081 ,  A61K9/5026 ,  A61K31/366 ,  A61K31/426

    Abstract: The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

    Abstract translation: 本发明提供了一种组合物，其可用于制备能够在少于40秒内溶解于口中的口服剂型，而不需要常规的超级崩解剂并具有小于1％的脆性; 其中所述组合物包括液体微粒和赋形剂。 根据本发明优选的赋形剂组合物包含直接可压缩的无机盐; 纤维素衍生物或直接可压缩的无机盐和纤维素衍生物的组合。 优选地，液体颗粒和赋形剂组合的比例使得当组合物被压缩以获得硬度为20至50N的剂型时，活性成分基本保持在微球内。本发明的组合物允许 制造具有改善的硬度和脆性的口服剂量。

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