公开(公告)号：US20070219132A1

公开(公告)日：2007-09-20

申请号：US11559285

申请日：2006-11-13

申请人： Seth Donahue

发明人： Seth Donahue

IPC分类号： A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/635 ,  A61K38/00 ,  C12N5/0654 ,  C12N2501/37

摘要： Black bear parathyroid hormone (PTH) and functional fragments thereof are provided. Also provided are methods of using black bear PTH and functional fragments for increasing cAMP in a bone-forming cell; reducing apoptosis in a bone-forming cell; decreasing the ratio of expression levels of Bax protein to Bcl-2 protein in a bone-forming cell; increasing the expression level of one or more of a bone matrix protein, a transcriptional activator, or a transcriptional regulator in a bone-forming cell; enhancing bone mineral density, increasing bone mass, decreasing bone loss, or reducing the incidence of bone fractures, or any combination thereof, in a subject; also provided are antibodies directed against black bear parathyroid hormone (PTH) and functional fragments thereof.

摘要翻译： 提供黑熊甲状旁腺激素（PTH）及其功能片段。 还提供了使用黑熊PTH和功能片段在骨形成细胞中增加cAMP的方法; 减少骨形成细胞凋亡; 降低骨形成细胞中Bax蛋白与Bcl-2蛋白的表达水平之比; 增加骨形成细胞中骨基质蛋白，转录激活子或转录调节子中的一种或多种的表达水平; 在受试者中增强骨矿物质密度，增加骨质量，减少骨丢失或减少骨折的发生率或其任何组合; 还提供针对黑熊甲状旁腺激素（PTH）的抗体及其功能片段。

公开(公告)号：US07183092B2

公开(公告)日：2007-02-27

申请号：US10954840

申请日：2004-09-30

申请人： Eileen H. Kim Choi ,  David R. Shonnard ,  Irina V. Rybina

发明人： Eileen H. Kim Choi ,  David R. Shonnard ,  Irina V. Rybina

IPC分类号： C12N9/02 ,  C12N1/21 ,  C12N5/06 ,  C12N15/63 ,  C07H21/04

CPC分类号： C12N9/0069 ,  C07H21/04 ,  C12Q1/66

摘要： The invention comprises modified luciferase proteins which are more resistant to inhibition by test chemicals than wild type luciferase. The modified luciferases also contain greater thermostability than wild type luciferase.

摘要翻译： 本发明包括对野生型荧光素酶更耐受测试化学物质的抑制的修饰的萤光素酶蛋白。 修饰的荧光素酶还具有比野生型萤光素酶更高的热稳定性。

公开(公告)号：US07057087B2

公开(公告)日：2006-06-06

申请号：US10206653

申请日：2002-07-26

申请人： Gopi Krishna Podila ,  Leland James Cseke ,  Banalata Sen ,  David F. Karnosky

发明人： Gopi Krishna Podila ,  Leland James Cseke ,  Banalata Sen ,  David F. Karnosky

IPC分类号： C12N15/29 ,  C12N15/82 ,  C12N15/87 ,  C12N5/04 ,  A01H5/00

CPC分类号： C12N15/8287 ,  C07H21/04 ,  C07K14/415 ,  C12N15/827

摘要： The present invention provides compositions and methods for producing a transgenic plant that exhibits altered characteristics resulting from over expression or under expression of a novel polypeptide PtM3 or its homolog PtM4. The altered characteristics resulting from over-expression include at least one of the ability to convert axillary meristem to floral meristem; to accelerate flowering i.e., early flowering; to increase fruit production; to increase nut production; to increase seed output; to increase branching; to increase flower production; to increase fruit yield; to increase flower yield and a combination thereof. The altered characteristics resulting from suppressed expression include at least one of complete sterility; partial sterility (sterility of only one sex of a bisexual plant); reduced pollen production; decreased flowering; increased biomass and combinations thereof. Furthermore, once the transgenic plant is sterile, additional exogenous sequences may be incorporated into the sterile plant genome, resulting in other desired plant characteristics. Related promoter, gene constructs, methods, antibodies and kits are also provided.

摘要翻译： 本发明提供了用于产生转基因植物的组合物和方法，其表现出由新型多肽PtM3或其同源物PtM4的过表达或低表达产生的改变的特征。 由过度表达引起的改变的特征包括将腋生分生组织转化为花分生组织的能力中的至少一种; 加速开花，即早开花; 增加水果生产; 增加坚果生产; 增加种子产量; 增加分支; 增加花卉生产; 提高果实产量; 以增加花的产量及其组合。 由抑制表达引起的改变的特征包括完全不育的至少一种; 部分不育（双性植物只有一性不育）; 降低花粉产量; 开花减少; 增加生物量及其组合。 此外，一旦转基因植物是无菌的，可以将另外的外源序列并入无菌植物基因组中，产生其它所需的植物特征。 还提供了相关的启动子，基因构建体，方法，抗体和试剂盒。

公开(公告)号：US20050250919A1

公开(公告)日：2005-11-10

申请号：US11181481

申请日：2005-07-14

申请人： Gerald Caneba ,  Yadunandan Dar

发明人： Gerald Caneba ,  Yadunandan Dar

IPC分类号： C08F2/38 ,  C08F293/00 ,  C08F297/02 ,  C08F4/06

CPC分类号： C08F297/026 ,  C08F293/005

摘要： The present invention is directed to a single stage free radical precipitation polymerization process for producing a copolymer involving admixing a solvent, a free-radical-forming agent, (meth)acrylic acid, and at least one monomer selected from the group consisting of styrene, vinyl acetate, methylmethacrylate, butyl acrylate, methyl acrylate, acrylonitrile, and isopropylacrylamide; initiating a free-radical precipitation polymerization to form a plurality of polymer radicals; precipitating a polymer from said polymer radicals; maintaining the admixture of reactants at a temperature above the lower critical solution temperature of said admixture; and controlling the temperature of said admixture to control the rate of propagation of the polymer. The process is useful for producing random copolymers of vinyl acetate or styrene with more than 4 percent and up to greater than 20 percent by weight of (meth)acrylic acid.

摘要翻译： 本发明涉及用于制备共聚物的单级自由基沉淀聚合方法，该方法包括混合溶剂，自由基形成剂，（甲基）丙烯酸和至少一种选自苯乙烯， 乙酸乙烯酯，甲基丙烯酸甲酯，丙烯酸丁酯，丙烯酸甲酯，丙烯腈和异丙基丙烯酰胺; 引发自由基沉淀聚合以形成多个聚合物基团; 从所述聚合物基团沉淀聚合物; 在高于所述混合物的临界溶解温度较低的温度下保持反应物的混合物; 并控制所述混合物的温度以控制聚合物的传播速率。 该方法可用于生产乙酸乙烯酯或苯乙烯的无规共聚物，其含量超过（甲基）丙烯酸重量的4％以上且高达20％以下。

公开(公告)号：US06952300B2

公开(公告)日：2005-10-04

申请号：US10469436

申请日：2002-02-27

申请人： Miguel Levy

发明人： Miguel Levy

IPC分类号： G02F1/095 ,  G02F1/09 ,  G02F1/00 ,  G02F1/295

CPC分类号： G02F1/0955 ,  G02F2202/32

摘要： A magneto-optical isolator (20) for an optical circuit. The isolator includes a substrate, and an optical channel (350) disposed next to the substrate. The optical channel and substrate are configured to transmit optical radiation within the optical channel. The isolator further includes a photonic-crystal rotator (24) formed with the substrate and the optical channel. The rotator has at least one defect (52) and magnetic (M) and non-magnetic (N) materials.

摘要翻译： 一种用于光电路的磁光隔离器（20）。 隔离器包括基板和邻近基板设置的光学通道（350）。 光通道和衬底被配置为在光通道内透射光辐射。 隔离器还包括由衬底和光通道形成的光子晶体旋转器（24）。 旋转体具有至少一个缺陷（52）和磁性（M）和非磁性（N）材料。

公开(公告)号：US20050166283A1

公开(公告)日：2005-07-28

申请号：US11057518

申请日：2005-02-14

申请人： Vincent Chiang ,  Laigeng Li

发明人： Vincent Chiang ,  Laigeng Li

IPC分类号： A01H5/00 ,  A01H7/00 ,  C12N5/10 ,  C12N9/04 ,  C12N15/09 ,  C12N15/29 ,  C12N15/82 ,  A01H1/00

CPC分类号： C12N9/0006 ,  C12N15/8246 ,  C12N15/8255

摘要： The present invention relates to a method of concurrently introducing multiple genes into plants and trees is provided. The method includes simultaneous transformation of plants with multiple genes from the phenylpropanoid pathways including 4CL, CAld5H, AldOMT, SAD and CAD genes and combinations thereof to produce various lines of transgenic plants displaying altered agronomic traits. The agronomic traits of the plants are regulated by the orientation of the specific genes and the selected gene combinations, which are incorporated into the plant genome.

公开(公告)号：US20050051755A1

公开(公告)日：2005-03-10

申请号：US10899544

申请日：2004-07-27

申请人： Russell Alger

发明人： Russell Alger

IPC分类号： C09K3/18 ,  E01C7/35 ,  E01C11/24

CPC分类号： E01C7/356 ,  C09K3/18 ,  C09K3/185 ,  E01C11/245

摘要： A method of inhibiting or preventing bonding between snow or ice and a substrate. The method may include applying an adhesive to a substrate, applying aggregate onto the adhesive and applying an anti-icing chemical thereon. Alternatively, the method may include grinding the aggregate, roughening the substrate and stimulating an aggregate/adhesive/anti-icing chemical composition.

摘要翻译： 一种抑制或防止雪或冰与基底之间的接合的方法。 该方法可以包括将粘合剂施加到基底上，将聚集体施加到粘合剂上并在其上施加防冰化学品。 或者，该方法可以包括研磨聚集体，使基底粗糙化并刺激聚集体/粘合剂/防冰化学组合物。

公开(公告)号：US20050050585A1

公开(公告)日：2005-03-03

申请号：US10939794

申请日：2004-09-13

申请人： Vincent Chiang ,  Laigeng Li

发明人： Vincent Chiang ,  Laigeng Li

IPC分类号： C12N9/04 ,  C12N15/29 ,  C12N15/82 ,  C12N9/02 ,  A01H1/00 ,  A01H7/00 ,  C07H21/04 ,  C12N5/04

CPC分类号： C12N9/0006 ,  C12N15/8246 ,  C12N15/8255

摘要： The present invention relates to a novel DNA sequence, which encodes a previously unidentified lignin biosynthetic pathway enzyme, sinapyl alcohol dehydrogenase (SAD) that regulates the biosynthesis of syringyl lignin in plants. Also provided are methods for incorporating this novel SAD gene sequence or substantially similar sequences into a plant genome for genetic engineering of syringyl-enriched lignin in plants.

摘要翻译： 本发明涉及编码先前未鉴定的木质素生物合成途径酶，调节植物中丁香木质素生物合成的萘普生脱氢酶（SAD）的新型DNA序列。 还提供了将该新型SAD基因序列或基本上相似的序列并入植物基因组中用于在植物中富含丁香醛的木质素进行遗传工程的方法。

公开(公告)号：US06855864B2

公开(公告)日：2005-02-15

申请号：US09947027

申请日：2001-09-05

申请人： Vincent Lee C. Chiang ,  Laigeng Li

发明人： Vincent Lee C. Chiang ,  Laigeng Li

IPC分类号： A01H5/00 ,  A01H7/00 ,  C12N5/10 ,  C12N9/04 ,  C12N15/09 ,  C12N15/29 ,  C12N15/82 ,  C12N5/04

CPC分类号： C12N9/0006 ,  C12N15/8246 ,  C12N15/8255

摘要： The present invention relates to a method of concurrently introducing multiple genes into plants and trees is provided. The method includes simultaneous transformation of plants with multiple genes from the phenylpropanoid pathways including 4CL, CAld5H, AldOMT, SAD and CAD genes and combinations thereof to produce various lines of transgenic plants displaying altered agronomic traits. The agronomic traits of the plants are regulated by the orientation of the specific genes and the selected gene combinations, which are incorporated into the plant genome.

摘要翻译： 本发明涉及同时将多种基因引入植物和树木的方法。 该方法包括同时从具有4CL，CAld5H，AldOMT，SAD和CAD基因的苯丙素途径的多基因的植物同时转化植物，并组合它们以产生显示改变的农艺性状的各种转基因植物系。 植物的农艺性状受特定基因和所选择的基因组合的取向调节，这些基因组合被并入植物基因组中。

公开(公告)号：US20040235497A1

公开(公告)日：2004-11-25

申请号：US10848749

申请日：2004-05-19

申请人： Board of Control of Michigan Technological University

发明人： Seyed A. Zekavat

IPC分类号： H04B001/02

CPC分类号： G01S5/12 ,  H04W64/00

摘要： A method of locating mobiles via a dynamic base station. The method includes transmitting a first wireless signal from the dynamic base station at a first time, and receiving the first wireless signal at the mobile. The method also includes transmitting a second wireless signal from the mobile in response to receiving the first wireless signal, and receiving the second wireless signal at the dynamic base station at a second time. The method also includes determining a time difference between the first time and the second time, determining an angle of arrival of the second wireless signal, and locating the mobile based on the angle of arrival and the time difference.

摘要翻译： 一种通过动态基站定位手机的方法。 该方法包括在第一时间从动态基站发送第一无线信号，以及在移动台处接收第一无线信号。 该方法还包括响应于接收到第一无线信号而从移动台发送第二无线信号，以及在第二时间在动态基站处接收第二无线信号。 该方法还包括确定第一时间和第二时间之间的时间差，确定第二无线信号的到达角度，以及基于到达角度和时间差定位移动台。