公开(公告)号：US20230053759A1

公开(公告)日：2023-02-23

申请号：US17811888

申请日：2022-07-12

Applicant: DIPHARMA FRANCIS S.R.L.

Inventor： Francesca Della Penna ,  Valeria Nori ,  Fabio Pesciaioli ,  Armando Carlone

IPC: C07C45/65 ,  C07C209/78

Abstract: The present disclosure provides a new procedure for preparing a key intermediate for active pharmaceutical ingredients useful in the treatment of diseases related to the central nervous system.

公开(公告)号：US10752654B2

公开(公告)日：2020-08-25

申请号：US16090853

申请日：2017-04-03

Applicant: DIPHARMA FRANCIS S.r.l.

Inventor： Gabriele Razzetti ,  Anna Iuliano ,  Luca Giannotti ,  Grazia Iannucci ,  Emanuele Attolino ,  Vittorio Lucchini ,  Renzo Graziosi

IPC: C07J9/00 ,  C07J21/00

Abstract: The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.

公开(公告)号：US20170101365A1

公开(公告)日：2017-04-13

申请号：US15314082

申请日：2015-05-26

Applicant: DIPHARMA FRANCIS S.R.L.

Inventor： Pietro ALLEGRINI ,  Gabriele RAZZETTI ,  Dario PASTORELLO

IPC: C07C247/04 ,  C07D498/04 ,  C07C59/265 ,  C07C209/82

CPC classification number: C07C247/04 ,  C07C59/265 ,  C07C209/82 ,  C07D498/04

Abstract: The present invention relates to azidoalkylamine salts of formula (I) with organic acids, a process for their preparation, and their use as intermediates in the preparation of active pharmaceutical ingredients or polymers, or as spacers useful in organis synthesis. NH2—(CH2)n-N3 (I)

公开(公告)号：US20170036991A1

公开(公告)日：2017-02-09

申请号：US15228122

申请日：2016-08-04

Applicant: DIPHARMA FRANCIS S.r.l.

Inventor： Massimo MAGNANI ,  Enrico BRUNOLDI ,  Gabriele RAZZETTI ,  Alessandro RESTELLI

IPC: C07C227/40 ,  C07C229/08 ,  C07C227/42

CPC classification number: C07C227/40 ,  C07C227/42 ,  C07C229/08

Abstract: The present invention relates to a new process for the isolation and purification of 6-aminocaproic acid, which is a known inhibitor of enzymes responsible for fibrinolysis and is used in the treatment of coagulopathies and severe post-operative bleedings.

Abstract translation: 本发明涉及用于分离和纯化6-氨基己酸的新方法，其是负责纤维蛋白溶解的酶的已知抑制剂，并且用于治疗凝血病和严重的术后出血。

公开(公告)号：US20160376253A1

公开(公告)日：2016-12-29

申请号：US15194773

申请日：2016-06-28

Applicant: DAPHARMA FRANCIS s.r.l.

Inventor： Emanuele Attolino ,  Davide Rossi ,  Gabriele Razzetti

IPC: C07D401/06

CPC classification number: C07D401/06

Abstract: The present invention relates to a process for the preparation of efinaconazole.

Abstract translation: 本发明涉及一种制备艾芬康唑的方法。

公开(公告)号：US20140275542A1

公开(公告)日：2014-09-18

申请号：US14205684

申请日：2014-03-12

Applicant: DIPHARMA FRANCIS S.r.l.

Inventor： Maurizio TADDEI ,  Luca GIANNOTTI ,  Emanuele ATTOLINO ,  Pietro ALLEGRINI

IPC: C07D405/12 ,  C07D209/08

CPC classification number: C07D405/12 ,  C07D209/08

Abstract: Process for the preparation of a piperazinyl derivative, and its intermediates, which has known activity as a serotonin reuptake inhibitor and is used in therapy for treating serious symptoms of depression in adults.

Abstract translation: 制备哌嗪衍生物及其中间体的方法，其已知活性为5-羟色胺再摄取抑制剂，并用于治疗成人抑郁症的严重症状。

公开(公告)号：US08455678B2

公开(公告)日：2013-06-04

申请号：US12972573

申请日：2010-12-20

Applicant: Marco Artico ,  Emanuele Attolino ,  Pietro Allegrini

Inventor： Marco Artico ,  Emanuele Attolino ,  Pietro Allegrini

IPC: C07C67/28

CPC classification number: C07C213/06 ,  C07C219/28

Abstract: Disclosed is a process for the preparation of (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) or a pharmaceutically acceptable salt thereof having a low content of impurities such as tolterodine and tolterodine isobutyrate.

Abstract translation: 公开了制备具有低含量杂质的（R）-2-（3-二异丙基氨基-1-苯基丙基）-4-（羟甲基）苯酚异丁酸酯（非索罗定）或其药学上可接受的盐的方法，例如托特罗定 和异丁酸托特罗定。

公开(公告)号：US20120165525A1

公开(公告)日：2012-06-28

申请号：US13325179

申请日：2011-12-14

Applicant: Pietro ALLEGRINI ,  Emanuele ATTOLINO ,  Marco ARTICO

Inventor： Pietro ALLEGRINI ,  Emanuele ATTOLINO ,  Marco ARTICO

IPC: C07D473/04

CPC classification number: C07D473/04

Abstract: The present invention relates to processes for the preparation of 8-(3R)-3-aminopiperidinyl)-7-butyn-2-yl-3 -methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione and novel intermediates useful in its synthesis.

Abstract translation: 本发明涉及制备8-（3R）-3-氨基哌啶基）-7-丁炔-2-基-3-甲基-1-（4-甲基 - 喹唑啉-2-基甲基）-3,7 - 二氢嘌呤-2,6-二酮及其合成中有用的新型中间体。

公开(公告)号：US20110269962A1

公开(公告)日：2011-11-03

申请号：US13092171

申请日：2011-04-22

Applicant: Maurizio TADDEI ,  Evita BALDUCCI ,  Emanuele ATTOLINO ,  Simone MANTEGAZZA ,  Gianmaria DELL'ANNA

Inventor： Maurizio TADDEI ,  Evita BALDUCCI ,  Emanuele ATTOLINO ,  Simone MANTEGAZZA ,  Gianmaria DELL'ANNA

IPC: C07D215/14 ,  C07F7/18

CPC classification number: C07D215/14

Abstract: Process for the preparation of β-ketoester synthetic intermediates useful in the preparation of statins, in particular Pitavastatin.

Abstract translation: 用于制备可用于制备他汀类药物的合成中间体的方法，特别是匹他伐他汀。

公开(公告)号：US20100297711A1

公开(公告)日：2010-11-25

申请号：US12785746

申请日：2010-05-24

Applicant: Gabriele RAZZETTI ,  Sergio Riva ,  Pietro Allegrini ,  Mario Michieletti ,  Emanuele Attolino

Inventor： Gabriele RAZZETTI ,  Sergio Riva ,  Pietro Allegrini ,  Mario Michieletti ,  Emanuele Attolino

IPC: C12P13/24 ,  C12P9/00

CPC classification number: C07F9/3264 ,  C07F9/306 ,  C07F9/572

Abstract: Process for the preparation of intermediates useful in the synthesis of [1[S(R)],2α,4β]-4-cyclohexyl-1-[[[(2-methyl-1-oxypropoxy)propoxy](4-phenylbutyl)phosphinyl]acetyl]-L-proline, and the synthesis thereof, in particular as sodium salt.

Abstract translation: 制备可用于合成[1 [S（R）]，2α，4α-环己基-1 - [[[（2-甲基-1-氧丙氧基）丙氧基]（4-苯基丁基） ）氧膦基]乙酰基] -L-脯氨酸及其合成，特别是钠盐。