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公开(公告)号：US20200339622A1
公开(公告)日：2020-10-29
申请号：US16929186
申请日：2020-07-15
发明人： Gabriele RAZZETTI , Anna IULIANO , Luca GIANNOTTI , Grazia IANNUCCI , Emanuele ATTOLINO , Vittorio LUCCHINI , Renzo GRAZIOSI
摘要： The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
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公开(公告)号：US09751828B2
公开(公告)日：2017-09-05
申请号：US14747038
申请日：2015-06-23
IPC分类号： C07C213/08 , C07C57/15 , C12P13/00 , C07C213/00 , C07C213/06 , C07C219/28 , C07C51/41 , C07C213/10 , C07C51/43
CPC分类号： C07C213/08 , C07C51/43 , C07C57/15 , C07C213/06 , C07C213/10 , C07C219/28 , C12P13/005
摘要： Substantially stable to degradation Fesoterodine fumarate, a process for its preparation and a process for the synthesis of specific degradation impurities of Fesoterodine fumarate are disclosed.
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公开(公告)号：US20140303402A1
公开(公告)日：2014-10-09
申请号：US14243058
申请日：2014-04-02
IPC分类号： C07C315/02 , C07C317/36 , C07C319/18
CPC分类号： C07C315/02 , C07C317/14 , C07C317/36 , C07C319/18 , C07C323/09 , C07C319/14 , C07C315/04 , C07C315/06
摘要： Process for the preparation of known sulfonamides having antibacterial activity applicable on industrial scale, which allows their production in high yields and purity, comprising in particular the step of nucleophile aromatic substitution and oxidation in suitable conditions.
摘要翻译： 制备具有适用于工业规模的抗菌活性的已知磺酰胺的方法，其允许其以高产率和纯度生产，特别包括在合适条件下亲核芳香取代和氧化的步骤。
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公开(公告)号：US20140243369A1
公开(公告)日：2014-08-28
申请号：US14097398
申请日：2013-12-05
IPC分类号： C07D211/46
CPC分类号： C07D211/46 , C07D211/40
摘要： Process for the preparation of animinosugar, and the intermediates thereof, having known activity as a glycosyltransferase inhibitor and used, for example, in the treatment of Gaucher's disease.
摘要翻译： 具有已知的作为糖基转移酶抑制剂的活性的用于制备异烟肼的方法及其中间体，并且用于例如治疗戈谢氏病。
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公开(公告)号：US20230053759A1
公开(公告)日：2023-02-23
申请号：US17811888
申请日：2022-07-12
IPC分类号： C07C45/65 , C07C209/78
摘要： The present disclosure provides a new procedure for preparing a key intermediate for active pharmaceutical ingredients useful in the treatment of diseases related to the central nervous system.
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公开(公告)号：US10752654B2
公开(公告)日：2020-08-25
申请号：US16090853
申请日：2017-04-03
发明人： Gabriele Razzetti , Anna Iuliano , Luca Giannotti , Grazia Iannucci , Emanuele Attolino , Vittorio Lucchini , Renzo Graziosi
摘要： The invention relates to a process for preparing a compound of formula (I) in particular obeticholic acid and intermediates suitable for its synthesis.
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公开(公告)号：US20170101365A1
公开(公告)日：2017-04-13
申请号：US15314082
申请日：2015-05-26
IPC分类号： C07C247/04 , C07D498/04 , C07C59/265 , C07C209/82
CPC分类号： C07C247/04 , C07C59/265 , C07C209/82 , C07D498/04
摘要： The present invention relates to azidoalkylamine salts of formula (I) with organic acids, a process for their preparation, and their use as intermediates in the preparation of active pharmaceutical ingredients or polymers, or as spacers useful in organis synthesis. NH2—(CH2)n-N3 (I)
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公开(公告)号：US20170036991A1
公开(公告)日：2017-02-09
申请号：US15228122
申请日：2016-08-04
IPC分类号： C07C227/40 , C07C229/08 , C07C227/42
CPC分类号： C07C227/40 , C07C227/42 , C07C229/08
摘要： The present invention relates to a new process for the isolation and purification of 6-aminocaproic acid, which is a known inhibitor of enzymes responsible for fibrinolysis and is used in the treatment of coagulopathies and severe post-operative bleedings.
摘要翻译： 本发明涉及用于分离和纯化6-氨基己酸的新方法，其是负责纤维蛋白溶解的酶的已知抑制剂，并且用于治疗凝血病和严重的术后出血。
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公开(公告)号：US20140275542A1
公开(公告)日：2014-09-18
申请号：US14205684
申请日：2014-03-12
IPC分类号： C07D405/12 , C07D209/08
CPC分类号： C07D405/12 , C07D209/08
摘要： Process for the preparation of a piperazinyl derivative, and its intermediates, which has known activity as a serotonin reuptake inhibitor and is used in therapy for treating serious symptoms of depression in adults.
摘要翻译： 制备哌嗪衍生物及其中间体的方法，其已知活性为5-羟色胺再摄取抑制剂，并用于治疗成人抑郁症的严重症状。
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公开(公告)号：US20210101926A1
公开(公告)日：2021-04-08
申请号：US17063460
申请日：2020-10-05
IPC分类号： C07J9/00
摘要： Processes for the synthesis and purification of glycoconjugate derivatives of cholic acid are provided herein.
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