公开(公告)号：US11949103B2

公开(公告)日：2024-04-02

申请号：US18091233

申请日：2022-12-29

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  Dongguk University Industry—Academic Cooperation Foundation

发明人： Kyung Yoon Chung ,  Kyung-Wan Nam ,  Jaeho Park ,  Daniel Adjah Anang

IPC分类号： H01M4/525 ,  H01M4/04 ,  H01M4/131 ,  H01M4/1391 ,  H01M4/36 ,  H01M4/66 ,  H01M10/058

CPC分类号： H01M4/525 ,  H01M4/0471 ,  H01M4/131 ,  H01M4/1391 ,  H01M4/364 ,  H01M4/667 ,  H01M10/058

摘要： The present disclosure relates to an anode electrode active material for a secondary battery containing nickel cobalt molybdenum oxide, an anode electrode for a secondary battery including the same, a secondary battery including the anode electrode for a secondary battery, and a method for manufacturing the same. The novel anode electrode material for a sodium secondary battery containing nickel cobalt molybdenum oxide according to the present disclosure allows intercalation/deintercalation reaction of sodium ion during charge/discharge and does not undergo significant volume change during the intercalation reaction because structure is maintained stably during repeated charge/discharge. As a result, electrode damage and electric short circuit are decreased and, thus, improved electrochemical characteristics can be achieved in long-life and high-rate capability.

公开(公告)号：US20230254605A1

公开(公告)日：2023-08-10

申请号：US18150619

申请日：2023-01-05

申请人： Samsung Electronics Co., Ltd.

发明人： Keunyeol PARK ,  Sooyoun Kim

IPC分类号： H04N25/772 ,  H04N25/709

CPC分类号： H04N25/772 ,  H04N25/709

摘要： Disclosed is an analog-to-digital converter including a comparison circuit and a counter circuit. The comparison circuit outputs a comparison result signal based on a pixel signal and a ramp signal and outputs a zero-crossing prediction signal, is the comparison circuit being configured to transition the zero-crossing prediction signal before a zero-crossing time point at which a voltage level of the pixel signal becomes identical to a voltage level of the ramp signal and during a time interval during which the voltage level of the ramp signal is reduced. The counter circuit outputs a low-order bit digital code based on the zero-crossing prediction signal and stops the output of the low-order bit digital code based on the comparison result signal.

公开(公告)号：US20230059930A1

公开(公告)日：2023-02-23

申请号：US17285430

申请日：2019-12-13

申请人： DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Jongpil KIM ,  Junsang YOO

IPC分类号： C12N15/67 ,  A61K35/30 ,  A61K35/32 ,  C12N13/00 ,  A61P19/00 ,  A61P25/00

摘要： Provided are a method of overexpressing a target gene and/or a method of reprogramming cells, the method including steps of (a) introducing a vector into cells, into which vector a promoter and a target gene are inserted; and (b) applying an electromagnetic wave to the cells obtained in the step (a), and a method of treating a disease using the method.
When the method of overexpressing a target gene using the electromagnetic wave-reactive promoter of the present disclosure is used, it is possible to artificially regulate expression levels of desired target genes in a simple manner in vivo and in vitro and to regulate expression of the target genes until a desired predetermined time.

公开(公告)号：US11184152B2

公开(公告)日：2021-11-23

申请号：US16673971

申请日：2019-11-05

申请人： DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  Industry-Academic Cooperation Foundation, Chosun University

发明人： Dae Woon Lim ,  Young Sik Kim ,  Ki Soon Yu

IPC分类号： H04L9/32 ,  H04L9/06 ,  H04L9/00 ,  H04L9/08 ,  H03M13/11 ,  H03M13/09 ,  H04L9/14

摘要： Disclosed is an electronic device for performing code-based encryption supporting integrity verification of a message and an operating method thereof. When a data transmission side encrypts a message through code-based encryption and transmits the encrypted message to a data reception apparatus, the data transmission side is allowed to use a hash value generated based on a part of the message as an error in code-based encryption to support the data reception apparatus to verify an integrity of a received message by using the hash value.

公开(公告)号：US11045498B2

公开(公告)日：2021-06-29

申请号：US16097698

申请日：2017-06-16

申请人： DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Gun Il Im ,  Jong Min Lee ,  Ji Yun Ko

IPC分类号： A61K35/28 ,  C07K14/47 ,  C12N15/85 ,  A61K48/00 ,  A61K35/00 ,  A61K38/00 ,  C12N15/90

摘要： The present invention relates to a non-viral minicircle vector expressing a SOX gene, a stem cell into which the vector is introduced, a pharmaceutical composition for preventing or treating a cartilage disease, including the stem cell, and a method for constructing the vector. The transformation of mesenchymal stem cells with MC/SOX-Trio or MC/SOX-Duo, which is a non-viral minicircle vector according to the present invention, can completely exclude the necessity of expensive growth factors that have been indispensably used in inducing the differentiation of mesenchymal stem cells into chondrocytes. Accordingly, the mesenchymal stem cells transformed therewith, when implanted in vivo, can differentiate into chondrocytes by themselves, and thus have an advantage capable of simplifying the existing complicated steps of culturing cells to induce differentiation and then transplanting the cells.
Further, unlike existing vector systems in which antibiotic-resistant genes and other bacteria-derived exogenous genes are simultaneously transferred to cells even after transformation, the vector of the present invention minimizes transfer of unnecessary genes into target cells by allowing two or three SOX genes necessary only for differentiation into chondrocytes to be regulated under one promoter, and thus can be utilized as a non-viral vector system in the most advantageous form for use in clinical application of stem cell-gene therapeutic agents.

公开(公告)号：US10258662B2

公开(公告)日：2019-04-16

申请号：US14894210

申请日：2014-04-29

申请人： DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION

发明人： Choongho Lee ,  Tae Hwe Heo ,  Kee Dong Yoon

IPC分类号： A61K36/87

摘要： Provided is a method for preventing or treating hepatitis C by administrating a composition including, as an active ingredient, a Vitidis Vinferae Radix extract or a fraction thereof and, more specifically, to a Vitidis Vinferae Radix extract which is extracted with water and alcohol or a mixed solvent thereof, or a fraction thereof, which have remarkably low hepatotoxicity and exhibit an excellent effect of selectively inhibiting genome replication of a hepatitis C virus, and thus can be useful for preventing or treating hepatitis C.

公开(公告)号：US10155753B2

公开(公告)日：2018-12-18

申请号：US15295293

申请日：2016-10-17

申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  Dongguk University Industry-Academic Cooperation Foundation

发明人： Youngjoo Byun ,  Chang Hoon Lee

IPC分类号： C07D209/12 ,  C07D209/14 ,  C07D409/10 ,  C07D413/04 ,  C07D413/14

摘要： Disclosed are 4-substituted-2-(5-substituted-1H-indol-2-yl)phenol derivatives for controlling the proliferation and migration of kinase-overexpressed cells. The phenol derivatives are represented by Formula 1: wherein X is selected from the group consisting of hydrogen, halogen, a cyano group, a trifluoromethyl (CF3) group, an amidine (C(═NH)NH2) group, and a 5-methyl-1,2,4-oxadiazole group, Y is selected from the group consisting of hydrogen, halogen, a phenyl group substituted with one or two substituents selected from the group consisting of halogen, methoxy, nitro, trifluoromethyl, and aminomethyl, CO—R′, COOR′, OH, O—R′, and NH—R′, each R′ is independently selected from the group consisting of C1-C18 alkyl, alkenyl, alkynyl, and —Z-alkyl (wherein Z is a heteroatom selected from the group consisting of O, S, and N or is —(CH2)m—), and m is an integer from 0 to 5. Also disclosed are methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives. The phenol derivatives and the pharmaceutical compositions can effectively inhibit the proliferation and migration of kinase-overexpressed cells and can be used for the prevention or treatment of various solid cancers and metastatic cancers.

公开(公告)号：US09789114B2

公开(公告)日：2017-10-17

申请号：US15067057

申请日：2016-03-10

申请人： DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

发明人： Kyeong Lee ,  Mi-Sun Won ,  Hwan-Mook Kim ,  Song-Kyu Park ,  Ki-Ho Lee ,  Chang-Woo Lee ,  Bo-Kyung Kim ,  Hyun-Seung Ban ,  Kyung-Sook Chung ,  Naik Ravi

IPC分类号： A61K31/495 ,  A61K31/5375 ,  C07D295/185 ,  C07D295/073 ,  C07D241/04 ,  C07C235/20 ,  C07C235/22 ,  C07C231/02 ,  C07D295/108 ,  C07D295/182 ,  C07D487/04 ,  A61K31/4985 ,  C07D279/12 ,  C07D295/104 ,  C07D307/46

CPC分类号： A61K31/5375 ,  A61K31/495 ,  A61K31/4985 ,  C07C231/02 ,  C07C235/20 ,  C07C235/22 ,  C07D241/04 ,  C07D279/12 ,  C07D295/073 ,  C07D295/104 ,  C07D295/108 ,  C07D295/182 ,  C07D295/185 ,  C07D307/46 ,  C07D487/04

摘要： The present invention relates to novel compounds as HIF-1α inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against HIF-1α, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer. Also, the compounds according to the present invention are useful in the treatment of diabetic retinopathy and rheumatoid arthritis, which are aggravated by HIF-1α-mediated VEGFA expression.

公开(公告)号：US20170174645A1

公开(公告)日：2017-06-22

申请号：US15449465

申请日：2017-03-03

申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Kyeong LEE ,  Sei-Ryang OH ,  Kyung Seop AHN ,  Ok-Kyoung KWON ,  Doo-Young KIM ,  Hyung Won RYU ,  Jung Hee KIM ,  Xuezhen XU

IPC分类号： C07D307/86 ,  A23L33/10

CPC分类号： C07D307/86 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/05 ,  A61K31/343 ,  C07D307/78 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81

摘要： The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.

公开(公告)号：US09596663B2

公开(公告)日：2017-03-14

申请号：US13575863

申请日：2011-01-27

申请人： Jong Soo Choi ,  Byoung Jo Choi ,  Seung Hoon Hwang ,  Young Bum Kim ,  Ho Yong Lim

发明人： Jong Soo Choi ,  Byoung Jo Choi ,  Seung Hoon Hwang ,  Young Bum Kim ,  Ho Yong Lim

IPC分类号： H04W4/00 ,  H04B7/00 ,  H04W52/42 ,  H04L25/02 ,  H04L27/00 ,  H04L27/18 ,  H04W52/32 ,  H04B7/26

CPC分类号： H04W52/42 ,  H04B7/2656 ,  H04L25/0204 ,  H04L27/0008 ,  H04L27/0012 ,  H04L27/183 ,  H04W52/325

摘要： A method and apparatus for transmitting a training sequence code of a transmitting apparatus with a plurality of transmitting antennas in a communication system are provided. A transmitting apparatus allocates a plurality of time slots for the plurality of transmitting antennas to be divided into at least one frame, and sends a training sequence code with reference power for any one of the transmitting antennas, and sends remaining training sequence codes for remainders of the transmitting antennas with transmission power from zero to the reference power, in any one of the time slots. A receiving apparatus receives a plurality of training sequence codes for a plurality of transmitting antennas through any one of the plurality of receiving antennas from a transmitting apparatus, and selects one of the training sequence codes having the greatest reception power to estimate a channel. This may improve a channel estimation performance in a communication system.

摘要翻译： 提供一种用于在通信系统中发送具有多个发送天线的发送装置的训练序列码的方法和装置。 发送装置为将被分割为至少一个帧的多个发送天线分配多个时隙，并向发送天线中的任何一个发送具有参考功率的训练序列码，并发送剩余的训练序列码， 发射天线的发射功率从零到参考功率，在任一时隙中。 接收装置从发送装置通过多个接收天线中的任一个接收多个发送天线的多个训练序列码，并选择具有最大接收功率的训练序列码之一来估计信道。 这可以改善通信系统中的信道估计性能。