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公开(公告)号：US4784118A
公开(公告)日：1988-11-15
申请号：US43335
申请日：1987-04-28
CPC分类号： A61B1/002 , A61B1/00165
摘要： An apparatus for viewing a region within a body cavity or the like. The apparatus includes an elongate light pipe having a distal end and a proximal end, which light pipe illuminates the region to be viewed adjacent the distal end of the pipe. An objective lens system is carried at that distal end which in a preferred embodiment forms a focused real image of the illuminated region. This image is transmitted to the viewer through a series of relay lenses and, at the proximal end of the apparatus, through a viewing lens system. The light pipe and the lenses are composed of a polymeric material such as styrene, polycarbonate, acrylic, or the like, and are preferably aspheric lenses.
摘要翻译： 一种用于观察体腔等内的区域的装置。 该设备包括具有远端和近端的细长光管，该光管照亮邻近管道远端的区域。 在该远端承载物镜系统，其在优选实施例中形成照明区域的聚焦实像。 该图像通过一系列中继透镜并在设备的近端通过观察透镜系统传输给观看者。 光管和透镜由诸如苯乙烯，聚碳酸酯，丙烯酸等的聚合材料组成，并且优选为非球面透镜。
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公开(公告)号：US06986994B2
公开(公告)日：2006-01-17
申请号：US10036418
申请日：2002-01-07
IPC分类号： G01N33/53
CPC分类号： C07K14/474 , C07K14/4733 , G01N33/6854 , Y10T436/105831 , Y10T436/11
摘要： An antibody is provided which specifically recognizes and binds to INGAP protein. The antibody is used in competitive binding assays for quantitation of INGAP in biological samples. The assay can be performed on a solid support or in a suspension.
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公开(公告)号：US20030166031A1
公开(公告)日：2003-09-04
申请号：US10376046
申请日：2003-02-27
IPC分类号： G01N033/53 , G01N033/537 , G01N033/543
CPC分类号： G01N33/6854 , G01N2333/4733 , G01N2333/474 , G01N2410/00
摘要： A solid phase assay is used for detecting antibodies to INGAP104-118 peptide, a 15-amino acid peptide that is the biologically active portion of islet neogenesis associated protein (INGAP). The isotype of the antibodies to INGAP104-118 peptide can be determined. A kit can also be used in the detection of anti-INGAP104-118 antibodies. Endogenous autoantibodies or antibody production during therapeutic treatment of a mammal with INGAP104-118 can be monitored.
摘要翻译： 使用固相测定法检测INGAP104-118肽的抗体，该肽是作为胰岛新生相关蛋白（INGAP）的生物活性部分的15个氨基酸的肽。 可测定INGAP104-118肽抗体的同种型。 一种试剂盒也可用于检测抗INGAP104-118抗体。 可以监测在具有INGAP104-118的哺乳动物治疗期间的内源性自身抗体或抗体产生。
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4.发明授权
公开(公告)号：US4920974A
公开(公告)日：1990-05-01
申请号：US181217
申请日：1988-04-13
CPC分类号： A61B10/0291 , A61B2017/00438
摘要： A method is provided for obtaining cervical cell culture specimens. The method makes use of a test device which may be used in conjunction with the manual cervical examination prior to delivery. The device includes an elastically resilient sheath adapted to grip a finger and a sterile pad of absorbent material on one end adapted to collect and retain the cell culture specimen. A kit is provided as well, the kit including a support member for maintaining the device in an unrolled, elongated, unrolled configuration and is designed so as to maintain sterile conditions and minimize contamination during storage and transport.
摘要翻译： 提供了一种获得宫颈细胞培养标本的方法。 该方法使用可在交付前与手动子宫颈检查结合使用的测试装置。 该装置包括弹性弹性鞘，其适于在适于收集和保持细胞培养样本的一端上夹持手指和吸收材料的无菌垫。 还提供了试剂盒，该试剂盒包括用于将装置保持在展开的，细长的，展开的结构中的支撑构件，并被设计成保持无菌条件并使储存和运输期间的污染最小化。
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公开(公告)号：US4654030A
公开(公告)日：1987-03-31
申请号：US832742
申请日：1986-02-24
CPC分类号： A61B17/3496 , A61B17/3474 , A61B2090/08021
摘要： A trocar assembly consisting of a trocar tube subassembly and a separable, interfitting trocar subassembly is described. The trocar tube assembly includes a hollow body having a first front opening in which a trocar tube is mounted, a second rear opening for receiving the trocar subassembly, and a manually pivotable flap valve mechanism mounted within the body. The trocar subassembly includes a head having a central bore in which are mounted the (1) rear ends of an elongated obturator having a pyramidal-shaped piercing head with a triangular-shaped base, and a concentric tubular shield having a triangular shaped front opening for the piercing head that is formed by bevels in its leading edge that have approximately the same slope as the surfaces that define the three sides of the piercing head, and (2) a coil spring backing the shield for biasing the shield between retracted and extended positions. When the two subassemblies are fit together, the obturator and concentric shield extend through the hollow body with the front wall of the head fitting within a recess in the rear wall of the hollow body such that the trocar assembly cannot be rotated without disengaging the two subassemblies. The shield has a slot in its outer wall that is engaged by the flap valve to lock the shield in its extended position. The shield may be unlocked by pivoting the flap valve out of the slot, sliding the trocar assembly rearwardly so that the front wall of the head is clear of the recess in the rear wall of the hollow body, rotating the trocar subassembly to a position in which the flap valve and slot are not aligned and sliding the front wall of the trocar assembly back into the recess in the rear wall of the hollow body.
摘要翻译： 描述了一种套管针组件，其由套管针管子组件和可分离的配合套管针组件组成。 套管针管组件包括具有第一前开口的套管针组件，其中安装有套管针管，用于容纳套管针组件的第二后开口，以及安装在主体内的可手动枢转的瓣阀机构。 套管针组件包括具有中心孔的头部，其中安装有（1）细长闭塞器的后端，其具有三角形基部的金字塔状刺穿头部，以及具有三角形前开口的同心管状护罩， 穿刺头由其前缘中的斜面形成，其具有与限定穿刺头的三个侧面的表面大致相同的倾斜度，以及（2）螺旋弹簧，用于将护罩偏压在缩回位置和伸出位置之间 。 当两个子组件装配在一起时，闭塞器和同心屏蔽件延伸穿过中空本体，头部的前壁装配在中空本体的后壁中的凹部内，使得套管针组件不能在不分离两个子组件的情况下旋转 。 屏蔽件在其外壁上具有狭槽，其通过瓣阀接合以将屏蔽件锁定在其延伸位置。 可以通过将瓣阀枢转离开槽来解除屏蔽，使套管针组件向后滑动，使得头部的前壁远离中空体的后壁中的凹部，将套管针组件旋转到 其中瓣阀和狭槽未对准并且将套管针组件的前壁滑回到中空体的后壁中的凹部中。
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公开(公告)号：US4601710A
公开(公告)日：1986-07-22
申请号：US638048
申请日：1984-08-06
申请人： Frederic H. Moll
发明人： Frederic H. Moll
CPC分类号： A61B17/3496 , A61B17/3474 , A61B2017/00473 , A61B2017/346 , A61B2090/08021
摘要： A trocar assembly (70) formed from a trocar tube subassembly (74) and a separable, interfitting trocar subassembly (72). The trocar tube assembly includes a head (112) having a bore (120) into which a trocar tube (116) is fitted and a manually operated slide valve assembly (118) mounted transversely of the bore in the head. The valve has a bore (134) through it that may be aligned with the bore in the head by movement of the valve. The trocar subassembly includes a head (76) that has a bore (92) extending partly through it in which a trocar obturator (82) and a concentric tubular shield (86) are mounted such that the shield is capable of limited axial movement relative to the obturator between a normal, extended position in which the shield effectively covers the piercing tip (84) of the obturator and a retracted position in which the tip is exposed. The obturator and shield are inserted through the bore in the trocar tube subassembly head, the slide valve bore and the trocar tube. The bore in the slide valve has a radial tooth (136) in it that engages a slot (138) in the shield to reversibly lock the shield in its extended position when the slide valve is in its normal position. The valve is depressed manually to disengage the tooth to allow axial movement of the shield or separation of the trocar subassembly from the trocar tube subassembly.
摘要翻译： 由套针管子组件（74）和可分离的相互配合的套管针组件（72）形成的套管针组件（70）。 套管针管组件包括具有孔（120）的头部（112），套管针（116）装配到所述孔中，以及手动操作的滑阀组件（118），横向安装在头部中的孔中。 阀具有穿过其的孔（134），其可以通过阀的移动与头部中的孔对准。 所述套管针组件包括头部（76），所述头部（76）具有部分延伸穿过所述孔（92），所述孔（92）安装在所述孔中，套管针闭塞器（82）和同心管状护罩（86）安装成使得所述护罩能够相对于 在其中屏蔽件有效地覆盖封闭器的刺穿尖端（84）的正常延伸位置和尖端暴露在其中的缩回位置之间的闭塞器。 闭塞器和护罩插入穿过套管针组件头部的孔中，滑阀孔和套管针管。 滑阀中的孔具有在其中的径向齿（136），其接合屏蔽件中的狭槽（138），以在滑阀处于其正常位置时将屏蔽件可逆地锁定在其延伸位置。 阀被手动地压下以使齿脱离以允许护罩的轴向运动或套管针子组件与套管针组件的分离。
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7.发明申请公开(公告)号：US20120058078A1
公开(公告)日：2012-03-08
申请号：US13195596
申请日：2011-08-01
IPC分类号： A61K38/20 , G01N27/447 , G01N33/559 , C12Q1/34 , A61P43/00
CPC分类号： C07K14/474 , C07K14/4733 , G01N2333/4733 , G01N2333/474
摘要： A reporter construct contains mammalian INGAP 5′-regulatory region or a fragment thereof, a minimal promoter element from mammalian INGAP or a heterologous promoter, and a reporter gene. The reporter construct can be used to screen for agents which alone or in combination up-regulate or down-regulate reporter gene expression. Alternatively, the reporter construct can be used to screen for agents that bind to the hamster INGAP 5′-regulatory region or a fragment thereof.
摘要翻译： 报道构建体含有哺乳动物INGAP5调控区或其片段，来自哺乳动物INGAP或异源启动子的最小启动子元件和报告基因。 报道构建体可用于筛选单独或组合上调或下调报告基因表达的试剂。 或者，报道构建体可用于筛选结合仓鼠INGAP 5'-调节区或其片段的试剂。
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8.发明申请公开(公告)号：US20090156458A1
公开(公告)日：2009-06-18
申请号：US12062740
申请日：2008-04-04
CPC分类号： C07K14/474 , C07K14/4733 , G01N2333/4733 , G01N2333/474
摘要： A reporter construct contains mammalian INGAP 5′-regulatory region or a fragment thereof, a minimal promoter element from mammalian INGAP or a heterologous promoter, and a reporter gene. The reporter construct can be used to screen for agents which alone or in combination up-regulate or down-regulate reporter gene expression. Alternatively, the reporter construct can be used to screen for agents that bind to the hamster INGAP 5′-regulatory region or a fragment thereof.
摘要翻译： 报道构建体含有哺乳动物INGAP5调控区或其片段，来自哺乳动物INGAP或异源启动子的最小启动子元件和报告基因。 报道构建体可用于筛选单独或组合上调或下调报告基因表达的试剂。 或者，报道构建体可用于筛选结合仓鼠INGAP 5'-调节区或其片段的试剂。
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9.发明授权Regulatory sequences for modulation of INGAP expression and reporter constructs 失效用于调节INGAP表达和报道构建体的调控序列公开(公告)号：US07355024B2
公开(公告)日：2008-04-08
申请号：US10339767
申请日：2003-01-09
IPC分类号： C07H21/04
CPC分类号： C07K14/474 , C07K14/4733 , G01N2333/4733 , G01N2333/474
摘要： A an isolated mammalian INGAP 5″-regulatory region comprising at least about nucleotides 1-3137 of SEQ ID NO: 2 (SEQ ID NO: 23).
摘要翻译： 分离的哺乳动物INGAP 5“调节区，其包含至少约SEQ ID NO：2的核苷酸1-3137（SEQ ID NO：23）。
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公开(公告)号：US4931042A
公开(公告)日：1990-06-05
申请号：US113013
申请日：1987-10-26
申请人： William A. Holmes , Peter F. Costa
发明人： William A. Holmes , Peter F. Costa
CPC分类号： A61B17/3496 , A61B2090/08021
摘要： A trocar assembly comprising an elongate trocar obturator having a piercing tip at its front end, an elongate trocar tube in which the obturator is housed, and a tubular protective shield mounted concentrically around the obturator between a normally extended position in which the obturator tip is covered and a retracted position in which the obturator tip is exposed. Further included is a spring acting on the protective shield, whereby the shield is forced to the retracted position to expose the piercing tip when the trocar is being inserted through the wall of a body cavity and is biased by the spring to the extended position to shield the piercing tip once the trocar has pierced the wall. A protrusion extends radially from the shield. A leaf spring element has one end anchored relative to the obturator and a second end biased to contact the protrusion in a manner preventing movement of the shield from the extended position toward the retracted position when the element is in contact with the protrusion. A trigger, coupled to the leaf spring member is shiftable between a lock position and a release position. When the trigger is in the lock position, the shield can not be moved from the extended position. When it is in the release position, the shield can travel to the retracted position. When it moves to the retracted position, it disengages the trigger so that when the shield returns to the extended position, it locks in place, even through the trigger is in the release position.
摘要翻译： 一种套管针组件，其包括在其前端具有穿刺尖端的细长套管针闭塞器，其中容纳所述闭孔器的细长套管针管，以及围绕所述闭孔器同心地安装在所述闭塞器尖端被覆盖的正常延伸位置的管状保护罩 以及收缩位置，其中闭嘴尖露出。 进一步包括作用在保护屏蔽上的弹簧，由此当套管针被插入穿过体腔的壁时，屏蔽件被迫到缩回位置以暴露穿刺尖端，并且被弹簧偏压到延伸位置以屏蔽 一旦套管针刺穿了墙壁，穿刺尖端。 突起从屏蔽件径向延伸。 板簧元件具有相对于闭孔器锚定的一端，以及当元件与突起接触时，被阻止以防止屏蔽件从延伸位置朝向缩回位置运动的方式接触突起的第二端。 联接到板簧构件的触发器可以在锁定位置和释放位置之间移动。 当触发器处于锁定位置时，屏蔽不能从伸出位置移动。 当其处于释放位置时，屏蔽件可以行进到缩回位置。 当它移动到缩回位置时，它使触发器脱离，使得当屏蔽件返回到延伸位置时，其锁定就位，即使通过触发器处于释放位置。
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