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    Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like
    2.
    发明授权
    Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like 失效
    用于在治疗心脏病况等中烧蚀组织以形成复杂病变图案的复合结构和方法

    公开(公告)号：US07115122B1

    公开(公告)日：2006-10-03

    申请号：US09505354

    申请日：2000-02-16

    申请人： David K. Swanson ,  Sidney D. Fleischman ,  Thomas F. Kordis ,  David L. McGee

    发明人： David K. Swanson ,  Sidney D. Fleischman ,  Thomas F. Kordis ,  David L. McGee

    IPC分类号： A61B18/18 ,  A61B19/00

    CPC分类号： A61B18/1492 ,  A61B2017/003 ,  A61B2018/00083 ,  A61B2018/00196 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/1437 ,  A61B2018/1467 ,  A61B2018/1497

    摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.

    摘要翻译： 心脏中消融组织以治疗心房颤动的方法将所选择的心房引入能量发射元件。 该方法将该元件暴露于心房壁的一个区域，并向该元件施加消融能量以热破坏组织。 该方法形成包括细长的直线损伤和细长的曲线损伤的褶皱病变图案。 病变图案沿着激活心房心肌的路径引导心房心肌内的电脉冲，同时中断再入电路，如果不中断，将引起原纤维化。 该方法模拟外科迷宫手术，但适用于不需要开放心脏手术技术的基于导管的手术。 用于执行该方法的复合结构使用在平面图中显示用于组织的期望损伤图案的模板来形成。 间隔开的元件阵列放置在模板上。 在模板的指导下，在元件上形成能量发射和非能量发射区。 通过覆盖元件，形成复合结构，其可以引入体内以使用基于导管的血管通路技术来烧蚀组织。

    Tissue heating and ablation systems and methods which predict maximum tissue temperature
    3.
    发明申请
    Tissue heating and ablation systems and methods which predict maximum tissue temperature 失效
    组织加热和消融系统和预测最大组织温度的方法

    公开(公告)号：US20030055419A1

    公开(公告)日：2003-03-20

    申请号：US09962662

    申请日：2001-09-24

    申请人： EP Technologies, Inc.

    发明人： Dorin Panescu ,  Sidney D. Fleischman ,  David K. Swanson

    IPC分类号： A61B018/18

    CPC分类号： A61B18/1206 ,  A61B18/1402 ,  A61B18/1492 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00791 ,  A61B2018/00803 ,  A61N1/403

    摘要： Systems and methods heat or ablate body tissue by positioning an electrode to transmit heat or ablation energy to a tissue region. The systems and methods measure a first temperature using a temperature sensing element associated with the electrode. The systems and methods also measure a second temperature using a temperature sensing element associated with the electrode. The systems and methods process at least one of the first and second temperatures to derive a prediction of maximum temperature of the tissue region. The systems and methods generate an output that controls the transmission of the heating or ablation energy based, at least in part, upon the maximum tissue temperature prediction.

    摘要翻译： 系统和方法通过将电极定位以将热量或消融能量传递到组织区域来加热或消融身体组织。 系统和方法使用与电极相关联的温度感测元件来测量第一温度。 系统和方法还使用与电极相关联的温度感测元件测量第二温度。 系统和方法处理第一和第二温度中的至少一个以导出组织区域的最大温度的预测。 系统和方法至少部分地基于最大组织温度预测产生控制加热或消融能量传递的输出。

    Systems and methods for seeking sub-surface temperature conditions during tissue ablation
    7.
    发明授权
    Systems and methods for seeking sub-surface temperature conditions during tissue ablation 失效
    在组织消融期间寻求次表面温度条件的系统和方法

    公开(公告)号：US6030379A

    公开(公告)日：2000-02-29

    申请号：US935281

    申请日：1997-09-22

    申请人： Dorin Panescu ,  Thomas M. Bourne

    发明人： Dorin Panescu ,  Thomas M. Bourne

    IPC分类号： A61B17/00 ,  A61B18/00 ,  A61B18/12 ,  A61B18/14 ,  A61N1/40

    CPC分类号： A61B18/1492 ,  A61N1/403 ,  A61B18/1206 ,  A61B2017/00084 ,  A61B2017/00243 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/0069 ,  A61B2018/126 ,  A61B2018/1861

    摘要： Systems and methods for ablating body tissue use an ablation element for contacting tissue to form a tissue interface. The ablation element is adapted to be connected to a source of ablation energy to conduct ablation energy for transmission by the ablation element into tissue at the tissue interface. The systems and methods include a tissue temperature sensing element held in a carrier in thermal conductive contact with tissue beneath the tissue interface. A mechanism attached to the carrier selectively advances the carrier relative to the ablation element to different depths beneath the tissue interface. A controller is coupled to the mechanism and to the tissue temperature sensing element to control advancement of the carrier beneath the tissue interface based, at least in part, upon tissue temperatures sensed by the sensing element beneath the tissue interface. Preferably, the controller controls the mechanism to locate the sensing element at the depth where the hottest sensed tissue temperature exists.

    摘要翻译： 用于消融身体组织的系统和方法使用消融元件来接触组织以形成组织界面。 消融元件适于连接到消融能量源，以传导消融能量，以将消融元件传导到组织界面处的组织中。 该系统和方法包括保持在载体中的组织温度感测元件，与组织界面下方的组织进行导热接触。 连接到载体的机构选择性地将载体相对于消融元件前进到组织界面下方的不同深度。 至少部分地，控制器耦合到机构和组织温度感测元件，以至少部分地基于由组织界面下方的感测元件感测的组织温度来控制组织界面下方的载体的前进。 优选地，控制器控制将感测元件定位在存在最热感测的组织温度的深度处的机构。

    Tissue heating and ablation systems and methods using self-heated electrodes
    8.
    发明授权
    Tissue heating and ablation systems and methods using self-heated electrodes 失效
    组织加热和消融系统和使用自热电极的方法

    公开(公告)号：US6022346A

    公开(公告)日：2000-02-08

    申请号：US480138

    申请日：1995-06-07

    申请人： Dorin Panescu ,  Sidney D. Fleischman ,  David K. Swanson

    发明人： Dorin Panescu ,  Sidney D. Fleischman ,  David K. Swanson

    IPC分类号： A61B18/12 ,  A61B18/14 ,  A61N1/40 ,  A61B17/39

    CPC分类号： A61B18/1206 ,  A61B18/1492 ,  A61N1/403 ,  A61B18/1402 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00791 ,  A61B2018/00803

    摘要： Systems and methods using an electrode able to transmit heating or ablation energy into tissue include first and second sensing elements associated with the electrode for measuring first and second temperatures. The electrode also includes a heating element in thermal conductive contact with the electrode for heating the electrode. The systems and methods sequentially activate the heating element and sense temperatures without transmitting tissue heating or ablation energy, and then transmit heating or ablation energy and sense temperatures without activating the heating element, to derive from the sensed temperatures a prediction of maximum tissue temperature.

    摘要翻译： 使用能够将加热或消融能量传递到组织中的电极的系统和方法包括与用于测量第一和第二温度的电极相关联的第一和第二感测元件。 电极还包括与用于加热电极的电极导热接触的加热元件。 系统和方法顺序地激活加热元件并且感测温度而不传递组织加热或消融能量，然后传递加热或消融能量并感测温度而不激活加热元件，从感测的温度导出最大组织温度的预测。

    Systems and methods employing structures having asymmetric mechanical properties to support diagnostic or therapeutic elements in contact with tissue in interior body regions
    9.
    发明授权
    Systems and methods employing structures having asymmetric mechanical properties to support diagnostic or therapeutic elements in contact with tissue in interior body regions 失效
    使用具有不对称机械性能的结构以支持与内部身体区域中的组织接触的诊断或治疗元件的系统和方法

    公开(公告)号：US6014590A

    公开(公告)日：2000-01-11

    申请号：US742564

    申请日：1996-10-28

    申请人： James G. Whayne ,  Sidney D. Fleischman ,  Dorin Panescu ,  Thomas F. Kordis ,  David K. Swanson

    发明人： James G. Whayne ,  Sidney D. Fleischman ,  Dorin Panescu ,  Thomas F. Kordis ,  David K. Swanson

    IPC分类号： A61B17/39

    摘要： Structures having asymmetric mechanical properties provide enhanced ability to support therapeutic or diagnostic elements in contact with tissue in an interior body region. The support structure includes a first region, which exhibits a first mechanical property affecting tissue contact, and a second region spaced from the first region about the axis, which exhibits a second mechanical property, different than the first mechanical property, affecting tissue contact. In a preferred embodiment, the first and second mechanical properties correlate with stiffness of the respective first and second regions, with the first region being more flexible (i.e., less stiff) than the second region. The first region, due to its greater flexibility, is more conformal to tissue than the second region. The less flexible (i.e., more stiff) second region imparts greater force against the tissue to urge the more flexible first region toward intimate tissue contact. In a preferred embodiment, the more flexible first region carries at least one therapeutic or diagnostic element.

    摘要翻译： 具有不对称机械特性的结构提供增强的能力，以支持与内部身体区域中的组织接触的治疗或诊断元件。 支撑结构包括表现出影响组织接触的第一机械特性的第一区域以及围绕轴线与第一区域隔开的第二区域，该第二区域具有影响组织接触的第二机械特性，该第二机械特性不同于第一机械特性。 在优选实施例中，第一和第二机械特性与相应的第一和第二区域的刚度相关，其中第一区域比第二区域更加柔性（即，较不硬）。 第一个区域由于其更大的灵活性，比第二个区域更适合组织。 较不柔性（即更硬）的第二区域赋予组织更大的力以促使更柔性的第一区域朝向紧密的组织接触。 在优选实施方案中，更灵活的第一区域携带至少一种治疗或诊断元件。

    Catheter and piston-type actuation device for use with same
    10.
    发明授权
    Catheter and piston-type actuation device for use with same 失效
    导管和活塞式致动装置，与其一起使用

    公开(公告)号：US6013052A

    公开(公告)日：2000-01-11

    申请号：US923216

    申请日：1997-09-04

    申请人： Bernie Durman ,  Chris Kunis ,  Robert Woodard ,  Fiona Sander

    发明人： Bernie Durman ,  Chris Kunis ,  Robert Woodard ,  Fiona Sander

    IPC分类号： A61B18/14 ,  A61M25/01 ,  A61M37/00

    CPC分类号： A61M25/0144 ,  A61B18/1492 ,  A61M25/0136 ,  A61M25/0147 ,  A61B2018/00916

    摘要： A catheter handle including a handle body defining a longitudinally extending handle aperture, a connector adapted to connect a steering wire to the handle body, a piston located at least partially within the handle aperture and slidable relative to the handle aperture, the piston being adapted to be operably connected to a catheter body, and a biasing element, operably connected to the piston, to bias the piston in the distal direction. As an alternative to the biasing element, or in addition, the catheter handle may also include a steering wire anchor associated with the handle body and including a movable portion operably connected to the proximal portion of the steering wire.

    摘要翻译： 导管手柄，其包括限定纵向延伸的手柄孔的手柄主体，适于将操纵线连接到手柄主体的连接器，至少部分地位于手柄孔内并可相对于手柄孔滑动的活塞，活塞适于 可操作地连接到导管主体，以及可操作地连接到活塞的偏压元件，以在远端方向上偏压活塞。 作为偏置元件的替代，或者另外，导管手柄还可以包括与手柄主体相关联的操纵线锚，并且包括可操作地连接到操纵线的近侧部分的可移动部分。