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    METHOD FOR TREATMENT OF AT RISK PATIENTS
    5.
    发明申请
    METHOD FOR TREATMENT OF AT RISK PATIENTS 有权

    公开(公告)号：US20220241232A1

    公开(公告)日：2022-08-04

    申请号：US17617011

    申请日：2020-06-08

    申请人： GENFIT

    发明人： JOHN BROZEK ,  NOÉMIE DAM ,  YACINE HAJJI ,  RÉMY HANF

    IPC分类号： A61K31/201 ,  A61K45/06

    摘要： The invention provides an anti-fibrotic or anti-nonalcoholic steatohepatitis (NASH) drug for use in a method for reducing the risk for a subject to develop liver fibrosis or NASH, wherein the drug is administered to a subject classified as at risk to develop liver fibrosis or NASH. The invention further provides an anti-fibrotic or anti-NASH substance for use in a method for the treatment of liver fibrosis or NASH, wherein the drug is administered to a subject having type 2 diabetes.

    1,3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES THEREOF
    8.
    发明申请
    1,3-DIPHENYLPROPANE DERIVATIVES, PREPARATIONS AND USES THEREOF 有权
    1,3-二苯基丙酸衍生物，其制备及其用途

    公开(公告)号：US20140350112A1

    公开(公告)日：2014-11-27

    申请号：US14368823

    申请日：2012-12-28

    申请人： GENFIT

    发明人： Mathieu Dubernet ,  Jean-Francois Delhomel ,  Karine Bertrand

    IPC分类号： C07C59/72 ,  C07C323/62

    CPC分类号： C07C59/72 ,  C07C323/19 ,  C07C323/62 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/16

    摘要： The present invention relates to novel 1,3-diphenylpropane derivatives, pharmaceutical compositions comprising the same and therapeutic uses thereof, in particular in the fields of human and animal health. The compounds according to the present invention have intrinsic PPAR agonist properties. They are therefore of particular interest in the treatment of metabolic and/or inflammatory diseases and particularly peripheral and central diseases associated with the metabolic syndrome, such as diverse forms of steatohepatitis, type 2 diabetes, diverse neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and multiple sclerosis.

    摘要翻译： 本发明涉及新的1,3-二苯基丙烷衍生物，包含其的药物组合物及其治疗用途，特别是在人和动物健康领域。 根据本发明的化合物具有固有的PPAR激动剂特性。 因此，它们特别关心于代谢和/或炎性疾病，特别是与代谢综合征相关的外周和中枢疾病的治疗，例如多种形式的脂肪性肝炎，2型糖尿病，多种神经变性疾病如阿尔茨海默氏病，帕金森病 和多发性硬化症。

    USE OF 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES FOR TREATING LIVER DISORDERS
    9.
    发明申请
    USE OF 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES FOR TREATING LIVER DISORDERS 有权
    用于治疗肝脏疾病的1,3-二苯基丙-2-烯-1-酮衍生物的应用

    公开(公告)号：US20140309165A1

    公开(公告)日：2014-10-16

    申请号：US14288482

    申请日：2014-05-28

    申请人： GENFIT

    发明人： Raphael DARTEIL ,  Rémy Hanf ,  Dean Hum ,  Ingrid Dufour

    IPC分类号： A61K31/192 ,  A61K45/06

    CPC分类号： A61K31/192 ,  A61K31/155 ,  A61K31/216 ,  A61K38/28 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as amino-transferases. The 1,3-diphenylprop-2-en-1-one derivatives of General Formula (I) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease.

    摘要翻译： 本发明提供了1,3-二苯基丙-2-烯-1-酮衍生物和包含其的医药组合物，其用于治疗肝脏疾病，特别是那些需要降低生物化学标志物如氨基转移酶的血浆水平的那些。 通式（I）的1,3-二苯基丙-2-烯-1-酮衍生物具有肝保护性质，可用于治疗涉及肝细胞的病理破坏，炎症，变性和/或增殖的肝脏疾病的方法 ，如肝纤维化或脂肪肝病。

    Preparation of chalcone derivatives
    10.
    发明授权
    Preparation of chalcone derivatives 有权
    查耳酮衍生物的制备

    公开(公告)号：US08765992B2

    公开(公告)日：2014-07-01

    申请号：US13698832

    申请日：2011-05-16

    申请人： Karine Bertrand ,  Alice Roudot ,  Patrice Rool

    发明人： Karine Bertrand ,  Alice Roudot ,  Patrice Rool

    IPC分类号： C07C321/00 ,  C07C323/00 ,  C07C381/00

    CPC分类号： C07C319/12 ,  C07C45/45 ,  C07C67/08 ,  C07C67/31 ,  C07C319/20 ,  C07C69/738 ,  C07C323/22

    摘要： The invention relates to methods for producing chalcone (1,3-diphenylprop-2-en-1-one) derivatives that have multiple substitutions on a phenyl ring. Intermediate chalcone derivatives are modified by Phase Transfer Catalysis (PTC) for introducing a substituted alkyl group that is provided by a sulfonic acid derivative on a phenyl ring already containing substituent groups on one or two carbon atoms adjacent to the carbon atom where a substituent group is being introduced. The methods of the invention allow producing efficiently, by either S-alkylation or O-alkylation, chalcones derivatives that are characterized for their biological activities that are intermediate compounds for producing molecules having such activities, or that can be used for generating libraries of compounds to be screened by means of in vitro and/or in vivo assays and establishing structure-activity relationships.

    摘要翻译： 本发明涉及在苯环上具有多个取代基的查尔酮（1,3-二苯基丙-2-烯-1-酮）衍生物的方法。 中间查耳酮衍生物通过相转移催化剂（PTC）进行改性，用于将由磺酸衍生物提供的取代的烷基引入到已经含有一个或两个邻近碳原子上的取代基的取代基的苯环上，其中取代基为 被介绍 本发明的方法允许通过S-烷基化或O-烷基化有效生产由其生物活性表征的作为用于产生具有这种活性的分子的中间体化合物的或可以用于产生化合物文库的查尔酮衍生物 通过体外和/或体内测定法筛选并建立结构 - 活性关系。