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1.发明授权
公开(公告)号：US6123847A
公开(公告)日：2000-09-26
申请号：US137120
申请日：1998-08-20
申请人： Bernard Bene
发明人： Bernard Bene
CPC分类号： A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/165 , A61M1/3437 , A61M1/3458 , A61M2205/3393
摘要： Dialysis apparatus including:structure (14) for preparing a dialysis liquid containing sodium, comprising structure (18) for regulating the sodium concentration;a dialysis liquid circuit comprising a feed line (12) and a discharge line (13), the feed line (12) having one end connected to the structure (14) for preparing dialysis liquid, and another end which can be connected to a dialyser (1), the discharge line (13) having an end which can be connected to the dialyser (1);structure (9, 10, 12) for infusing a patient with an infusion solution containing sodium and a substance A at determined concentrations [Na.sup.+ ]sol and [A]sol;structure (32) for determining the sodium concentration [Na.sup.+ ]dial of the dialysis liquid so that the patient's body tends towards a desired sodium concentration [Na.sup.+ ]des, as a function of the dialysance D of the dialyser (1) for sodium, of the desired sodium concentration [Na.sup.+ ]des inside the patient's body, of the infusion flow rate Qinf, and of the sodium concentration [Na.sup.+ ]sol of the infusion solution;control structure (32) for driving the structure (18) for regulating the sodium concentration of the dialysis liquid such that this concentration is equal to the determined concentration [Na.sup.+ ]dial.
摘要翻译： 透析装置，包括：用于制备含有钠的透析液的结构（14），其包含用于调节钠浓度的结构（18） 透析液体回路，包括进料管线（12）和排出管线（13），所述进料管线（12）的一端连接到用于制备透析液体的结构（14），另一端可连接到透析器 （1），所述排出管（13）具有可连接到所述透析器（1）的端部; 结构（9,10,12），用于向患者注入含有浓度为[Na +]溶胶和[A]溶胶的钠和物质A的输液; 用于确定透析液的钠浓度[Na +]表盘的结构（32），以使得患者的身体倾向于所需的钠浓度[Na +] des，作为钠透析器（1）的透析度D的函数 输液流量Qinf中的所需钠浓度[Na +] des，输液溶液的钠浓度[Na +]溶液） 用于驱动用于调节透析液的钠浓度的结构（18）的控制结构（32），使得该浓度等于确定的浓度[Na +]表盘。
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公开(公告)号：US6039877A
公开(公告)日：2000-03-21
申请号：US934903
申请日：1997-09-22
CPC分类号： A61M1/1656 , A61M1/1672 , A61M1/3465 , A61M2205/707 , A61M2205/7554 , A61M2205/7563
摘要： A device for treatment of blood by extracorporeal circulation comprises a dialysis liquid circuit having a supply tube (9a, 9b) on which is arranged a filter (21) having a first chamber and a second chamber (22, 23) which are separated by a filtering membrane (24), the supply tube having a first portion (9a) connecting a dialysis liquid source (10) to an inlet of the first chamber (22), and a second portion (9b) having an end connected to an outlet of the second chamber (23) of the filter (21) and another end which can be connected to an inlet of a compartment (3) of an exchanger (1) with semipermeable membrane (4). A feedback tube (25) connects the inlet of the first chamber (22) of the filter (21) to the outlet of the first chamber (22). A flushing pump (26) is arranged on the feedback tube (25) for circulating liquid in the first chamber (22) of the filter (21) and causing cleaning of the membrane (24) by tangential flushing.
摘要翻译： 用于通过体外循环治疗血液的装置包括透析液体回路，其具有供给管（9a，9b），所述供给管（9a，9b）上布置有具有第一腔室和第二腔室（22,23）的过滤器（21） 过滤膜（24），所述供应管具有将透析液体源（10）连接到所述第一室（22）的入口的第一部分（9a）和具有连接到所述第一室 过滤器（21）的第二腔室（23）和可以与具有半透膜（4）的交换器（1）的隔室（3）的入口连接的另一端。 反馈管（25）将过滤器（21）的第一室（22）的入口连接到第一室（22）的出口。 在反馈管（25）上布置有用于使过滤器（21）的第一室（22）中的液体循环并且通过切向冲洗来清洁膜（24）的冲洗泵（26）。
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3.发明授权
公开(公告)号：US5744031A
公开(公告)日：1998-04-28
申请号：US942460
申请日：1992-09-09
申请人： Bernard Bene
发明人： Bernard Bene
CPC分类号： A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/165 , A61M1/3458 , Y10S210/929
摘要： An artificial kidney includes measurement structure for measuring at least one physical characteristic of a fresh dialysis liquid and of used liquid. The measurement structure are disposed in a line portion common to a branch circuit to the feeder line of fresh dialysis liquid and to a branch circuit to the discharge line for the used liquid. Occluding structure permit the liquid to circulate exclusively in one or the other branch circuit. Due to this arrangement, it is possible to obtain the value of the physical characteristics of a patient's blood by calculation as frequently as desired, and to adjust the operation of the kidney permanently to a therapeutic objective set by the physician.
摘要翻译： 人造肾包括用于测量新鲜透析液和二手液体的至少一种物理特性的测量结构。 测量结构设置在与新鲜透析液的供给管线的分支电路相同的直线部分中，并配置到用于所使用的液体的排出管线的分支电路。 封闭结构允许液体专门在一个或另一个分支回路中循环。 由于这种安排，可以通过根据需要频繁地计算来获得患者血液的物理特性的值，并且将肾脏的操作永久地调整为由医生设定的治疗目标。
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公开(公告)号：US5702597A
公开(公告)日：1997-12-30
申请号：US462435
申请日：1995-06-05
CPC分类号： A61M1/1656 , A61M1/1672 , A61M1/3465 , A61M2205/707 , A61M2205/7554 , A61M2205/7563
摘要： A device for treatment of blood by extracorporeal circulation comprises a dialysis liquid circuit having a supply tube (9a, 9b) on which is arranged a filter (21) having a first chamber and a second chamber (22, 23) which are separated by a filtering membrane (24), the supply tube having a first portion (9a) connecting a dialysis liquid source (10) to an inlet of the first chamber (22), and a second portion (9b) having an end connected to an outlet of the second chamber (23) of the filter (21) and another end which can be connected to an inlet of a compartment (3) of a dialyzer (1) with semipermeable membrane (4). A feedback tube (25) connects the inlet of the first chamber (22) of the filter (21) to the outlet of the first chamber (22). A flushing pump (26) is arranged on the feedback tube (25) for circulating liquid in the first chamber (22) of the filter (21) and causing cleaning of the membrane (24) by tangential flushing.
摘要翻译： 用于通过体外循环治疗血液的装置包括透析液体回路，其具有供给管（9a，9b），所述供给管（9a，9b）上布置有具有第一腔室和第二腔室（22,23）的过滤器（21） 过滤膜（24），所述供应管具有将透析液体源（10）连接到所述第一室（22）的入口的第一部分（9a）和具有连接到所述第一室 过滤器（21）的第二腔室（23）和可连接到具有半透膜（4）的透析器（1）的隔室（3）的入口的另一端。 反馈管（25）将过滤器（21）的第一室（22）的入口连接到第一室（22）的出口。 在反馈管（25）上布置有用于使过滤器（21）的第一室（22）中的液体循环并且通过切向冲洗来清洁膜（24）的冲洗泵（26）。
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公开(公告)号：US5460446A
公开(公告)日：1995-10-24
申请号：US124459
申请日：1993-09-22
CPC分类号： B01F1/00 , A61M1/1656 , A61M1/1666 , B01F1/0038 , A61M2206/16 , Y10T137/034 , Y10T137/2509 , Y10T137/3109 , Y10T137/4891
摘要： A device for preparing a solution for medical use from a liquid and at least one powdered or crystallized salt, comprising:a main line (11) having a first end connected to a source (10) of liquid and a second end for delivering the solution,at least one secondary line (15, 19; 16, 20) joined as a by-pass to the main line (11), this secondary line comprising a reservoir (13, 14) containing a powdered or crystallized salt and having an inlet opening and an outlet opening situated respectively at a high point and a low point of the reservoir (13, 14),means (12, 21, 22) for causing liquid to circulate in the lines,means (17, 21; 18, 22) for producing the immersion of the powdered or crystallized salt in the reservoir (13, 14).
摘要翻译： 一种用于从液体和至少一种粉末状或结晶盐制备用于医疗用途的溶液的装置，包括：主管线（11），其具有连接到液体源（10）的第一端和用于输送溶液的第二端 ，作为旁路连接到主管线（11）的至少一个次级管线（15,19; 16,20），该次级管线包括容纳粉末状或结晶盐的储存器（13,14），并具有入口 开口和分别位于储存器（13,14）的高点和低点处的出口开口，用于使液体在管线中循环的装置（12,21,22），装置（17,21; 18,22） ），用于将所述粉末状或结晶盐浸入所述储存器（13,14）中。
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公开(公告)号：US5228889A
公开(公告)日：1993-07-20
申请号：US836841
申请日：1992-02-19
CPC分类号： A61M1/1658 , B01D19/00
摘要： A device for eliminating bubbles of gas from a liquid comprises a channel of varying section for the liquid, the channel having a high point for collecting bubbles under gravity, and means for dynamically concentrating bubbles upstream from the high point, said means being constituted by a curved length of the channel situated upstream from the high point. This type of device is used in a variety of technical fields as a component in hydraulic circuits where the presence of bubbles of gas is undesirable.
摘要翻译： 用于从液体中除去气泡的装置包括用于液体的变化部分的通道，通道具有用于在重力作用下收集气泡的高点，以及用于在高点上游动态浓缩气泡的装置，所述装置由 位于高点上游的通道的弯曲长度。 这种类型的装置在各种技术领域中用作液压回路中的组分，其中气体气泡的存在是不期望的。
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公开(公告)号：US5047147A
公开(公告)日：1991-09-10
申请号：US276091
申请日：1988-11-23
申请人： Jacques Chevallet , Olivier Roy
发明人： Jacques Chevallet , Olivier Roy
CPC分类号： A61M1/30 , A61M1/303 , A61M1/306 , A61M1/3431 , A61M1/3437 , A61M1/342
摘要： Artificial kidney of the single-needle type, incorporating an extracorporeal blood circuit provided with a haemodialyser (13) or haemofilter (31) positioned between two blood circulation pumps (12, 19). This circuit is also provided with a bubble trap (18) and a safety clamp (26) and means for perfusing quantities of liquid which are capable of being relatively large. The perfusing means comprise a reservoir (23) and a perfusion pump (24) the motion of which is under the control of the sequential motion of one of the two blood circulation pumps (12, 19) and also comprise a conduit connecting the reservoir (23) to the extracorporeal blood circuit by way of the perfusion pump (24).
摘要翻译： 单针型人造肾，包括设置有位于两个血液循环泵（12,19）之间的血液透析器（13）或血液过滤器（31）的体外血液回路。 该电路还设置有气泡阱（18）和安全钳（26），以及用于灌注能够相对较大的液体的装置。 灌注装置包括储存器（23）和灌注泵（24），其运动处于两个血液循环泵（12,19）之一的连续运动的控制之下，并且还包括连接贮存器（ 23）通过灌注泵（24）到体外血液回路。
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8.发明授权
公开(公告)号：US4767526A
公开(公告)日：1988-08-30
申请号：US703697
申请日：1985-02-21
申请人： Georges Vantard
发明人： Georges Vantard
CPC分类号： A61M1/1694 , A61M1/1696 , A61M2205/3331 , Y10S210/929
摘要： Artificial kidney comprises a hemodialyzer connected in a dialysis liquid circuit which is in the form of a loop the volume of which is essentially invariable. The circuit is open to the atmosphere and comprises a circulating pump arranged upstream of the hemodialyzer. Means are provided for drawing off and measuring, outside the said circuit, amounts of liquid equal to the amounts of ultrafiltrate which it is desired to remove from a patient's blood stream. A variable hydraulic resistance is provided downstream of the hemodialyzer and comprises a float, the resistance being operative to keep the dialysis liquid at an essentially constant level in the circuit in order automatically to regulate the pressure of the dialysis liquid in the hemodialyzer.
摘要翻译： 人造肾包括连接在透析液体回路中的血液透析器，该透析液体回路的体积基本上是不变的。 电路对大气开放，包括一个设置在血液透析器上游的循环泵。 提供用于在所述回路外抽出和测量的装置，其量等于其期望从患者血液流中除去的超滤液的量。 在血液透析器的下游提供可变液压阻力并且包括浮子，所述阻力可操作以将透析液体保持在电路中基本上恒定的水平，以便自动调节血液透析器中透析液体的压力。
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9.发明授权公开(公告)号：US07077961B2
公开(公告)日：2006-07-18
申请号：US10203106
申请日：2001-12-03
申请人： Michel Thomas
发明人： Michel Thomas
CPC分类号： A61L2/0035 , A61L2202/22 , A61M1/16 , B01D63/021 , B01D63/081 , B01D65/022 , B01D67/0088 , B01D67/0097 , B01D2321/346
摘要： The present invention relates to a device for the extracorporeal treatment of blood or plasma, comprising two compartments, one compartment intended for circulating blood or plasma, and one compartment intended for circulating spent liquid, separated by a wet semi-permeable membrane, characterized in that the device has, before and after sterilization, the following technical characteristics: the membrane is impregnated with an aqueous glycerol solution; the aqueous glycerol solution contains from 7% to 15% by weight of glycerol and is free of toxic chemical compounds; the two compartments are purged of the aqueous glycerol solution. The present invention also relates to processes for manufacturing this device.
摘要翻译： 本发明涉及一种用于血液或血浆体外处理的装置，包括两个室，一个用于循环血液或血浆的隔室，以及一个用于循环废液的隔室，用湿半透膜隔开，其特征在于： 该装置在灭菌之前和之后具有以下技术特征：膜用甘油水溶液浸渍; 甘油水溶液含有7〜15重量％的甘油，无毒性化合物; 将两个隔室清除甘油水溶液。 本发明还涉及制造该装置的方法。
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公开(公告)号：US07056458B2
公开(公告)日：2006-06-06
申请号：US09937558
申请日：2001-01-26
申请人： Thierry Crost , Jean-Louis Renaux , Michel Thomas
发明人： Thierry Crost , Jean-Louis Renaux , Michel Thomas
CPC分类号： B01D67/0093 , A61L33/0011 , B01D63/021 , B01D65/022 , B01D71/42 , B01D2321/168 , B01D2321/346
摘要： The invention concerns a non-thrombogenic semipermeable membrane comprising a support semipermeable membrane and an anticoagulant suitable for treating blood and plasma by extracorporeal circulation. The invention is characterized in that: the support membrane is made essentially of a polyacrylinitrile, bearing anionic groups or groups capable of being anionic; the surface of the support semipermeable membrane designed to be in contact with blood or plasma is coated successively with a cationic polymer and an anticoagulant. The invention also concern an exchanger for treating blood or plasma by extracorporeal circulation comprising two sections separated by a non-thrombogenic semipermeable, membrane and a method for making the exchanger.
摘要翻译： 本发明涉及一种非血栓形成的半透膜，其包含支持性半透膜和适合于通过体外循环治疗血液和血浆的抗凝血剂。 本发明的特征在于：支撑膜主要由聚丙烯腈制成，具有阴离子基团或能阴离子基团; 设计为与血液或血浆接触的支撑半透膜的表面依次用阳离子聚合物和抗凝剂涂覆。 本发明还涉及一种用于通过体外循环治疗血液或血浆的交换器，其包括由非血栓形成的半透膜，膜分离的两个部分和用于制备交换器的方法。
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