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公开(公告)号:US20220196663A1
公开(公告)日:2022-06-23
申请号:US17611351
申请日:2020-06-09
申请人: SANFORD HEALTH , INANOVATE, INC.
发明人: Kristi EGLAND , Rick EVANS , Eagappanath THIRUPPATHI , David URE , Matt KOSTURA , Etienne Z. GNIMPIEBA
IPC分类号: G01N33/574
摘要: Methods and related reagents are disclosed for diagnosing cancer, prognosing cancer occurrence or recurrence, and/or monitoring cancer therapy, involving contacting a bodily fluid sample from a subject at risk of having cancer or cancer recurrence, or from a subject that has been treated for cancer wl fit (a) one or more first antibody detection marker molecules that hind to human autoantibodies against at least one tumor associated antigen (TAA); and (fa) one or more second antibody detection marker molecules that bind to human autoantibodies against at least one extractable nuclear antigen (ENA).
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公开(公告)号:US08975087B2
公开(公告)日:2015-03-10
申请号:US12956117
申请日:2010-11-30
申请人: James Curtis Nelson , David Ure
发明人: James Curtis Nelson , David Ure
IPC分类号: G01N33/543 , F04B43/00 , F04B43/02 , F04B43/04 , F04B43/06
CPC分类号: G01N33/557 , B01L3/50273 , B01L2300/0816 , B01L2300/123 , F04B43/0009 , F04B43/02 , F04B43/04 , F04B43/06 , G01N33/5302
摘要: Embodiments of the invention include methods for detecting and determining the concentrations of macro and small molecules, including bio-molecules, in a liquid or gaseous sample.
摘要翻译: 本发明的实施方案包括用于检测和测定液体或气体样品中的大分子和小分子(包括生物分子)的浓度的方法。
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公开(公告)号:US20130236335A1
公开(公告)日:2013-09-12
申请号:US13989642
申请日:2011-03-29
申请人: James Curtis Nelson , David Ure
发明人: James Curtis Nelson , David Ure
IPC分类号: F04B43/00
CPC分类号: G01N33/557 , B01L3/50273 , B01L2300/0816 , B01L2300/123 , F04B43/0009 , F04B43/02 , F04B43/04 , F04B43/06 , G01N33/5302
摘要: Embodiments of the invention relate generally to devices and methods for pumping and controling the flow of a fluid. More particularly, embodiments of the invention relate to capacitive pumping and flow control devices and methods. In one embodiment, the invention provides a pump system having an inlet valve, an outlet valve, and a chamber between and in communication with each of the inlet valve and the outlet valve, the chamber having at least one elastic surface, wherein the chamber will dilate in response to a fluid exerting a pressure on the elastic surface, contain a quantity of the fluid when so dilated, and discharge the quantity of the fluid through the opened outlet valve.
摘要翻译: 本发明的实施例一般涉及用于泵送和控制流体流动的装置和方法。 更具体地,本发明的实施例涉及电容式泵送和流量控制装置和方法。 在一个实施例中,本发明提供了一种泵系统,其具有入口阀,出口阀和在每个入口阀和出口阀之间并与之连通的室,所述室具有至少一个弹性表面,其中所述室将 响应于在弹性表面上施加压力的流体膨胀,当膨胀时含有一定量的流体,并且通过打开的出口阀排出流体的量。
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公开(公告)号:US20120129271A1
公开(公告)日:2012-05-24
申请号:US12956117
申请日:2010-11-30
申请人: James Curtis Nelson , David Ure
发明人: James Curtis Nelson , David Ure
CPC分类号: G01N33/557 , B01L3/50273 , B01L2300/0816 , B01L2300/123 , F04B43/0009 , F04B43/02 , F04B43/04 , F04B43/06 , G01N33/5302
摘要: Embodiments of the invention relate generally to macro and small molecule detection and, more particularly, to methods for detecting macro and small molecules, including bio-molecules, in a liquid or gaseous sample. Methods according to embodiments of the invention are useful in the identification, discovery, and validation of biomarkers, as well as the screening of individuals for such biomarkers for diagnostic, therapeutic, and forensic purposes. In one embodiment, the invention provides a method of detecting an analyte in a fluid sample, the method comprising: passing a fluid sample containing a labeled analyte across at least one assay surface containing a capture agent for the analyte; detecting the labeled analyte; repeating the passing and detecting steps at least once; and creating a binding curve for the analyte based on the detecting of the labeled analyte.
摘要翻译: 本发明的实施方案一般涉及宏观和小分子检测,更具体地涉及在液体或气体样品中检测包括生物分子在内的大分子和小分子的方法。 根据本发明的实施方案的方法可用于生物标志物的鉴定,发现和验证,以及用于诊断,治疗和法医目的的这些生物标志物的个体筛选。 在一个实施方案中,本发明提供了检测流体样品中的分析物的方法,所述方法包括:将含有标记分析物的流体样品通过至少一个含有分析物捕获剂的测定表面; 检测标记的分析物; 重复通过和检测步骤至少一次; 并根据检测标记的分析物产生分析物的结合曲线。
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公开(公告)号:US20230314430A1
公开(公告)日:2023-10-05
申请号:US17996478
申请日:2021-04-02
申请人: INANOVATE, INC.
发明人: David URE
IPC分类号: G01N33/569 , G01N33/543
CPC分类号: G01N33/56983 , G01N33/54386 , G01N2333/165 , G01N2469/20
摘要: The invention relates generally to serology assays and, more particularly, to high-throughput serology assays. One aspect of the invention provides a method of detecting a viral antibody in a biological sample of an individual, the method comprising: applying an antigen-containing fluid to an assay surface, the antigen-containing fluid containing an antigen for the vims to be detected and the assay surface containing a biological sample from the individual; removing the antigen-containing fluid from the assay surface; and determining whether the assay surface contains bound antigen.
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公开(公告)号:US08288162B2
公开(公告)日:2012-10-16
申请号:US11729510
申请日:2007-03-28
申请人: David A. Ure , Richard E. Palmer
发明人: David A. Ure , Richard E. Palmer
CPC分类号: G01N33/574 , B01J19/0046 , B01J2219/00572 , B01J2219/00648 , B01J2219/00659 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , G01N21/554 , G01N33/54346 , G01N33/54353 , G01N33/5436 , G01N33/551 , Y10T428/25
摘要: The present invention relates to a nano-particle biochip substrate comprising a substrate having attached thereto (bearing), on or in a surface, nano-particles having a cross sectional diameter of from about 0.1 nm. to about 50 nm. and useful to immobilize one or more moieties of interest.
摘要翻译: 本发明涉及一种纳米颗粒生物芯片衬底,其包括在其表面上附着有(表面)基底,其表面具有约0.1nm的横截面直径的纳米颗粒。 至约50nm。 并且可用于固定一个或多个感兴趣的部分。
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公开(公告)号:US10060919B2
公开(公告)日:2018-08-28
申请号:US14603329
申请日:2015-01-22
申请人: Inanovate, Inc.
发明人: James Curtis Nelson , David Ure
CPC分类号: G01N33/557 , B01L3/50273 , B01L2300/0816 , B01L2300/123 , F04B43/0009 , F04B43/02 , F04B43/04 , F04B43/06 , G01N33/5302
摘要: The invention relates to macro and small molecule detection and, more particularly, to methods for detecting macro and small molecules, including bio-molecules, in a liquid or gaseous sample.
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公开(公告)号:US09874559B2
公开(公告)日:2018-01-23
申请号:US13989642
申请日:2011-03-29
申请人: James Curtis Nelson , David Ure
发明人: James Curtis Nelson , David Ure
CPC分类号: G01N33/557 , B01L3/50273 , B01L2300/0816 , B01L2300/123 , F04B43/0009 , F04B43/02 , F04B43/04 , F04B43/06 , G01N33/5302
摘要: Embodiments of the invention relate generally to devices and methods for pumping and controlling the flow of a fluid. More particularly, embodiments of the invention relate to capacitive pumping and flow control devices and methods. In one embodiment, the invention provides a pump system having an inlet valve, an outlet valve, and a chamber between and in communication with each of the inlet valve and the outlet valve, the chamber having at least one elastic surface, wherein the chamber will dilate in response to a fluid exerting a pressure on the elastic surface, contain a quantity of the fluid when so dilated, and discharge the quantity of the fluid through the opened outlet valve.
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