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公开(公告)号：US11890393B2
公开(公告)日：2024-02-06
申请号：US17138703
申请日：2020-12-30
IPC分类号： A61B17/11 , A61F2/00 , A61F2/02 , A61K9/00 , A61L27/52 , A61L31/14 , A61B17/00 , A61L27/26 , A61L27/18
CPC分类号： A61L27/26 , A61B17/1128 , A61F2/00 , A61F2/02 , A61K9/0004 , A61L27/18 , A61L27/52 , A61L31/14 , A61B2017/00526 , A61F2210/00 , A61F2210/008 , A61F2240/00 , A61F2240/001 , A61F2250/00 , A61L2400/06 , A61L2430/32
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.
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公开(公告)号：US11648021B2
公开(公告)日：2023-05-16
申请号：US16442521
申请日：2019-06-16
申请人： Incept, LLC
IPC分类号： A61B17/221 , A61B17/22 , A61F2/01 , A61B17/00 , A61M1/36
CPC分类号： A61B17/221 , A61B2017/00862 , A61B2017/2212 , A61B2017/22035 , A61B2017/22038 , A61F2002/016 , A61F2002/018 , A61F2230/0069 , A61M1/3655
摘要： An apparatus and method for capturing material within a body lumen are disclosed. The apparatus includes a core wire extending from a proximal end to a distal tip, an actuator member defining a lumen for receiving at least a portion of the core wire, and a distal basket having a distal enclosed end fixed relative to the core wire and one or more elements extending from a proximal open end to a collar slidable on the core wire. The collar is slidable on the core wire within an interior of the distal basket such that, when the collar contacts the actuator member, the collar applies an inward force to direct the proximal open end of the distal basket radially inwardly.
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公开(公告)号：US20220370419A1
公开(公告)日：2022-11-24
申请号：US17830968
申请日：2022-06-02
申请人： Incept, LLC
发明人： Peter Jarrett , Rami El-Hayek , Timothy S. Jarrett , Charles D. Blizzard , Amarpreet S. Sawhney
IPC分类号： A61K31/436 , A61K31/44 , A61K31/404 , A61K31/502 , A61K31/496 , A61K31/56 , A61K31/517 , A61K31/444 , A61K9/00
摘要： Drug delivery involving hydrogels as used for various medical conditions, and includes hydrogels formed in an eye with extended drug release times. An embodiment of the invention is a method of delivering a therapeutic agent to a tissue comprising forming a hydrogel in situ in an eye with a therapeutic agent dispersed in the hydrogel, the agent having a low solubility in water. The agent may be essentially insoluble in water. The hydrogel may be made so that 50% to 100% w/w of the agent is released when the hydrogel is from 100% to 50% persistent, with the persistence being a measure of the dry weight of the hydrogel relative to an initial dry weight of the hydrogel.
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公开(公告)号：US20220054705A1
公开(公告)日：2022-02-24
申请号：US17477947
申请日：2021-09-17
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth
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公开(公告)号：US11160883B2
公开(公告)日：2021-11-02
申请号：US16817297
申请日：2020-03-12
申请人： Incept, LLC
摘要： Implantable materials visible under ultrasound may be delivered to a selected placement site and biodegrade after a certain period of time. Ultrasound visible implantable materials may be delivered through an applicator and may include ultrasound contrast agents and/or radiopaque agents. Applications include monitoring the delivery of an implant of the implantable materials to the placement site with ultrasound and delivery of therapeutic agents to a tissue at the placement site for treating a patient.
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公开(公告)号：US20210268141A1
公开(公告)日：2021-09-02
申请号：US17174476
申请日：2021-02-12
申请人： Incept, LLC
摘要： Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.
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公开(公告)号：US20210177975A1
公开(公告)日：2021-06-17
申请号：US17131242
申请日：2020-12-22
申请人： Incept, LLC
摘要： Serial-solvent biomaterials are described. Embodiments include materials made in an organic solvent that are stripped of the solvent and used in a patient, where they imbibe water and form a hydrogel. These materials are useful for, among other things, delivering therapeutic agents, tissue augmentation, and radiological marking.
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公开(公告)号：US20210128478A1
公开(公告)日：2021-05-06
申请号：US16999504
申请日：2020-08-21
申请人： Incept, LLC
发明人： Peter Jarrett , Michael J. McGrath , Timothy S. Jarrett , Rami El-Hayek , Andrew C. Vanslette , Courtney A. Rosales , Charles D. Blizzard , Amarpreet S. Sawhney
IPC分类号： A61K9/20 , A61K47/10 , A61K9/00 , A61K31/4439
摘要： Drug delivery using bio-affecting drugs, particularly with shape changing drug delivery devices. Embodiments are included for depots for delivery of a therapeutic agent that change from an elongated state ex vivo to a coil in vivo where the agent is released.
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公开(公告)号：US20210100657A1
公开(公告)日：2021-04-08
申请号：US17027368
申请日：2020-09-21
申请人： Incept, LLC
发明人： Fred Khosravi , Gerard von Hoffmann
摘要： Methods and devices are disclosed for treating neurovascular venous outflow obstructions, with or without implantation of a prosthetic valve. The valve may be carried by a support, such as a stent, which may be self-expandable or balloon expandable. Both transvascular and direct surgical access is contemplated.
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公开(公告)号：US09775906B2
公开(公告)日：2017-10-03
申请号：US12485192
申请日：2009-06-16
IPC分类号： A61K47/10 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58 , A61K9/06 , A61K31/445 , A61K9/00
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/445 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58
摘要： Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
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