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公开(公告)号：US09775906B2
公开(公告)日：2017-10-03
申请号：US12485192
申请日：2009-06-16
IPC分类号： A61K47/10 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58 , A61K9/06 , A61K31/445 , A61K9/00
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/445 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58
摘要： Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
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公开(公告)号：US09125807B2
公开(公告)日：2015-09-08
申请号：US11825848
申请日：2007-07-09
IPC分类号： A61K47/10 , A61K9/00 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/445 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58
摘要： Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
摘要翻译： 本公开的一些方面涉及治疗影响患者眼睛的眼科疾病的方法，包括在眼周，眼内或玻璃体外部位置原位形成共价交联的水凝胶，以控制释放治疗 代理商
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公开(公告)号：US07862538B2
公开(公告)日：2011-01-04
申请号：US12012606
申请日：2008-02-04
IPC分类号： A61M37/00
CPC分类号： A61B17/0057 , A61B2017/00495 , A61B2017/0065
摘要： Described herein are systems for packaging dual or multiple-component adhesive systems that provide enhanced convenience and efficacy. In one aspect, the components of such a system may be divided into containers that allow for foolproof mixing schemes to avoid mixing the wrong components while also providing a sterile surface for mixing materials, with the sterile surface having optimal physical properties for mixing the materials, especially in small amounts. Certain embodiments include a surgical delivery system for a medical sealant including a packaging system with a detachable a sterile surface for mixing the sealant as needed for application.
摘要翻译： 本文描述的是用于包装双组分或多组分粘合剂体系的系统，其提供增强的便利性和有效性。 在一个方面，这种系统的组件可以被分成容器，其允许防混合方案以避免混合错误的组分，同时还提供用于混合材料的无菌表面，无菌表面具有用于混合材料的最佳物理性质， 特别是少量。 某些实施方案包括用于医用密封剂的手术递送系统，其包括具有可拆卸无菌表面的包装系统，用于根据需要混合密封剂。
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公开(公告)号：US20090252781A1
公开(公告)日：2009-10-08
申请号：US12485192
申请日：2009-06-16
IPC分类号： A61F2/00 , A61K9/10 , A61K38/00 , A61K31/7088
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/445 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58
摘要： Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
摘要翻译： 本公开的一些方面涉及治疗影响患者眼睛的眼科疾病的方法，包括在眼周，眼内或玻璃体外部位置原位形成共价交联的水凝胶，以控制释放治疗 代理商
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公开(公告)号：US20090198177A1
公开(公告)日：2009-08-06
申请号：US12012606
申请日：2008-02-04
IPC分类号： A61M37/00
CPC分类号： A61B17/0057 , A61B2017/00495 , A61B2017/0065
摘要： Certain embodiments include a surgical delivery system for a medical sealant including a packaging system with a detachable a sterile surface for mixing the sealant as needed for application.
摘要翻译： 某些实施方案包括用于医用密封剂的手术递送系统，其包括具有可拆卸的无菌表面的包装系统，用于根据需要混合密封剂。
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公开(公告)号：US20090017097A1
公开(公告)日：2009-01-15
申请号：US11825848
申请日：2007-07-09
IPC分类号： A61K9/10 , A61K31/7088 , A61K9/127 , A61P27/00 , A61K38/00
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/445 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58
摘要： Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
摘要翻译： 本公开的一些方面涉及治疗影响患者眼睛的眼科疾病的方法，包括在眼周，眼内或玻璃体外部位置原位形成共价交联的水凝胶，以控制释放治疗 代理商
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公开(公告)号：US09254267B2
公开(公告)日：2016-02-09
申请号：US12218152
申请日：2008-07-11
申请人： Amarpreet S. Sawhney
发明人： Amarpreet S. Sawhney
CPC分类号： A61K9/1647 , A61K9/167 , A61K9/2077 , A61K51/1213
摘要： Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.
摘要翻译： 提供组合物和方法以通过首先将这种治疗物质分散或溶解在相对疏水的速率调节剂中以形成混合物来控制通过水凝胶释放相对低分子量的治疗物质。 将混合物形成分散在生物可吸收的水凝胶中的微粒，以便以受控的方式释放水溶性治疗剂。 还提供了在治疗系统中使用本发明组合物的方法。
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公开(公告)号：US08512749B2
公开(公告)日：2013-08-20
申请号：US10795132
申请日：2004-03-05
CPC分类号： A61K9/0075 , A61K9/7023 , A61K47/34
摘要： Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
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公开(公告)号：US20110142936A1
公开(公告)日：2011-06-16
申请号：US12968527
申请日：2010-12-15
CPC分类号： A61K49/0442 , A61K49/0419 , A61K51/1244 , A61K2123/00 , A61L27/50 , A61L27/52 , A61L27/58 , A61L31/145 , A61L31/148 , A61L31/18
摘要： Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.
摘要翻译： 可植入材料可用于医源性部位。 应用范围包括用于基准标记的放射性斑块材料。
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公开(公告)号：US20110066183A1
公开(公告)日：2011-03-17
申请号：US12876980
申请日：2010-09-07
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61K9/0024 , A61L26/0052 , A61L26/008 , A61L27/58 , A61L31/042 , A61L31/044 , A61L31/046 , A61L31/048 , A61L31/06 , A61L31/145 , A61L31/148 , A61L2300/232 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2420/06 , C08L71/02
摘要： Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
摘要翻译： 用于密封与血管连通的穿刺的装置包括由冻干的水凝胶或其它材料形成的多孔载体。 插塞可以在暴露于水性生理环境之前至少包括第一和第二水凝胶前体和由多孔载体承载的非调节状态的pH调节剂。 一旦暴露于体液，载体会随着冻干物质的水合而膨胀，以增强和促进穿刺的快速止血。 当塞子被置于穿刺中时，由体液（例如血液）引起的塞子的自然润湿使得第一和第二前体反应并交联成粘合剂或“粘性”水凝胶，其有助于保持塞子 穿刺的地方
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