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公开(公告)号：US08829096B2
公开(公告)日：2014-09-09
申请号：US13762964
申请日：2013-02-08
申请人： Invibio Limited
发明人： Marcus Jarman-Smith
CPC分类号： C08K3/40 , B29C67/202 , C08J9/26 , C08J2201/0446 , C08J2207/10 , C08J2371/12
摘要： An upright column is packed with particles of a first material so the particles touch one another and a network of voids is defined between the particles. The network will be substantially continuous. A second material is then introduced into the column so the second material penetrates the network and fills the voids. The mixture of first and second materials is then consolidated using heat to melt the first or second material, while the other one of the first or second material remains in a solid state and acts as a space holder. Thereafter, the material which acts as the space holder may be removed thereby to leave a substantially continuous porous network defined by the material which was melted. It is found that, by use of the method, a substantially continuous network of the material which is melted can be formed and that the other material can readily be removed and/or is more easily removed compared to if a mixture of first and second materials was formed prior to packing in a column or mold.
摘要翻译： 竖立的柱子填充有第一材料的颗粒，使得颗粒彼此接触，并且在颗粒之间限定空隙网络。 网络将基本连续。 然后将第二材料引入柱中，使得第二材料渗透网络并填充空隙。 然后使用热量固化第一和第二材料的混合物以熔化第一或第二材料，而第一或第二材料中的另一个保持固体状态并用作空间保持器。 此后，作为空间保持器的材料可以被去除，从而留下由被熔化的材料限定的基本连续的多孔网。 发现通过使用该方法，可以形成熔融材料的基本上连续的网络，并且与第一和第二材料的混合物相比，可以容易地除去和/或更容易地除去其它材料 在包装在柱子或模具中之前形成。
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公开(公告)号：US08729150B2
公开(公告)日：2014-05-20
申请号：US13124300
申请日：2009-10-14
IPC分类号： A61F2/28
CPC分类号： A61L27/446 , C08K3/40
摘要： Granules or pellets comprising polymeric materials such as polyaryletherketones and ceramic materials may be prepared and used to make a variety of different parts of components for use in medical applications, by melt-processing. The ceramic material may be a bioactive glass and/or a controlled-release glass, and may include less than 20 mole % sodium oxide and/or be water soluble.
摘要翻译： 可以制备包含聚合物材料如聚芳醚酮和陶瓷材料的颗粒或丸粒，并用于通过熔融加工制备用于医疗应用的各种不同部件组分。 陶瓷材料可以是生物活性玻璃和/或控释玻璃，并且可以包括小于20摩尔％的氧化钠和/或水溶性。
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公开(公告)号：US20110151259A1
公开(公告)日：2011-06-23
申请号：US13054227
申请日：2009-07-14
CPC分类号： C08J9/26 , C08J3/203 , C08J2201/044 , C08J2201/0442 , C08J2201/0444 , C08J2371/10 , Y10T428/2982
摘要： Pellets or granules comprise polymeric material, for example polyetheretherketone and a fugitive material, for example sodium chloride. The granules may be used in injection moulding to produce shapes for use in medical implants and may conveniently be used to form parts which are partially porous, or to prepare porous films.
摘要翻译： 颗粒或颗粒包括聚合物材料，例如聚醚醚酮和短效材料，例如氯化钠。 颗粒可以用于注射成型以产生用于医用植入物的形状，并且可以方便地用于形成部分多孔的部件或制备多孔膜。
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公开(公告)号：US20090326673A1
公开(公告)日：2009-12-31
申请号：US12447319
申请日：2007-10-11
申请人： John Neil Devine , Irene Sinz
发明人： John Neil Devine , Irene Sinz
CPC分类号： C08L71/10 , A61L27/18 , A61L27/44 , A61L27/443 , A61L27/446 , A61L27/48 , C08G2650/40 , C08L71/00
摘要： An assembly comprises first and second parts which bear against one another, wherein said first part comprises a polyetherketoneketone and said second part comprises a polyetherketoneketone. The parts bear against one another such that one or both of the parts may have a tendency to wear and/or produce wear debris by virtue of contact between the parts. The materials used, however, minimise wear and the production of such wear debris.
摘要翻译： 组件包括彼此相对的第一和第二部分，其中所述第一部分包括聚醚酮酮，所述第二部分包含聚醚酮酮。 这些部件彼此抵靠，使得一个或两个部件可能由于部件之间的接触而具有磨损和/或产生磨损碎屑的倾向。 然而，使用的材料最小化磨损和生产这种磨损碎屑。
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公开(公告)号：US20120203317A1
公开(公告)日：2012-08-09
申请号：US13382071
申请日：2010-07-02
CPC分类号： A61N1/375 , A61N1/3787 , C08G2650/40 , C08L71/00 , C08L81/06 , Y10T29/49826
摘要： An enclosure of an active implantable device comprises a composite material which comprises a first layer of a polyetheretherketone film, a second layer of polyetheretherketone film (8) and, sandwiched between, a third layer comprising titanium. The arrangement may be provided in various embodiments such as comprising housing halves (70,72) and a lid (74), each being made of the three layers described. In one embodiment, a communications window may be provided which has a thinner layer of titanium, to facilitate communications between the outside and electrical components positioned within the enclosure.
摘要翻译： 活性可植入装置的外壳包括复合材料，该复合材料包括第一层聚醚醚酮膜，第二层聚醚醚酮膜（8），夹在第三层钛之间。 该布置可以在各种实施例中提供，例如包括壳体半部（70,72）和盖（74），每个由所述三层制成。 在一个实施例中，可以提供通信窗口，其具有较薄的钛层，以便于位于外壳内的外部和电气部件之间的通信。
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公开(公告)号：US20120101185A1
公开(公告)日：2012-04-26
申请号：US13265601
申请日：2010-04-16
CPC分类号： A61L27/18 , A61L27/446 , C08L71/00
摘要： The use of barium sulphate for increasing the impact strength of a polyaryletherketone and/or a polyarylethersulphone involves compounding the barium sulphate with the polymeric material and including water in the composition prepared. The material may be used in implantable prostheses.
摘要翻译： 使用硫酸钡来增加聚芳醚酮和/或聚芳醚砜的冲击强度包括在制备的组合物中将硫酸钡与聚合物材料混合并包括水。 该材料可用于可植入的假体。
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公开(公告)号：US20110230590A1
公开(公告)日：2011-09-22
申请号：US13124300
申请日：2009-10-14
CPC分类号： A61L27/446 , C08K3/40
摘要： Granules or pellets comprising polymeric materials such as polyaryletherketones and ceramic materials may be prepared and used to make a variety of different parts of components for use in medical applications, by melt-processing. The ceramic material may be a bioactive glass and/or a controlled-release glass, and may include less than 20 mole % sodium oxide and/or be water soluble.
摘要翻译： 可以制备包含聚合物材料如聚芳醚酮和陶瓷材料的颗粒或丸粒，并用于通过熔融加工制备用于医疗应用的各种不同部件组分。 陶瓷材料可以是生物活性玻璃和/或控释玻璃，并且可以包括小于20摩尔％的氧化钠和/或水溶性。
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公开(公告)号：US09629697B2
公开(公告)日：2017-04-25
申请号：US14360685
申请日：2012-11-22
申请人： INVIBIO LIMITED
发明人： Nuno Sereno , Marcus Jarman-Smith
CPC分类号： G05B19/182 , A61C13/0004 , A61C13/0022 , A61C13/01 , A61K6/087 , G05B2219/2647 , C08L71/10
摘要： A framework for a removable, partial or complete prosthodontic device is made by machining, using a CAD/CAM technique, a disc 2, made from polyetheretherketone, to define the framework 4. Prosthetic teeth and gums can be secured to the framework to define the prosthodontic device.
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公开(公告)号：US20140228497A1
公开(公告)日：2014-08-14
申请号：US13762964
申请日：2013-02-08
申请人： INVIBIO LIMITED
发明人： Marcus Jarman-Smith
CPC分类号： C08K3/40 , B29C67/202 , C08J9/26 , C08J2201/0446 , C08J2207/10 , C08J2371/12
摘要： An upright column is packed with particles of a first material so the particles touch one another and a network of voids is defined between the particles. The network will be substantially continuous. A second material is then introduced into the column so the second material penetrates the network and fills the voids. The mixture of first and second materials is then consolidated using heat to melt the first or second material, whilst the other one of the first or second material remains in a solid state and acts as a space holder. Thereafter, the material which acts as the space holder may be removed thereby to leave a substantially continuous porous network defined by the material which was melted. It is found that, by use of the method, a substantially continuous network of the material which is melted can be formed and that the other material can readily be removed and/or is more easily removed compared to if a mixture of first and second materials was formed prior to packing in a column or mould.
摘要翻译： 竖立的柱子填充有第一材料的颗粒，使得颗粒彼此接触，并且在颗粒之间限定空隙网络。 网络将基本连续。 然后将第二材料引入柱中，使得第二材料渗透网络并填充空隙。 然后使用热固化第一和第二材料的混合物以熔化第一或第二材料，而第一或第二材料中的另一个保持固体状态并用作空间保持器。 此后，作为空间保持器的材料可以被去除，从而留下由被熔化的材料限定的基本连续的多孔网。 发现通过使用该方法，可以形成熔融材料的基本上连续的网络，并且与第一和第二材料的混合物相比，可以容易地除去和/或更容易地除去其它材料 在包装在柱子或模具中之前形成。
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公开(公告)号：US20140200466A1
公开(公告)日：2014-07-17
申请号：US14128686
申请日：2012-06-21
CPC分类号： A61L31/06 , A61B5/6869 , A61L27/18 , A61N1/36 , C08G2650/40 , C08L71/00 , C08L81/06 , Y10T428/24479
摘要： Topographical features, such as projections or recesses, having a maximum dimension which is less than 3 μm, with the features being separated by a distance which is less than 10 μm are transferred to polyetheretherketone, on an industrial scale, by injection moulding relatively low viscosity PEEK, using a mould in which is arranged a master structure which carries the desired topography. The topographical features increase the water contact angle of a surface which includes them and such a modified surface has been shown to influence cell attachment and differentiation. Parts which incorporate the topographical features may be used in medical devices such as implantable medical devices for cardiology or for neuromodulation.
摘要翻译： 具有小于3μm的最大尺寸的形状特征，例如具有小于10μm的距离的特征被放置在工业规模上，通过注塑相对低的粘度转移到聚醚醚酮 PEEK，使用其中布置有携带所需形貌的主结构的模具。 形貌特征增加包括它们的表面的水接触角，并且已经显示这种改性表面影响细胞附着和分化。 结合地形特征的部件可以用于诸如用于心脏病学的植入式医疗装置或用于神经调节的医疗装置中。
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