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公开(公告)号：US20240180827A1
公开(公告)日：2024-06-06
申请号：US18553141
申请日：2022-03-29
发明人： Yuki YAMASHITA
IPC分类号： A61K9/10 , A61K9/00 , A61K31/353 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/38 , A61K47/44
CPC分类号： A61K9/10 , A61K9/0048 , A61K31/353 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/38 , A61K47/44
摘要： The present disclosure provides suspendable ophthalmic solutions with excellent redispersibility. The present disclosure provides an aqueous suspension agent comprising (E)-2-(7-trifluoromethylchroman-4-ylidene)-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide or a pharmaceutically acceptable salt or solvate thereof, a cellulosic polymer, and a nonionic surfactant.
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公开(公告)号：US20230190943A1
公开(公告)日：2023-06-22
申请号：US18163650
申请日：2023-02-02
发明人： Shoji FURUSAKO , Isao SAKURADA
IPC分类号： A61K47/61 , A61K47/65 , A61K31/192 , A61K31/196 , A61K47/36
CPC分类号： A61K47/61 , A61K31/192 , A61K31/196 , A61K47/36 , A61K47/65 , A61K9/06
摘要： Provided is water-soluble compound that can be used in a sustained-release preparation and is capable of stably releasing a fixed amount of an active ingredient in vivo by using the novel potential base material option of alginic acid as the base material. The present invention relates to an alginic acid derivative having a structure which is obtained by covalently bonding a nonsteroidal anti-inflammatory compound and alginic acid or a salt thereof via a linker, and preferably relates to an alginic acid derivative represented by formula (1) (in the formula: (A) represents one residue derived from alginic acid or a salt thereof and having the C(═O)— group from either L-guluronic acid or D-mannuronic acid, the monosaccharides that constitute alginic acid; (D) represents one residue from a nonsteroidal anti-inflammatory compound; and -L- represents a linker having a functional group which is capable of bonding to (A) by means of an amide bond and having a functional group which is capable of bonding to (D) by means of an ester bond).
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公开(公告)号：US11648229B2
公开(公告)日：2023-05-16
申请号：US17076090
申请日：2020-10-21
发明人： Nobushige Doisaki , Shingo Arato , Takuro Fukae
IPC分类号： A61K31/20 , A61K31/232 , C07C67/03 , C07C67/54 , C07C67/56 , C07C69/587 , C11B3/12 , C11C3/10
CPC分类号： A61K31/232 , C07C67/03 , C07C67/54 , C07C67/56 , C07C69/587 , C11B3/12 , C11C3/10
摘要： Provided are: a composition containing 96-99 area % of eicosapentaenoic acid alkyl ester, the composition having an arachidonic acid alkyl ester content of 0.7 area % or less, and an eicosapentaenoic-acid-alkyl-ester mono-trans isomer content of 2.5 area % or less; and a method for producing a composition containing a high concentration of eicosapentaenoic acid alkyl ester, the method including performing precision distillation on a composition containing eicosapentaenoic acid alkyl ester, obtained by alkyl esterification of a raw material oil containing eicosapentaenoic acid, under a vacuum of 0.2 Torr or lower and a temperature of 190° C. or lower in the entire column, and performing a concentration treatment on the precision-distilled composition using chromatography.
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公开(公告)号：US20230145308A1
公开(公告)日：2023-05-11
申请号：US17896474
申请日：2022-08-26
发明人： Taichi ITO , Seiichi OHTA , Norihiro KOKUDO , Mitsuko ISAJI , Satoshi SHIMIZU
CPC分类号： A61B90/08 , A61L31/14 , A61L31/12 , A61L31/04 , A61L31/128 , A61L31/146 , A61B2090/0816 , A61L2420/08
摘要： An adhesion-preventing material having a high adhesion-preventing effect has been demanded. An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.
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公开(公告)号：US20230045844A1
公开(公告)日：2023-02-16
申请号：US17792099
申请日：2021-01-13
发明人： Tomokazu TAKAI , Hitoshi MIZUNO , Akira TAKAHASHI , Toshiya ENDO , Shinichi SAKAUE , Norimasa IWASAKI , Tomohiro ONODERA , Koji IWASAKI
IPC分类号： A61K31/734 , A61K9/06 , A61L27/20 , A61L27/52 , A61P19/04
摘要： Realized is reliable fixation of a material in a fluid state containing a monovalent metal salt of alginic acid when the material is applied to a subject. A combination of compositions comprising a first material composition containing a monovalent metal salt of alginic acid and a second material composition containing a cross-linking agent having an action of cross-linking the monovalent metal salt of alginic acid, wherein the combination is to be used in such a way as to apply the first material composition to a subject in a fluid state and contact the second material composition with the first material composition applied to the subject to gel at least a part of the first material composition, wherein the first material composition further contains a coloring component so that a formation state of a gel coat on a surface of the first material composition applied to the subject can be evaluated.
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公开(公告)号：US20230041137A1
公开(公告)日：2023-02-09
申请号：US17792028
申请日：2021-01-13
发明人： Hitoshi MIZUNO , Kuniyoshi MASUDA , Masahiko KATAYAMA , Tomokazu TAKAI , Toshiya ENDO , Norimasa IWASAKI , Tomohiro ONODERA , Koji IWASAKI
IPC分类号： A61B17/02
摘要： A retractor is provided that can form a joint cavity internal space for a field of view for an endoscope and practice of a treatment in a state where a wound area is spread. A retractor includes first arm portions 2 and 3 and a second arm portion 4 positioned between the first arm portions 2 and 3. The first arm portions 2 and 3 include first claw portions 12 and 13 to be hung on a wound area entrance edge. The second arm portion 4 includes a second claw portion 14 to be hung on the wound area entrance edge. When the first arm portions 2 and 3 and the second arm portion 4 are in a closed state, the first claw portions 12 and 13 and the second claw portion 14 overlap with each other.
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公开(公告)号：US20220280468A1
公开(公告)日：2022-09-08
申请号：US17826389
申请日：2022-05-27
IPC分类号： A61K31/232 , A61P9/00
摘要： Disclosed is method using a composition is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular event occurring in a hypercholesterolemia patient despite providing the patient with a treatment with HMG-CoA RI or a cardiovascular event occurring in a multiple risk patient.
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公开(公告)号：US11426425B2
公开(公告)日：2022-08-30
申请号：US16489436
申请日：2018-03-01
IPC分类号： A61L26/00 , A61K31/734 , A61P19/04 , A61K9/00 , A61K9/19
摘要： The present invention has an objective of providing a novel composition for treating a fibrocartilaginous tissue injury. The present invention provides a composition for treating a fibrocartilaginous tissue injury, which is to be applied to an injured fibrocartilaginous tissue part of a target and which comprises a monovalent metal salt of alginic acid, more preferably a low endotoxin monovalent metal salt of alginic acid.
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公开(公告)号：US20220009898A1
公开(公告)日：2022-01-13
申请号：US17486265
申请日：2021-09-27
发明人： Hideharu UCHIDA , Tsutomu SATOH , Baoquan SUN , Chunbo SHA , Jinguang LIN , Yonghui GE , Yanliang CHEN , Bin ZHAO , Xiaomin GU , Jian LUO , Chuan CHEN , Xiaofei CAI , Jiajie YE , Jie LI , Fenglai SUN
IPC分类号： C07D311/58 , C07C213/02 , C07C29/143 , C07C35/23
摘要： The present invention provides, a novel method for producing a compound represented by formula (I) and a novel method for producing a compound represented by formula (B) or a salt thereof, which are intermediates in the production of formula (I).
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公开(公告)号：US20210340481A1
公开(公告)日：2021-11-04
申请号：US17267320
申请日：2019-08-09
发明人： Shoji FURUSAKO , Shoji TAKEUCHI
摘要： Provided are an alginate gel fiber for antibody production wherein an antibody-producing cell (for example, an antibody-producing CHO cell) is comprised in a core layer, and an antibody production method using the alginate gel fiber. An antibody production method is thereby additionally provided.
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