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公开(公告)号：US20230340604A1
公开(公告)日：2023-10-26
申请号：US17659946
申请日：2022-04-20
IPC分类号： C12Q1/6886 , A61K31/713 , A61P35/04
CPC分类号： C12Q1/6886 , A61K31/713 , A61P35/04 , C12Q2600/158 , C12Q2600/112
摘要： A method of treating multiple myeloma, comprising administering one or more agents increasing or inhibiting the expression or activity of one or more MM biomarkers to inhibit the progression of multiple myeloma, wherein the one or more MINI biomarkers correspond to gene products from one or more of GABRA3, CTAG2, MAGEA6, SOHLH1, MAGEA1, AFAP1-AS1; CBX2, LINC00484, KIF7, TMSB15A, NEK2, NTRK1, CCND2, NES, PKP2, C1orf226, IFITM1, CDH23, AGRN, DHX58, and LINC02576. A method of diagnosing and treating multiple myeloma in a subject comprises, (a) measuring the level of one or more biomarkers in a sample; (b) comparing the level of the one or more biomarkers to a reference level of the one or more biomarkers; (c) making a diagnosis based on the result of the comparing step; and (d) treating the subject with one or more active agents where the subject is diagnosed with multiple myeloma.
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公开(公告)号：US20220395548A1
公开(公告)日：2022-12-15
申请号：US17660967
申请日：2022-04-27
摘要： The present application relates to a compositions and methods comprising or expressing a hevamine A-related MoMo30 protein from Momordica balsamina. The MoMo30 protein is about 30 kDa in size, is stable after being autoclaved at 120° C. for 30 min, resists proteolytic cleavage by trypsin, exhibits mannose-sensitive binding to HIV gp120, exhibits hemagglutinin and chitinase activity, is capable of activating and stimulating T cell proliferation, is capable of preventing infection by HIV-1 or alleviating symptoms in an HIV-1 infected patients, and comprises an amino acid sequence of SEQ ID NO: 4. The MoMo30 protein and/or a nucleic acid encoding the same may be used in methods for preventing or treating microbial infections by HIV, SARS-CoV-2 and other enveloped viruses, as well as other microorganisms comprising cell surface proteins containing glycan residues, such as mannose.
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公开(公告)号：US20220340845A1
公开(公告)日：2022-10-27
申请号：US17804312
申请日：2022-05-27
摘要： A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition. The resulting cleaning composition may be used for cleaning up pathogens or hazardous materials. The cleaning composition may also functions as a liquefiable dry cleaning powder for public areas in response to bodily fluid incidents. A coating method of a non-toxic bio static film on a high surface area solid is disclosed.
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4.发明申请公开(公告)号：US20220260590A1
公开(公告)日：2022-08-18
申请号：US17662783
申请日：2022-05-10
IPC分类号： G01N33/68 , A61K38/12 , G01N33/74 , A61K31/4025 , A61K45/06 , A61K9/00 , A61K31/40 , A61K31/422 , A61K31/505 , A61K31/506 , C12Q1/6883 , G01N33/569 , G01N33/78
摘要： The present application relates to methods of treating HIV-associated nephropathy (HIVAN) and/or focal segmental glomerulosclerosis (FSGS) using endothelin-1 (ET-1) antagonists. The application further relates to a composition for the treatment of HIVAN and/or FSGS. A kit for detecting the presence of ET-1 or ET-1-associated biomarker in a biological sample is also disclosed.
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公开(公告)号：US20220252600A1
公开(公告)日：2022-08-11
申请号：US17657296
申请日：2022-03-30
发明人： Gale W. NEWMAN , Sam ANYANWU
IPC分类号： G01N33/569 , C12Q1/70 , G01N33/493 , G01N33/68 , G01N33/576
摘要： A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject.
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公开(公告)号：US11360090B2
公开(公告)日：2022-06-14
申请号：US16455807
申请日：2019-06-28
发明人： Gale W. Newman , Sam Anyanwu
IPC分类号： G01N33/53 , C12Q1/70 , A61K39/42 , G01N33/569 , G01N33/493 , G01N33/68 , G01N33/576 , G01N1/40
摘要： A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. Also disclosed are a method for monitoring the course of a hepatitis virus infection or a hepatitis disease condition in a subject and a method for monitoring effectiveness of treatment to a subject with an anti-hepatitis virus agent based on hepatitis virus-associated biomarkers present on exosomes in bodily fluid samples from the subject, as well as a kit for diagnosing hepatitis virus infection and/or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers on exosomes in bodily fluid samples from the subject.
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公开(公告)号：US20220169685A1
公开(公告)日：2022-06-02
申请号：US17669844
申请日：2022-02-11
发明人： Roger P. SIMON , Zhigang XIONG
IPC分类号： C07K14/435 , A61K38/17 , A61K38/16 , A61K31/439 , A61K31/4418 , A61K31/4965 , A61K31/498 , A61K45/06
摘要： A system, including methods and compositions, for treatment of ischemia.
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公开(公告)号：US11345877B2
公开(公告)日：2022-05-31
申请号：US16800596
申请日：2020-02-25
摘要： A method for formulating a cleaning composition contains the step of coating a granular absorbent material with a coating agent to produce a coated absorbent material and mixing the coated absorbent material with a sanitation agent, wherein the coated absorbent material absorbs the sanitation agent to form the cleaning composition. The resulting cleaning composition may be used for cleaning up pathogens or hazardous materials. The cleaning composition may also functions as a liquefiable dry cleaning powder for public areas in response to bodily fluid incidents. A coating method of a non-toxic bio static film on a high surface area solid is disclosed.
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公开(公告)号：US11304991B2
公开(公告)日：2022-04-19
申请号：US16947808
申请日：2020-08-18
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali , Martin N. Shelton
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
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公开(公告)号：US11166999B1
公开(公告)日：2021-11-09
申请号：US16996153
申请日：2020-08-18
摘要： The present application relates to a compositions and methods comprising or expressing a MOMO30 protein derived from Momordica balsamina. The MOMO30 protein is about 30 kDa in size, binds coronavirus S protein, is stable after being autoclaved at 120° C. for 30 min, resists proteolytic cleavage by trypsin, exhibits mannose-sensitive binding to coronavirus spike (S) protein, exhibits hemagglutinin and chitinase activity, is capable of activating and stimulating T cell proliferation, is capable of preventing infection by a coronavirus or alleviating symptoms in coronavirus infected patients and comprises the amino acid sequence of SEQ ID NO: 1. The MOMO30 protein and/or a nucleic acid encoding the same may be used in methods for preventing or treating viral infections by coronaviruses and others.
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