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公开(公告)号：US11304991B2
公开(公告)日：2022-04-19
申请号：US16947808
申请日：2020-08-18
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali , Martin N. Shelton
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
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公开(公告)号：US20190337993A1
公开(公告)日：2019-11-07
申请号：US16519963
申请日：2019-07-23
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/005 , A61K39/39 , C07K14/16 , A61K38/16 , G01N33/543 , A61K9/127 , A61K45/06 , G01N33/566 , C12P21/02
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US20170369533A1
公开(公告)日：2017-12-28
申请号：US15660572
申请日：2017-07-26
发明人： Vincent C. Bond , Michael POWELL , Ming Bo HUANG , Syed ALI
IPC分类号： C07K14/005 , A61K38/16 , A61K39/39 , A61K45/06 , C07K14/16 , G01N33/566 , A61K9/127 , C12P21/02 , G01N33/543 , C12N15/00 , A61K38/00 , A61K39/00
CPC分类号： C07K14/005 , A61K9/127 , A61K38/00 , A61K38/162 , A61K39/39 , A61K45/06 , A61K2039/55555 , C07K14/163 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US11472846B2
公开(公告)日：2022-10-18
申请号：US17068061
申请日：2020-10-12
IPC分类号： A61K38/10 , A61K47/64 , C07K14/00 , C07K19/00 , C07K14/005 , A61K47/60 , C12N7/00 , A61K38/16 , A61K45/06 , A61K38/08
摘要： A method for treating a cancer comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising an anti-cancer agent having at least one secretion modifying region (SMR) peptide from HIV-1 Nef fused to at least one cell-penetrating peptide (CPP) or at least one Clusterin (Clu)-binding peptide (Clu-BP).
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公开(公告)号：US10800817B2
公开(公告)日：2020-10-13
申请号：US16226283
申请日：2018-12-19
IPC分类号： A61K38/08 , A61K35/10 , A61K47/64 , C07K14/005 , A61K47/60 , C12N7/00 , A61K38/16 , A61K45/06 , A61K38/10
摘要： A method for treating a cancer comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising an anti-cancer agent having at least one secretion modifying region (SMR) peptide from HIV-1 Nef fused to at least one cell-penetrating peptide (CPP) or at least one Clusterin (Clu)-binding peptide (Clu-BP).
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公开(公告)号：US11098087B2
公开(公告)日：2021-08-24
申请号：US16458218
申请日：2019-07-01
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/16 , C12P21/02 , G01N33/543 , A61K9/127 , A61K38/16 , A61K39/39 , A61K45/06 , C07K14/005 , G01N33/566 , C12N15/00 , A61K39/00 , A61K38/00
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US10040831B2
公开(公告)日：2018-08-07
申请号：US15383454
申请日：2016-12-19
IPC分类号： A61K38/16 , A61K47/64 , C07K14/00 , C07K19/00 , C07K14/005 , A61K47/48 , A61K45/06 , C12N7/00
CPC分类号： C07K14/005 , A61K38/162 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/641 , C07K2319/035 , C07K2319/70 , C12N7/00 , C12N2740/16022 , C12N2740/16322
摘要： A multipartite peptide that inhibits release of exosomes in a cell, comprising an N-terminal end and a C-terminal end and comprising at least one secretion modifying region (SMR) peptide from HIV-1 Nef and at least one Clusterin (Clu)-binding peptide (Clu-BP). Pharmaceutical compositions comprising these peptides alone or in synergistic combinations with other active agents in methods for treating cancers and/or infectious diseases are further provided herein.
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公开(公告)号：US12077564B2
公开(公告)日：2024-09-03
申请号：US17305749
申请日：2021-07-14
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/16 , A61K9/127 , A61K38/16 , C07K14/005 , A61K38/00 , A61K39/00 , A61K39/39 , A61K45/06 , C12N15/00 , C12P21/02 , G01N33/543 , G01N33/566
CPC分类号： C07K14/163 , A61K9/127 , A61K38/162 , C07K14/005 , A61K38/00 , A61K39/39 , A61K2039/55555 , A61K45/06 , C07K2319/00 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16311 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US11414462B1
公开(公告)日：2022-08-16
申请号：US17380786
申请日：2021-07-20
摘要： The present application relates to methods and compositions and methods for treating viral infections, especially those caused by SARS-CoV-2. In one aspect, a method of treatment comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising a multipartite SARS-CoV-2-inhibiting peptide comprising a secretion modulating region (VI-SMR) peptide from HIV-1 Nef in combination with a cell-penetrating peptide (CPP) domain, a Clusterin (Clu)-binding peptide (Clu-BP) domain, a mitochondrial targeting (Mito-T) peptide domain, an anti-fusogenic (AF) peptide domain, a viral attachment inhibitor (VAI) domain or combination thereof, optionally where the SARS-CoV-2-inhibiting peptide is pegylated and/or modified with one or more hydrophobic domains.
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公开(公告)号：US11180534B1
公开(公告)日：2021-11-23
申请号：US17339197
申请日：2021-06-04
摘要： The present application relates to methods and compositions and methods for treating viral infections, especially those caused by SARS-CoV-2. In one aspect, a method of treatment comprises administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising a multipartite SARS-CoV-2-inhibiting peptide comprising a secretion modulating region (VI-SMR) peptide from HIV-1 Nef in combination with a cell-penetrating peptide (CPP) domain, a Clusterin (Clu)-binding peptide (Clu-BP) domain, a mitochondrial targeting (Mito-T) peptide domain, an anti-fusogenic (AF) peptide domain, a viral attachment inhibitor (VAI) domain or combination thereof, optionally where the SARS-CoV-2-inhibiting peptide is pegylated and/or modified with one or more hydrophobic domains.
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