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公开(公告)号：US20210355172A1
公开(公告)日：2021-11-18
申请号：US17305749
申请日：2021-07-14
发明人： Vincent C. BOND , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/16 , C12P21/02 , G01N33/543 , A61K9/127 , A61K38/16 , A61K39/39 , A61K45/06 , C07K14/005 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US20170209533A1
公开(公告)日：2017-07-27
申请号：US15397359
申请日：2017-01-03
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/49
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
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3.发明申请COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES 有权通过抑制微生物分泌来治疗艾滋病或癌症的组合物和方法公开(公告)号：US20140005117A1
公开(公告)日：2014-01-02
申请号：US14015438
申请日：2013-08-30
发明人： Vincent Craig BOND , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。
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公开(公告)号：US12083158B2
公开(公告)日：2024-09-10
申请号：US16226242
申请日：2018-12-19
IPC分类号： A61K38/00 , A61K38/08 , A61K38/16 , A61K45/06 , A61K47/60 , A61K47/64 , C07K7/06 , C07K14/005 , C12N7/00
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , A61K47/6455 , C07K7/06 , C07K14/005 , C12N7/00 , C07K2319/10 , C12N2740/16032 , C12N2740/16322 , Y02A50/30
摘要： Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.
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公开(公告)号：US11925670B2
公开(公告)日：2024-03-12
申请号：US17805753
申请日：2022-06-07
IPC分类号： A01N63/50 , A01P1/00 , A61K31/352 , A61K33/30 , A61K36/42 , A61K38/47 , A61P31/18 , C12N15/10 , C12N15/82 , C12P19/34
CPC分类号： A61K36/42 , A01N63/50 , A01P1/00 , A61K31/352 , A61K33/30 , A61K38/47 , A61P31/18 , C12N15/1096 , C12N15/8283 , C12P19/34 , C07K2319/01
摘要： In one aspect, nutraceutical compositions, methods of preparation and methods of use comprise a nutraceutical composition comprising an antimicrobial hevamine A-related protein from Momordica balsamina alone or in combination with one or more nutraceutical ingredients. In another aspect, a method of preventing or treating a microbial infection in a plant comprises applying an effective amount of a composition containing the hevamine A-related protein to a whole plant, plant part, or media in which the plant is growing. In a further aspect, the present application provides a transgenic plant stably transformed with a polynucleotide encoding the hevamine A-related protein.
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公开(公告)号：US11098087B2
公开(公告)日：2021-08-24
申请号：US16458218
申请日：2019-07-01
发明人： Vincent C. Bond , Michael Powell , Ming Bo Huang , Syed Ali
IPC分类号： C07K14/16 , C12P21/02 , G01N33/543 , A61K9/127 , A61K38/16 , A61K39/39 , A61K45/06 , C07K14/005 , G01N33/566 , C12N15/00 , A61K39/00 , A61K38/00
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
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公开(公告)号：US20190134151A1
公开(公告)日：2019-05-09
申请号：US16226242
申请日：2018-12-19
摘要： Compositions and methods for reducing the growth of and/or preventing the formation of a microbial biofilm are disclosed. The composition comprises an antimicrobial SMR peptide comprising an HIV-1 SMRwt peptide and a cell penetrating peptide (CPP) domain. In some embodiments, the composition further comprises one or more other antimicrobial peptides (AMPs), antibiotics, matrix-inhibiting compounds, matrix-disaggregating compounds, quorum sensing inhibitors, or a combination thereof. In other embodiments, the compositions are used for impregnating or coating an article and/or material surface with the composition to render it less prone to microbial infections.
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公开(公告)号：US09556224B2
公开(公告)日：2017-01-31
申请号：US14156119
申请日：2014-01-15
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
摘要翻译： 本申请公开了一种使用抗微生物组合物治疗微生物感染的方法，其包含含有至少一种VGFPV基序的抗微生物肽。
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9.发明授权Compositions and methods for treating AIDS or cancer by inhibiting the secretion of microparticles 有权通过抑制微粒分泌来治疗AIDS或癌症的组合物和方法公开(公告)号：US08871708B2
公开(公告)日：2014-10-28
申请号：US14015438
申请日：2013-08-30
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
IPC分类号： A61P31/12 , A61P31/18 , A61P35/00 , A61K39/00 , A61K39/21 , C12N5/22 , C07K7/06 , C07K7/08 , C07K14/005 , A61K38/00
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。
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10.发明申请公开(公告)号：US20130123202A1
公开(公告)日：2013-05-16
申请号：US13693507
申请日：2012-12-04
发明人： Vincent Craig BOND , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
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