公开(公告)号：US10682374B2

公开(公告)日：2020-06-16

申请号：US16126897

申请日：2018-09-10

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US07570286B2

公开(公告)日：2009-08-04

申请号：US11139120

申请日：2005-05-27

Applicant: Hiroyuki Koike ,  Yoichi Sugimoto ,  Ichiro Masaki ,  Izumi Kondo ,  Shugo Kondo

Inventor： Hiroyuki Koike ,  Yoichi Sugimoto ,  Ichiro Masaki ,  Izumi Kondo ,  Shugo Kondo

IPC: H04N9/68 ,  H04N5/225

CPC classification number: G06T5/50 ,  G06T2207/30252

Abstract: A support apparatus for sense of vision includes: a filter device that extracts low frequency components, and respective high frequency components in at least a horizontal direction and a vertical direction from original images obtained by image capture by a plurality of image pickup devices, a frequency component combining device that combines the low frequency components of each of the original images extracted by the filter device to generate a combined low frequency component, and combines the high frequency components of each of the original images extracted by the filter device in at least the horizontal direction and the vertical direction to generate a combined horizontal high frequency component and a combined vertical high frequency component; and a composite image formation device that combines the low combined frequency component, the combined horizontal high frequency component, and the combined vertical high frequency component, generated by the frequency component combining device, to generate a composite image.

Abstract translation: 用于感觉的支持装置包括：滤波器装置，其从通过多个图像拾取装置的图像捕获获得的原始图像至少在水平方向和垂直方向上提取低频分量以及相应的高频分量，频率 组合组合装置，其组合由滤波器装置提取的每个原始图像的低频分量，以产生组合的低频分量，并且将由滤波器装置提取的每个原始图像的高频分量组合在至少水平 方向和垂直方向，以产生组合的水平高频分量和组合的垂直高频分量; 以及合成图像形成装置，其组合由频率分量组合装置生成的低组合频率分量，组合水平高频分量和组合的垂直高频分量，以生成合成图像。