公开(公告)号：US20200330501A1

公开(公告)日：2020-10-22

申请号：US16867291

申请日：2020-05-05

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US10682374B2

公开(公告)日：2020-06-16

申请号：US16126897

申请日：2018-09-10

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US10743750B2

公开(公告)日：2020-08-18

申请号：US15307596

申请日：2015-04-28

Applicant: Massachusetts Institute of Technology

Inventor： Ian W. Hunter ,  Yi Chen ,  Jiahui Liang

IPC: A61B1/00 ,  A61B1/005 ,  A61B1/008 ,  A61B1/018 ,  A61B1/04 ,  A61B1/31 ,  A61B5/06 ,  A61B6/12 ,  A61B6/00 ,  A61B34/20 ,  A61B34/30 ,  A61B90/00

Abstract: Robotic endoscopes have the potential to help endoscopists position tools during procedures, to propel the endoscope to the desired position, to automate functions and to prevent perforations during procedures. Modular architecture for a continuum robotic endoscope with multiple bending segments along the length of the endoscope. Each of the segments is modular, containing a set of actuation motors that drive short cables in the continuum segments.

公开(公告)号：US10463276B2

公开(公告)日：2019-11-05

申请号：US15342718

申请日：2016-11-03

Applicant: Massachusetts Institute of Technology

Inventor： Ian W. Hunter ,  Yi Chen

IPC: A61B5/00 ,  A61B5/103 ,  A01G7/00 ,  G01N3/24 ,  G01N3/40 ,  A61B9/00

Abstract: A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. The probe can be coupled to the tissue surface. The device can include a reference surface configured to contact the tissue surface. The probe may include a set of interchangeable heads, the set including a head for lateral movement of the probe and a head for perpendicular movement of the probe. The perturbation can include extension of the tissue with the probe or sliding the probe across the tissue surface and may also include indentation of the tissue with the probe. In some embodiments, the actuator includes a Lorentz force linear actuator. The mechanical property may be determined using non-linear stochastic system identification. The mechanical property may be indicative of, for example, tissue compliance and tissue elasticity. The device can further include a handle for manual application of the probe to the surface of the tissue and may include an accelerometer detecting an orientation of the probe. The device can be used to test skin tissue of an animal, plant tissue, such as fruit and vegetables, or any other biological tissue.

公开(公告)号：US20190076462A1

公开(公告)日：2019-03-14

申请号：US16126897

申请日：2018-09-10

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  C07C237/08 ,  G01N33/15 ,  C07C271/22 ,  C07C237/12 ,  C12Q1/02 ,  C07C229/24 ,  C07C279/14 ,  C07D209/20 ,  C07D207/16 ,  C07D487/06 ,  C07C229/26 ,  C07C229/22 ,  C07C229/12 ,  C07D241/08 ,  C07D403/06 ,  C07D233/64 ,  C12N15/88 ,  C12N15/87 ,  A61K47/22 ,  A61K31/711 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C07C323/58 ,  C07D209/24 ,  C07C229/36

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US20230124955A1

公开(公告)日：2023-04-20

申请号：US17893918

申请日：2022-08-23

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US20170165290A1

公开(公告)日：2017-06-15

申请号：US15340082

申请日：2016-11-01

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  A61K47/22 ,  C07D241/08 ,  A61K31/711

CPC classification number: A61K31/7105 ,  A61K31/711 ,  A61K47/22 ,  A61K2121/00 ,  C07C229/12 ,  C07C229/22 ,  C07C229/24 ,  C07C229/26 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C07C271/22 ,  C07C279/14 ,  C07C323/58 ,  C07D207/16 ,  C07D209/20 ,  C07D209/24 ,  C07D233/64 ,  C07D241/08 ,  C07D265/32 ,  C07D403/06 ,  C07D413/06 ,  C07D487/04 ,  C07D487/06 ,  C12N15/87 ,  C12N15/88 ,  C12Q1/025 ,  G01N33/15

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US09517030B2

公开(公告)日：2016-12-13

申请号：US14310744

申请日：2014-06-20

Applicant: Massachusetts Institute of Technology

Inventor： Ian W. Hunter ,  Yi Chen

IPC: A61B5/00 ,  A01G7/00 ,  G01N3/24 ,  G01N3/40 ,  A61B9/00

CPC classification number: A61B5/103 ,  A01G7/00 ,  A61B5/0048 ,  A61B5/0053 ,  A61B5/0055 ,  A61B5/0057 ,  A61B5/442 ,  A61B5/6824 ,  A61B9/00 ,  G01N3/24 ,  G01N3/40 ,  G01N2203/0069 ,  G01N2203/0218 ,  G01N2203/0246 ,  G01N2203/0278

Abstract: A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. The probe can be coupled to the tissue surface. The device can include a reference surface configured to contact the tissue surface. The probe may include a set of interchangeable heads, the set including a head for lateral movement of the probe and a head for perpendicular movement of the probe. The perturbation can include extension of the tissue with the probe or sliding the probe across the tissue surface and may also include indentation of the tissue with the probe. In some embodiments, the actuator includes a Lorentz force linear actuator. The mechanical property may be determined using non-linear stochastic system identification. The mechanical property may be indicative of, for example, tissue compliance and tissue elasticity. The device can further include a handle for manual application of the probe to the surface of the tissue and may include an accelerometer detecting an orientation of the probe. The device can be used to test skin tissue of an animal, plant tissue, such as fruit and vegetables, or any other biological tissue.

Abstract translation: 用于测量组织的机械特性的装置包括配置成相对于组织表面移动来干扰组织的探针，耦合到探针以移动探针的致动器，被配置成测量组织的响应的检测器 扰动和耦合到致动器和检测器的控制器。 控制器使用随机序列驱动致动器，并使用从检测器接收的测量响应来确定组织的机械特性。 探针可以耦合到组织表面。 该装置可以包括构造成接触组织表面的参考表面。 探针可以包括一组可互换的头部，该组件包括用于探针的横向运动的头部和用于探针的垂直运动的头部。 扰动可以包括用探针延伸组织或者将探针滑过组织表面，还可以包括用探针的组织​​的凹陷。 在一些实施例中，致动器包括洛伦兹力线性致动器。 可以使用非线性随机系统识别来确定机械特性。 机械性能可以指示例如组织依从性和组织弹性。 该装置还可以包括用于将探针手动施加到组织表面的手柄，并且可以包括检测探针取向的加速度计。 该装置可用于测试动物，植物组织如水果和蔬菜或任何其他生物组织的皮肤组织。

公开(公告)号：US20130158021A1

公开(公告)日：2013-06-20

申请号：US13662002

申请日：2012-10-26

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vagas ,  Akinleye Alabi ,  Yunlong Zhang

IPC: C07C323/58 ,  C12Q1/02 ,  C07D241/08 ,  C12N15/87 ,  C07D487/04 ,  C07D413/06 ,  C07C279/14 ,  C07C229/12 ,  C07C229/24 ,  C07D209/24 ,  C07D233/64 ,  C07D265/32 ,  G01N33/15 ,  C07D403/06

CPC classification number: A61K31/7105 ,  A61K31/711 ,  A61K47/22 ,  A61K2121/00 ,  C07C229/12 ,  C07C229/22 ,  C07C229/24 ,  C07C229/26 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C07C271/22 ,  C07C279/14 ,  C07C323/58 ,  C07D207/16 ,  C07D209/20 ,  C07D209/24 ,  C07D233/64 ,  C07D241/08 ,  C07D265/32 ,  C07D403/06 ,  C07D413/06 ,  C07D487/04 ,  C07D487/06 ,  C12N15/87 ,  C12N15/88 ,  C12Q1/025 ,  G01N33/15

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

Abstract translation: 本文描述的是化合物和组合物，在某些实施方案中，通过将各种基团如亲脂基团与氨基酸，线性或环状肽，线性或环状多肽或其结构异构体的氨基或酰胺基团缀合， ，以提供本文共同称为“应用”的本发明化合物。 这样的APPL被认为对于各种应用是有用的，例如改进的核苷酸递送。 示例性应用包括但不限于本文所述的式（I），（II），（III），（IV），（V）和（VI）及其盐的化合物：其中m，n ，p，R'，R 1，R 2，R 3，R 4，R 5，R 8，Z，W，Y和Z如本文所定义。

公开(公告)号：US11458158B2

公开(公告)日：2022-10-04

申请号：US16867291

申请日：2020-05-05

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.