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公开(公告)号：US11999874B2
公开(公告)日：2024-06-04
申请号：US16847583
申请日：2020-04-13
CPC分类号： C09F7/06 , C08G63/06 , C08G63/48 , C08L91/005
摘要： Provided are a thermoplastic polymer and a method of forming a thermoplastic polymer. The thermoplastic polymer includes a thermoplastic polymer including one or more fatty acids derived from a plant-based oil. In some embodiments, the thermoplastic polymer includes a structure according to the formula (C18HxO2)y, wherein each x is individually selected from the group consisting of 32 and 33, and wherein y is between 1 and 300. The method of forming a thermoplastic polymer including epoxidizing a plant-based oil to form an epoxidized plant-based oil; saponifying the epoxidized plant-based oil to separate the fatty acids from the glycerol; and then polymerizing the separated fatty acids to form the thermoplastic polymer.
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公开(公告)号：US11918727B2
公开(公告)日：2024-03-05
申请号：US17328049
申请日：2021-05-24
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education , Carnegie Mellon University , Mississippi State University
发明人： Shalv Madhani , Brian Joseph Frankowski , William J. Federspiel , Gregory Burgreen , James F. Antaki
IPC分类号： A61M1/36 , A61M1/16 , A61M60/113 , A61M60/232 , A61M60/38 , A61M60/419 , A61M60/422 , A61M60/82 , A61M60/824 , A61M60/825
CPC分类号： A61M1/3667 , A61M1/1625 , A61M1/1698 , A61M1/3666 , A61M60/113 , A61M60/232 , A61M60/38 , A61M60/419 , A61M60/422 , A61M60/82 , A61M60/824 , A61M60/825 , A61M2205/7536
摘要： An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment. The system further includes a fiber bundle with a plurality of hollow gas permeable fibers extending generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet.
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公开(公告)号：US20230375448A1
公开(公告)日：2023-11-23
申请号：US18364726
申请日：2023-08-03
CPC分类号： G01N3/062 , G01N3/30 , G01N2203/0658 , G01N2203/0075
摘要： The present disclosure relates to compact waveguides. One example includes a primary bar, and an impedance-matched series of secondary bars with a number of turns, where turns provide at least one of: a turn that is perpendicular to an immediately preceding turn, and an increase in length of a subset of secondary bars for the turn.
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公开(公告)号：US20220225961A1
公开(公告)日：2022-07-21
申请号：US17716352
申请日：2022-04-08
发明人： ALI BORAZJANI , BENJAMIN C. WEED , JUN LIAO
摘要： An imaging probe adapter for measuring the properties of a lumen like the vaginal canal, the rectum, or anal sphincter. The device has an adapter body with a proximal end and a distal end. The distal end of the adapter body may be formed into an insertion tip capable of easy insertion into the appropriate lumenal structure. An inflatable pressure chamber covers the distal end of the adapter body. A baseplate formed on the proximal end of the adapter body incorporates fluid channels for inflating the pressure chamber and a probe channel that receives an ultrasound probe or other suitable imaging probe. The device is used to measure and model lumenal biomechanical properties such as stiffness, compliance, elastic versus viscous contributions to overall stiffness, and total displacement.
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公开(公告)号：US11285199B2
公开(公告)日：2022-03-29
申请号：US16972887
申请日：2018-12-13
发明人： Dong Chan Moon , Suk Kyung Lim , Keum Chan Jang , Suk Chan Jung , Hee Soo Lee , Bang Hun Hyun , Hyang Mi Nam , Heui Jin Kim , Keun Seok Seo
IPC分类号： A61K39/085 , C07K14/31 , A61K39/00
摘要： The present invention relates to a vaccine composition comprising a Staphylococcus aureus attenuated enterotoxin protein and cytotoxin protein, and more particularly to a Staphylococcus aureus enterotoxin protein, a Staphylococcus aureus cytotoxin protein, a vaccine composition for prevention of bovine mastitis, comprising the Staphylococcus aureus enterotoxin protein and Staphylococcus aureus cytotoxin protein and a method for preventing bovine mastitis comprising administering the vaccine composition to a bovine. The Staphylococcus aureus enterotoxin protein, the Staphylococcus aureus cytotoxin protein according to the present invention, and the vaccine composition comprising the proteins as an antigen can be used so that even vaccines comprising several antigens rather than all kinds of antigens show the excellent effects of prevention and treatment of bovine mastitis against all kinds of Staphylococcus aureus enterotoxin and cytotoxin having high incidence in Korea, thereby being more economically used for industrial purposes. Further, the vaccine composition for prevention of bovine mastitis, comprising the Staphylococcus aureus enterotoxin protein and Staphylococcus aureus cytotoxin protein according to the present invention has an excellent safety and bovine mastitis prevention and treatment effect even in the high CFU Staphylococcus aureus challenge test so that the composition can be variously utilized in Staphylococcus aureus vaccine and prevention related fields in future.
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公开(公告)号：US20210077706A1
公开(公告)日：2021-03-18
申请号：US16961440
申请日：2019-01-15
申请人： University of Pittsburgh - Of theCommonwealth System of Higher Education , Mississippi State University
发明人： William J. Federspiel , Shalv Madhani , Ryan A. Orizondo , Peter Drew Wearden , Brian Joseph Frankowski , Alexandra May , Gregory Burgreen
摘要： A system for lung assist includes a plurality of fiber bundle sections which includes a fiber bundle housing defining a fiber bundle compartment with a fiber bundle positioned within. The fiber bundle includes a plurality of hollow gas permeable fibers. The fiber bundle housing further includes a gas inlet in fluid connection with the fiber bundle housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers, and a blood outlet in fluid connection with a first end of the fiber bundle. The system further includes a base section including a housing including a pressurizing compartment, a pressurizing mechanism within the pressurizing compartment, a blood inlet in fluid connection with the pressurizing compartment and a conduit.
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公开(公告)号：US10850266B2
公开(公告)日：2020-12-01
申请号：US15714238
申请日：2017-09-25
发明人： Mark G. White , Shetian Liu
IPC分类号： B01J29/48 , B01J29/78 , B01J29/08 , B01J23/28 , C10L3/12 , C10L1/08 , C10G2/00 , B01J37/02 , B01J29/16 , B01J29/076 , B01J29/26 , B01J29/03
摘要： The present invention provides a novel process and system in which a mixture of carbon monoxide and hydrogen synthesis gas, or syngas, is converted into hydrocarbon mixtures composed of high quality gasoline components, aromatic compounds, and lower molecular weight gaseous olefins in one reactor or step. The invention utilizes a novel molybdenum-zeolite catalyst in high pressure hydrogen for conversion, as well as a novel rhenium-zeolite catalyst in place of the molybdenum-zeolite catalyst, and provides for use of the novel catalysts in the process and system of the invention.
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公开(公告)号：US10265374B2
公开(公告)日：2019-04-23
申请号：US15510801
申请日：2015-09-14
发明人： James L. Smith , Stephen Pruett , Frank Austin , Shien Lu , Ravichandran Akshaya , Steven Laihing
摘要： Disclosed are occidiofungin formulations and uses thereof for the treatment of proliferative disorders, such as cancer. Methods of producing the disclosed occidiofungin formulations are also provided. Further, methods of treating a subject with the formulations are provided. In some embodiments, the formulations include occidiofungin and one or more cyclodextrins. The formulations may optionally further comprise an additional chemotherapeutic agent for treating the proliferative disease, lipid vesicles, and/or aqueous solvents (including pharmaceutically acceptable buffers and/or exceipients).
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公开(公告)号：US20190017045A1
公开(公告)日：2019-01-17
申请号：US16034089
申请日：2018-07-12
申请人： Keun Seok Seo , Joo Youn Park
发明人： Keun Seok Seo , Joo Youn Park
IPC分类号： C12N15/11 , C12N9/22 , A61K9/00 , A01N63/02 , C12N15/66 , C12N15/74 , A61K38/46 , A61K31/7088
摘要： A method and composition for the production of sequence specific antimicrobials capable of overcoming inefficient delivery, narrow host range, and potential transfer of virulence genes by generalized transduction of phage-based delivery systems by integrating CRISPR/Cas9 system in the phage genome, removing major virulence genes from host chromosome, and expanding host specificity of phage by complementing tail fiber protein which significantly improves the efficacy and safety of CRISPR/Cas9 antimicrobials as alternative therapeutics. The method and composition provide an efficacious and safe CRISPR/Cas9 antimicrobial, broadly applicable to MRSA.
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公开(公告)号：USD831895S1
公开(公告)日：2018-10-23
申请号：US29592988
申请日：2017-02-03
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