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1.发明申请IMMUNOGENIC COMPOSITIONS CONTAINING ESCHERICHIA COLI H7 FLAGELLA AND METHODS OF USE THEREOF 审中-公开含有ESCHERICHIA COLI H7 FLAGELLA的免疫组合物及其使用方法公开(公告)号：US20160074493A1
公开(公告)日：2016-03-17
申请号：US14949291
申请日：2015-11-23
申请人： The University Court of the University of Edinburgh , Moredun Research Institute , The Scottish Agricultural College
发明人： David GALLY , Tom Nathan MCNEILLY , David George Emslie SMITH , Chris LOW , Arvind Kumar MAHAJAN , Stuart W. NAYLOR
IPC分类号： A61K39/108 , C07K14/245 , A61K39/39
CPC分类号： A61K39/0258 , A61K39/00 , A61K39/39 , A61K2039/552 , A61K2039/55555 , A61K2039/55577 , A61K2039/57 , C07K14/245 , C07K16/1232 , C07K2319/00 , Y02A50/474
摘要： Immunogenic compositions containing Escherichia coli 0157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli O157:H7 flagella will result in prevention of colonization by Escherichia coli O157:H7 in the animal or a reduction in the amount of Escherichia coli O157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli 0157:H7 to cells within the animal.
摘要翻译： 公开了含有包含融合蛋白的大肠杆菌0157：H7鞭毛的免疫原性组合物和使用免疫原性组合物的方法。 在动物中诱导大肠杆菌O157：H7鞭毛的免疫应答将导致预防动物中大肠杆菌O157：H7的定居，或减少感染动物的大肠杆菌O157：H7的量。 免疫组合物将预防或减少大肠杆菌0157：H7与动物内细胞的连接。
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公开(公告)号：US07128916B2
公开(公告)日：2006-10-31
申请号：US10473664
申请日：2002-03-25
申请人： John Bernard March
发明人： John Bernard March
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57
摘要： The present invention relates to vaccines comprising a bacteriophage which has been engineered to express an immunogenic protein/peptide and wherein the surface of the bacteriophage has not been modified to contain proteins/peptides designed to target the phage to receptors on the surface of specific cell types.
摘要翻译： 本发明涉及包含已经被工程化以表达免疫原性蛋白质/肽的噬菌体的疫苗，并且其中噬菌体的表面未被修饰以包含被设计为将噬菌体靶向特定细胞类型的表面上的受体的蛋白质/肽 。
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3.发明授权公开(公告)号：US10363297B2
公开(公告)日：2019-07-30
申请号：US14949291
申请日：2015-11-23
发明人： David Gally , Tom Nathan McNeilly , David George Emslie Smith , Chris Low , Arvind Kumar Mahajan , Stuart W. Naylor
IPC分类号： A61K39/00 , A61K39/108 , C07K14/245 , C07K16/12 , A61K39/39
摘要： Immunogenic compositions containing Escherichia coli 0157:H7 flagella including fusion proteins and methods using the immunogenic compositions are disclosed. Inducing an immune response in an animal to Escherichia coli O157:H7 flagella will result in prevention of colonization by Escherichia coli O157:H7 in the animal or a reduction in the amount of Escherichia coli O157:H7 infecting the animal. The immune composition will prevent or reduce the attachment of Escherichia coli 0157:H7 to cells within the animal.
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公开(公告)号：US09239330B2
公开(公告)日：2016-01-19
申请号：US14193380
申请日：2014-02-28
IPC分类号： G01N33/569 , G01N33/53
CPC分类号： G01N33/569 , G01N33/5308 , G01N2333/4353
摘要： The present invention provides a method of diagnosing a cyathostomin infection, said method comprising the step of identifying a level of anti-cyathostomin larval antigen antibodies in a sample, wherein a level of anti-cyathostomin larval antigen antibodies is indicative of a cyathostomin infection.
摘要翻译： 本发明提供了一种诊断细胞宿主感染的方法，所述方法包括鉴定样品中抗细胞死亡宿主抗原抗体水平的步骤，其中抗细胞死亡宿主抗原抗体水平表示细胞宿主病毒感染。
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公开(公告)号：US20120082992A1
公开(公告)日：2012-04-05
申请号：US13260935
申请日：2010-03-31
IPC分类号： C12Q1/68 , C12N1/21 , G01N33/569 , C12N15/70 , C07K14/435 , C12N15/12
CPC分类号： G01N33/569 , G01N33/5308 , G01N2333/4353
摘要： The present invention provides a method of diagnosing a cyathostomin infection, said method comprising the step of identifying a level of anti-cyathostomin larval antigen antibodies in a sample, wherein a level of anti-cyathostomin larval antigen antibodies is indicative of a cyathostomin infection.
摘要翻译： 本发明提供了一种诊断细胞宿主感染的方法，所述方法包括鉴定样品中抗细胞死亡宿主抗原抗体水平的步骤，其中抗细胞死亡宿主抗原抗体水平表示细胞宿主病毒感染。
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公开(公告)号：US09717780B2
公开(公告)日：2017-08-01
申请号：US14376234
申请日：2013-02-04
IPC分类号： A61K39/00 , A61K39/38 , A61K39/002 , C07K14/435 , C07K16/18
CPC分类号： A61K39/0003 , A61K2039/552 , C07K14/4354 , C07K16/18
摘要： The present invention is based upon the identification of a number of antigens derived from species of the genus Teladorsagia, which can be used to raise immune responses in animals—particularly those animals susceptible or predisposed to infection by (or with) one or more Teladorsagia species. The antigens may be exploited to provide compositions and vaccines for raising protective immune responses in animals—the protective immune responses serving to reduce, prevent, treat or eliminate Teladorsagia infections/infestations.
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公开(公告)号：US20140242619A1
公开(公告)日：2014-08-28
申请号：US14193380
申请日：2014-02-28
IPC分类号： G01N33/569
CPC分类号： G01N33/569 , G01N33/5308 , G01N2333/4353
摘要： The present invention provides a method of diagnosing a cyathostomin infection, said method comprising the step of identifying a level of anti-cyathostomin larval antigen antibodies in a sample, wherein a level of anti-cyathostomin larval antigen antibodies is indicative of a cyathostomin infection.
摘要翻译： 本发明提供了一种诊断细胞宿主感染的方法，所述方法包括鉴定样品中抗细胞死亡宿主抗原抗体水平的步骤，其中抗细胞死亡宿主抗原抗体水平表示细胞宿主病毒感染。
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公开(公告)号：US08663939B2
公开(公告)日：2014-03-04
申请号：US13260935
申请日：2010-03-31
IPC分类号： G01N33/569 , G01N33/535
CPC分类号： G01N33/569 , G01N33/5308 , G01N2333/4353
摘要： The present invention provides a method of diagnosing a cyathostomin infection, said method comprising the step of identifying a level of anti-cyathostomin larval antigen antibodies in a sample, wherein a level of anti-cyathostomin larval antigen antibodies is indicative of a cyathostomin infection.
摘要翻译： 本发明提供了一种诊断细胞宿主感染的方法，所述方法包括鉴定样品中抗细胞死亡宿主抗原抗体水平的步骤，其中抗细胞死亡宿主抗原抗体水平表示细胞宿主病毒感染。
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公开(公告)号：US20230120068A1
公开(公告)日：2023-04-20
申请号：US17906220
申请日：2021-03-12
摘要： A device for detecting a substance in a solution, wherein the device comprises: a substrate comprising silicon; a first electrode for use as a working electrode in an electrochemical cell and coupled to the substrate; and Ohmic contacts coupled to the substrate and configured to pass a current through the substrate when connected to a power source.
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公开(公告)号：US20220228169A1
公开(公告)日：2022-07-21
申请号：US17608031
申请日：2020-05-01
摘要： The disclosure provides a plasmid and a lentiviral vector system which may be used to generate lentiviral vector particles for use in transduction. The disclosed vector system and/or plasmid improves the transduction efficiency of the generated lentiviral vector particles and may be exploited to provide compositions for raising immune responses in animals and as vaccines.
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