公开(公告)号：US11897947B1

公开(公告)日：2024-02-13

申请号：US18227030

申请日：2023-07-27

申请人： KING FAISAL UNIVERSITY

发明人： Sabry Mohamed Bahy El-Bahr ,  El Awad M. El Hassan ,  Mohammad H. Al-Omran

IPC分类号： C07K16/18 ,  G01N33/569

CPC分类号： C07K16/18 ,  G01N33/56966 ,  G01N2333/4353 ,  G01N2469/10

摘要： An ELISA for the diagnosis of Haemonchus longistipes infection in camels is provided. The ELISA for the diagnosis of Haemonchus longistipes infection in camels includes antibodies raised against a 76 kDa protein isolated from Haemonchus longistipes. The resulting antibodies may be used in assays to detect Haemonchus longistipes infected camels. The assays may be any kind of enzyme-linked immunosorbent assay, or “ELISA”, known to those of skill in the art. The assay using the antibodies raised against a 76 kDa protein isolated from Haemonchus longistipes infected camels may be capable of detecting pre-patent Haemonchus longistipes infection.

公开(公告)号：US20170343544A1

公开(公告)日：2017-11-30

申请号：US15652527

申请日：2017-07-18

申请人： IDEXX Laboratories, Inc. ,  Monsanto Company

发明人： David Allen ELSEMORE ,  Jinming GENG ,  Laurie A. FLYNN ,  Michael CRAWFORD

IPC分类号： G01N33/569 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/56966 ,  G01N33/5308 ,  G01N33/6893 ,  G01N2333/43526 ,  G01N2333/4353 ,  G01N2469/10

摘要： Methods, devices, kits and compositions for detecting the presence or absence of one or more helminthic coproantigens in a sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm, whipworm and/or hookworm in a fecal sample from a mammal and may also be able to distinguish between one or more helminth infections. Confirmation of the presence or absence of roundworm, whipworm and/or hookworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.

公开(公告)号：US09239330B2

公开(公告)日：2016-01-19

申请号：US14193380

申请日：2014-02-28

申请人： MOREDUN RESEARCH INSTITUTE

发明人： Jacqui Matthews ,  Jane Hodgkinson ,  Christopher Proudman

IPC分类号： G01N33/569 ,  G01N33/53

CPC分类号： G01N33/569 ,  G01N33/5308 ,  G01N2333/4353

摘要： The present invention provides a method of diagnosing a cyathostomin infection, said method comprising the step of identifying a level of anti-cyathostomin larval antigen antibodies in a sample, wherein a level of anti-cyathostomin larval antigen antibodies is indicative of a cyathostomin infection.

摘要翻译： 本发明提供了一种诊断细胞宿主感染的方法，所述方法包括鉴定样品中抗细胞死亡宿主抗原抗体水平的步骤，其中抗细胞死亡宿主抗原抗体水平表示细胞宿主病毒感染。

公开(公告)号：US09068993B2

公开(公告)日：2015-06-30

申请号：US13882850

申请日：2011-10-31

申请人： Thomas B. Nutman ,  Doran Fink ,  Joseph Kubofcik ,  Peter D. Burbelo

发明人： Thomas B. Nutman ,  Doran Fink ,  Joseph Kubofcik ,  Peter D. Burbelo

IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/569 ,  G01N33/68 ,  C07K14/435

CPC分类号： G01N33/6893 ,  C07K14/4354 ,  G01N33/569 ,  G01N2333/4353

摘要： The polynucleotide encoding the antigen Wb123 from the filarial nematode Wuchereria bancrofti, the major causative organism of lymphatic filariasis is provided, along with the polypeptide encoded by the polynucleotide. Methods for making the WM23 antigen, recombinant vectors encoding the Wb123 polynucleotide, and methods of detection of the Wb123 antigen through luciferase immunoprecipitation, ELISA and other detection systems are also provided.

摘要翻译： 提供编码来自丝状线虫Wuchereria bancrofti的抗原Wb123的多核苷酸，其是淋巴丝虫病的主要致病生物，以及由多核苷酸编码的多肽。 还提供了制备WM23抗原的方法，编码Wb123多核苷酸的重组载体，以及通过荧光素酶免疫沉淀，ELISA和其它检测系统检测Wb123抗原的方法。

公开(公告)号：US20120082992A1

公开(公告)日：2012-04-05

申请号：US13260935

申请日：2010-03-31

申请人： Jacqui Matthews ,  Jane Hodgkinson ,  Christopher Proudman

发明人： Jacqui Matthews ,  Jane Hodgkinson ,  Christopher Proudman

IPC分类号： C12Q1/68 ,  C12N1/21 ,  G01N33/569 ,  C12N15/70 ,  C07K14/435 ,  C12N15/12

CPC分类号： G01N33/569 ,  G01N33/5308 ,  G01N2333/4353

摘要： The present invention provides a method of diagnosing a cyathostomin infection, said method comprising the step of identifying a level of anti-cyathostomin larval antigen antibodies in a sample, wherein a level of anti-cyathostomin larval antigen antibodies is indicative of a cyathostomin infection.

摘要翻译： 本发明提供了一种诊断细胞宿主感染的方法，所述方法包括鉴定样品中抗细胞死亡宿主抗原抗体水平的步骤，其中抗细胞死亡宿主抗原抗体水平表示细胞宿主病毒感染。

公开(公告)号：US08058502B2

公开(公告)日：2011-11-15

申请号：US12228707

申请日：2008-08-15

申请人： Andrea C. Carrano ,  Andrew Dillin ,  Tony Hunter

发明人： Andrea C. Carrano ,  Andrew Dillin ,  Tony Hunter

IPC分类号： G01N33/00 ,  A01K67/00 ,  C12P21/06 ,  C12N5/00 ,  C07H21/04 ,  C07K1/00

CPC分类号： G01N33/5085 ,  A01K67/0333 ,  A01K2207/05 ,  A01K2217/052 ,  A01K2217/054 ,  A01K2227/703 ,  A01K2267/03 ,  C07K2319/60 ,  C12N9/93 ,  G01N2333/4353 ,  G01N2500/00

摘要： Ubiquitin ligase wwp-1 and ubiquitin conjugating enzyme ubc-18 are identified in nematodes as mediators of dietary restriction induced longevity and therefore as targets for modulation of lifespan in animals. Methods of screening for compounds that modulate longevity by assaying wwp-1 ubiquitination pathway parameters are provided, as are related systems. In addition, methods of using wwp-1 and/or ubc-18 to modulate longevity or delay onset of age-related diseases are described.

摘要翻译： 泛素连接酶wwp-1和泛素结合酶ubc-18在线虫中被鉴定为膳食限制性诱导的寿命的介质，因此作为调节动物寿命的目标。 提供了通过测定wwp-1泛素化途径参数来调节长寿的化合物的方法，以及相关系统。 此外，描述了使用wwp-1和/或ubc-18来调节年龄相关疾病的寿命或延迟发作的方法。

公开(公告)号：US08048637B2

公开(公告)日：2011-11-01

申请号：US12666027

申请日：2007-06-29

申请人： Patrik Buholzer ,  Alex Raber ,  Paul Price ,  Daniel Zwald ,  Weldy Bonilla Pinschewer ,  Roger Marti ,  Jurg Weidmann ,  Christoph Stamm

发明人： Patrik Buholzer ,  Alex Raber ,  Paul Price ,  Daniel Zwald ,  Weldy Bonilla Pinschewer ,  Roger Marti ,  Jurg Weidmann ,  Christoph Stamm

IPC分类号： G01N33/53 ,  G01N33/532 ,  G01N33/531 ,  G01N33/533 ,  A61K38/00

CPC分类号： G01N33/5308 ,  C07K14/4354 ,  G01N33/569 ,  G01N33/6854 ,  G01N2333/4353

摘要： A diagnostic composition to detect antibodies in a sample obtained from an animal or human being infected by Trichinella, comprising at least one peptide containing a series of amino acids that form a continuous or discontinuous epitope recognized by sera from pigs infected with Trichinella.

摘要翻译： 一种用于检测从被旋毛虫感染的动物或人获得的样品中的抗体的诊断组合物，其包含至少一种含有一系列氨基酸的肽，所述氨基酸形成由感染旋毛虫的猪的血清识别的连续或不连续表位。

公开(公告)号：US20100235930A1

公开(公告)日：2010-09-16

申请号：US12664349

申请日：2008-06-12

申请人： Richard John Shaw ,  Merie Christine Cannon ,  Sarah Margaret Rosanowski ,  Mary Wheeler ,  Christopher Anthony Morris

发明人： Richard John Shaw ,  Merie Christine Cannon ,  Sarah Margaret Rosanowski ,  Mary Wheeler ,  Christopher Anthony Morris

IPC分类号： A01K67/033 ,  G01N33/68 ,  G01N33/53 ,  B01L3/00

CPC分类号： A01K67/02 ,  A61K39/00 ,  A61K2039/552 ,  C07K16/18 ,  G01N33/5308 ,  G01N33/6893 ,  G01N2333/4353 ,  G01N2469/20

摘要： The present invention is directed to a method of selecting animals that are genetically resistant to one or more intestinal parasite infections by testing mucus samples for the presence of an antibody against one or more of said intestinal parasites and segregation and selecting the animals that test positive. The animals that test negative are less parasite resistant and can be subjected to parasite management regimes.

摘要翻译： 本发明涉及一种选择对一种或多种肠道寄生虫感染具有遗传抗性的动物的方法，该动物通过检测粘液样品中是否存在抗一种或多种所述肠寄生虫和分离的抗体并选择测试阳性的动物。 测试阴性的动物抗寄生虫抗性较小，可以进行寄生虫管理方案。

公开(公告)号：US20100190182A1

公开(公告)日：2010-07-29

申请号：US12666027

申请日：2007-06-29

申请人： Patrik Buholzer ,  Alex Raber ,  Paul Price ,  Daniel Zwald ,  Weldy Bonilla Pinschewer ,  Roger Marti ,  Jurg Weidmann ,  Christoph Stamm

发明人： Patrik Buholzer ,  Alex Raber ,  Paul Price ,  Daniel Zwald ,  Weldy Bonilla Pinschewer ,  Roger Marti ,  Jurg Weidmann ,  Christoph Stamm

IPC分类号： G01N33/53 ,  C07K2/00

CPC分类号： G01N33/5308 ,  C07K14/4354 ,  G01N33/569 ,  G01N33/6854 ,  G01N2333/4353

摘要： A diagnostic composition to detect antibodies in a sample obtained from an animal or human being infected by Trichinella, comprising at least one peptide containing a series of amino acids that form a continuous or discontinuous epitope recognized by sera from pigs infected with Trichinella.

摘要翻译： 一种用于检测从被旋毛虫感染的动物或人获得的样品中的抗体的诊断组合物，其包含至少一种含有一系列氨基酸的肽，所述氨基酸形成由感染旋毛虫的猪的血清识别的连续或不连续表位。

公开(公告)号：US20080227193A1

公开(公告)日：2008-09-18

申请号：US12061072

申请日：2008-04-02

申请人： Andrew P. Kloek ,  Deryck J. Williams ,  Merry B. McLaird ,  John D. Bradley ,  Jennifer A. Davila-Aponte ,  Siqun Xu ,  Anita M. Frevert

发明人： Andrew P. Kloek ,  Deryck J. Williams ,  Merry B. McLaird ,  John D. Bradley ,  Jennifer A. Davila-Aponte ,  Siqun Xu ,  Anita M. Frevert

IPC分类号： C12N5/06 ,  C12N15/11 ,  C12N15/00

CPC分类号： C12N9/0083 ,  C12N15/8247 ,  C12N15/8285 ,  G01N33/573 ,  G01N2333/4353 ,  Y02A40/164

摘要： Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid desaturase-like polypeptides, as well as methods for antibody production.

摘要翻译： 描述了编码脂肪酸去饱和酶多肽的线虫的核酸分子。 还提供了脂肪酸去饱和酶样多肽序列，以及用于产生脂肪酸去饱和酶样核苷酸和多肽的载体，宿主细胞和重组方法。 还描述了用于鉴定脂肪酸去饱和酶样多肽的抑制剂和/或激活剂的筛选方法以及用于抗体生产的方法。