-
公开(公告)号：US20210106579A1
公开(公告)日：2021-04-15
申请号：US17055545
申请日：2019-05-17
申请人： Neuralstem, Inc.
发明人： Karl K. JOHE
IPC分类号： A61K31/496 , A61P25/28
摘要： Cognitive and/or motor deficiencies associated with Alzheimer's are treated using 2-amino substituted nicotinamides on their pharmaceutically acceptable salts.
-
公开(公告)号：US20180071267A1
公开(公告)日：2018-03-15
申请号：US15702162
申请日：2017-09-12
申请人： Neuralstem, Inc.
发明人： Karl K. JOHE
IPC分类号： A61K31/437 , A61K31/44 , A61K31/4439 , A61K31/496 , A61K31/444
CPC分类号： A61K31/437 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/455 , A61K31/496
摘要： Methods for treating non-systemic deficiencies associated with diabetes using 2-amino substituted nicotinamides or their pharmaceutically acceptable salts.
-
公开(公告)号：US09465025B2
公开(公告)日：2016-10-11
申请号：US12424238
申请日：2009-04-15
申请人： Renji Yang , Karl K. Johe
发明人： Renji Yang , Karl K. Johe
IPC分类号： C12N5/22 , C12N5/0797 , A61K35/30 , G01N33/50 , C12N5/16 , C12N5/0793 , G01N33/94 , A61K35/12
CPC分类号： G01N33/5058 , A61K35/12 , A61K35/30 , C12N5/0619 , C12N5/0623 , C12N5/16 , C12N2500/25 , C12N2500/90 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/148 , C12N2501/392 , C12N2501/395 , C12N2501/91 , C12N2506/02 , C12N2510/00 , C12N2510/02 , G01N33/5008 , G01N33/502 , G01N33/5073 , G01N33/9413
摘要： A systematic and efficient method for establishing stable neural stem cell lines and neuronal progenitor lines is described. The resulting cell lines provide robust, simple, and reproducible cultures of human and other mammalian neurons in commercially useful mass quantities while maintaining normal karyotypes and normal neuronal phenotypes.
-
公开(公告)号：US09278933B2
公开(公告)日：2016-03-08
申请号：US13392489
申请日：2010-08-24
申请人： Sripathy Venkatraman , Syed Mahmood , Bingidimi I. Mobele , Olga Lapina , Kellie Vercoe , Ying Li , Jonathan Salsbury , Mark McLaws
发明人： Sripathy Venkatraman , Syed Mahmood , Bingidimi I. Mobele , Olga Lapina , Kellie Vercoe , Ying Li , Jonathan Salsbury , Mark McLaws
IPC分类号： C07D213/32 , C07D213/82
CPC分类号： C07D213/74 , C07D213/82
摘要： The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.
-
公开(公告)号：US08058434B2
公开(公告)日：2011-11-15
申请号：US12939897
申请日：2010-11-04
IPC分类号： C07D239/02 , A61K31/505
CPC分类号： C07D239/48 , A61K31/437 , A61K31/4545 , A61K31/4985 , A61K31/505 , A61K35/12 , C07D239/49 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/5058 , G01N33/5073 , G01N33/6896
摘要： Compositions containing neurogenic agents for inhibition of neuron death and inducing proliferation of neural cells are disclosed.
摘要翻译： 公开了含有用于抑制神经元死亡和诱导神经细胞增殖的神经源性成分的组合物。
-
公开(公告)号：US10322115B2
公开(公告)日：2019-06-18
申请号：US15702162
申请日：2017-09-12
申请人： Neuralstem, Inc.
发明人： Karl K. Johe
IPC分类号： A61K31/44 , A61P25/00 , A61P25/02 , A61K31/437 , A61K31/444 , A61K31/455 , A61K31/496 , A61K31/4439
摘要： Methods for treating non-systemic deficiencies associated with diabetes using 2-amino substituted nicotinamides or their pharmaceutically acceptable salts.
-
公开(公告)号：US20190142829A1
公开(公告)日：2019-05-16
申请号：US15961419
申请日：2018-04-24
申请人： Neuralstem, Inc.
发明人： Karl K. JOHE
IPC分类号： A61K31/506 , A61P25/28 , A61P25/00 , A61B5/00 , A61B5/16
摘要： Treatment with 2-amino substituted nicotinamides or their salts ameliorates the cognitive and motor dysfunction associated with Angelman Syndrome (AS).
-
公开(公告)号：US09220730B2
公开(公告)日：2015-12-29
申请号：US13890787
申请日：2013-05-09
IPC分类号： A61K35/30 , C12N5/0797
CPC分类号： A61K35/30 , A61K9/0085 , C12N5/0623 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/148
摘要： The invention relates generally to methods of treating spasticity, rigidity, or muscular hyperactivity conditions by introducing a portion of an expanded population of neural stem cells into an area of a recipient spinal cord.
摘要翻译： 本发明一般涉及通过将一部分扩大的神经干细胞群引入受体脊髓的区域来治疗痉挛，僵硬或肌肉过度活动的方法。
-
公开(公告)号：US08362262B2
公开(公告)日：2013-01-29
申请号：US13269507
申请日：2011-10-07
IPC分类号： C07D401/00 , A61K31/44
CPC分类号： C07D239/48 , A61K31/437 , A61K31/4545 , A61K31/4985 , A61K31/505 , A61K35/12 , C07D239/49 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/5058 , G01N33/5073 , G01N33/6896
摘要： Compositions containing neurogenic agents for inhibition of neuron death and inducing proliferation of neural cells are disclosed.
摘要翻译： 公开了含有用于抑制神经元死亡和诱导神经细胞增殖的神经源性成分的组合物。
-
10.发明授权Transplantation of human neural cells for treatment of neurodegenerative conditions 有权人类神经细胞移植治疗神经退行性疾病公开(公告)号：US07691629B2
公开(公告)日：2010-04-06
申请号：US11281640
申请日：2005-11-17
申请人： Karl K. Johe , Thomas G. Hazel
发明人： Karl K. Johe , Thomas G. Hazel
IPC分类号： C12N5/08
CPC分类号： A61K35/30 , A61K9/0085 , C12N5/0623 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/148
摘要： A method of treating neurodegenerative conditions is provided. Neural stem cells may be implanted at and/or remote from a region of neuron degeneration. The methods can include isolating neural stem cells from regions where specific types of neurons corresponding to the neurons to be replaced are generated. The methods can include isolating neural stem cells secreting growth factors affecting the growth and/or regeneration of specific types of neuron. In this invention, we disclose a method of treating such disorders, including several neurodegenerative disorders arising from the lack of cells that produce particular neurotransmitters in neural circuitry by transplanting exogenously cultured and expanded neural progenitors which, upon transplantation into a neural tissue, differentiate into neurons capable of integrating and producing neurotransmitters in sufficient quantities and in a sufficient manner to overcome the symptoms associated with the neurodegeneration.
摘要翻译： 提供了一种治疗神经退行性疾病的方法。 神经干细胞可以在和/或远离神经元变性的区域植入。 这些方法可以包括从产生与被替换的神经元相对应的特定类型的神经元的区域分离神经干细胞。 所述方法可以包括分离分泌影响特定类型神经元的生长和/或再生的生长因子的神经干细胞。 在本发明中，我们公开了一种治疗这种疾病的方法，包括由缺乏通过移植外源培养和扩增的神经祖细胞产生特异性神经递质的神经递质产生的几种神经变性疾病的方法，所述神经祖细胞在移植到神经组织中分化为神经元 能够以足够的量和足够的方式整合和产生神经递质以克服与神经变性相关的症状。
-
-
-
-
-
-
-
-
-
搜索结果
40 条记录 (耗时 0.021 秒)
