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公开(公告)号：US20230136182A1
公开(公告)日：2023-05-04
申请号：US17898746
申请日：2022-08-30
发明人： Murat Guvendiren , Chya-Yan Liaw , Andrew House
IPC分类号： B29C64/295 , B29C64/118 , B29C64/209 , B29C64/245 , B29C64/393 , B33Y10/00 , B33Y50/02 , B33Y30/00
摘要： A method is disclosed for 3D printing thermally curable polymeric inks and their composites for scaffolds or devices. In this method, an extrusion based direct ink writing printing technology was used. The method includes an in-situ curing process and print layer height adjustment steps after each print layer to compensate for shrinkage during a thermal treatment step.
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2.发明申请公开(公告)号：US20220252536A1
公开(公告)日：2022-08-11
申请号：US17613807
申请日：2020-05-07
IPC分类号： G01N27/22 , B01J20/22 , C02F1/58 , C02F1/28 , C02F1/32 , C02F1/72 , G01N27/48 , G01N33/18 , G01N27/07
摘要： Materials for binding per- and polyfluoroalkyl substances (PFAS) are disclosed. A fluidic device comprising the materials for detection and quantification of PFAS in a sample is disclosed. The fluidic device may be configured for multiplexed analyses. Also disclosed are methods for sorbing and remediating PFAS in a sample. The sample may be groundwater containing, or suspected of containing, one or more PFAS.
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公开(公告)号：US11337881B2
公开(公告)日：2022-05-24
申请号：US16107041
申请日：2018-08-21
发明人： Madeline Corrigan , Richard Foulds
IPC分类号： A61H3/00 , A61H1/02 , G06F3/0338 , G06F3/01
摘要： A control system and method for an exoskeleton is provided. The control system utilizes the admittance control paradigm to provide a system and method for manipulating the exoskeleton using minimal force from the user. A force/torque sensor and servo motors are fitted onto a passive arm support, enabling motorized support for a user with upper extremity weaknesses. The exoskeleton may be used on any extremity. The admittance control paradigm includes an impedance control and an admittance control to allow a user with upper extremity weakness and limited independence to intuitively and with minimal force control the precise trajectory of their arms to achieve a greater degree of independence in activities of daily living. Unlike existing passive arm supports that utilize springs or rubber bands to balance the user's arm against gravity, this system provides more precise gravity compensation and minimizes the amount of force required to control the exoskeleton.
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公开(公告)号：US20220105470A1
公开(公告)日：2022-04-07
申请号：US17485932
申请日：2021-09-27
发明人： Wen Zhang , Weihua Qing
摘要： A pervaporation apparatus and method for liquid mixture separation are disclosed. The pervaporation disclosed utilizes an interfacial-heating membrane utilizing induction heating to provide temperature differences across the membrane for driving liquid mixture separation. The pervaporation system may include an electromagnetic induction heating device that is placed close to or encapsulated in a membrane module wherein one or more membranes with surfaces containing ferromagnetic or other induction-responsive materials. The membrane surface generates localized heat owing to the presence of a ferromagnetic composition that converts electric energy from an induction source to thermal energy. The ferromagnetic composition could include, without limitation, metals, metal alloys, composite materials, nanocomposite materials, nanoparticles, meshes, and combinations thereof.
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公开(公告)号：US20210388031A1
公开(公告)日：2021-12-16
申请号：US17348994
申请日：2021-06-16
发明人： Dr. Vivek A. Kumar
IPC分类号： C07K14/005 , G16B15/00
摘要： Disclosed is a new strategy, composition, and method for a self-assembling peptides (SAP) that will self-assemble atop COVID-19 for immune destruction and act as a functional COVID-19 opsonin. The designed self-assembling peptides bind and assemble atop SARS-CoV-2—providing a new mechanism of infection abrogation. One benefit is avoidance of side effects that other formulations or repurposed drugs contain. Other feature of this technology include: (a) (SAP) are composed of L-amino acids that are highly biocompatible sub-Q, IM and IV (no adverse reaction for 10% blood volume replacement with 1 w % peptide in mice or rats); (b) Highly targeted approach that binds to viral particles preventing side effects; (c) SAP are intrinsically biodegradable and endocytosed; (d) SAP bound COVID-19 may promote engulfment, clearance, and antigen presentation (for immunity development); and (e) targeting the spike protein with SAP may allow treatment of other coronaviruses.
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公开(公告)号：US20210369628A1
公开(公告)日：2021-12-02
申请号：US17289601
申请日：2019-10-31
发明人： Xiaoyang Xu , Yuanxiang Tao
IPC分类号： A61K9/50 , A61K9/00 , A61K31/137 , A61K31/4168 , A61K31/4174 , A61K31/485 , A61K31/573 , A61K31/135 , A61K31/5517 , A61K33/00 , A61K31/381 , A61K31/445 , A61K31/167 , A61K31/46 , A61P23/02
摘要： An injectable formulation for a sustained-release of a local anesthetic is provided. The formulation comprises a pharmaceutically effective amount of a local anesthetic encapsulated into polymeric particles having a diameter from about 1 μm to about 4 μm. Such formulation prolongs analgesic effect, decreases toxicity, and allows loading larger doses, and at the same time is injectable directly at a patient's body site of the interest without generating a surgical wound. Methods of use and preparation are also provided.
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公开(公告)号：US20210331121A1
公开(公告)日：2021-10-28
申请号：US17225424
申请日：2021-04-08
发明人： Somenath Mitra , Sagar Roy , Oindrila Gupta
摘要： A membrane distillation (MD) system includes a membrane module and reduced graphene oxide-carbon nanotube immobilized membrane for organic solvent separation. The MD module could include a feed inlet and outlet, a sweep gas inlet, and a sweep gas outlet. Thermostats are positioned at the feed inlet and outlet to measure the change in temperature. Preferential sorption of the organic, specifically tetrahydrofuran (THF), on a hybrid reduced graphene oxide-carbon nanotube immobilized membrane contributes to enhanced solvent removal of the MD system.
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8.发明申请公开(公告)号：US20210229106A1
公开(公告)日：2021-07-29
申请号：US17154872
申请日：2021-01-21
发明人： Jay Meegoda , Jitendra Kewalramani
IPC分类号： B02C19/18
摘要： Systems and methods to remediate, degrade, and/or remove pollutants within various contaminated environmental solid media that includes contaminated soils and sediments, biosolids and slurries by subjecting a mixture of the contaminated solids and a liquid to acoustic cavitation generated by more than one type of ultrasonic device. One of the ultrasonic devices operates at a low frequency and the other ultrasonic device operates at a high frequency. The system advantageously provide an efficient, sustainable, and easy to handle approach to degrade contaminant, requiring only electrical energy
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公开(公告)号：US10898894B2
公开(公告)日：2021-01-26
申请号：US16312091
申请日：2017-06-21
发明人： Eon Soo Lee , Bharath Babu Nunna , K. Stephen Suh
IPC分类号： G01N21/00 , B01L3/00 , G01N33/543
摘要： Improved diagnostic assemblies are provided. More particularly, the present disclosure provides improved and highly advantageous chip based diagnostic assemblies configured to detect human diseases (e.g., cancer) and/or pathogens, and related methods of use. In exemplary embodiments, the present disclosure provides for consumable micro- or nano-fluidic chip based diagnostic assemblies having visual biosensors, with the diagnostic assemblies using continuous flow-based micro- or nano-fluidic channels and antibody-based immuno-complex designs. In certain embodiments, the diagnostic assembly includes a self-sustainable and operable chip (e.g., thumb-sized chip) that is configured to be deployed as a single use consumable with a direct all-or-none readout as an output to satisfy a point of screening method to screen a population.
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公开(公告)号：US10828606B2
公开(公告)日：2020-11-10
申请号：US16031651
申请日：2018-07-10
发明人： Somenath Mitra , Sagar Roy
IPC分类号： B01D61/36
摘要： Radiative heating and radiative feed modification systems and methods using microwave, radio frequency, magnetic field and ultrasound in membrane separation processes including membrane distillation (MD), reverse osmosis, forward osmosis and pervaporation are disclosed. Membrane distillation systems include at least one MD module, the MD module having at least one membrane, a feed inlet operable to receive a feed media and a feed outlet, and a radiative energy source operable to apply radiation to a feed media entering the feed inlet.
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