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公开(公告)号:US20150342965A1
公开(公告)日:2015-12-03
申请号:US14655753
申请日:2013-12-26
申请人: OTIC PHARMA LTD.
发明人: Evgenia LOZINSKY , Yanna GALIBOV , Rodrigo YELIN
IPC分类号: A61K31/573 , A61K9/00 , A61K9/12 , A61K31/496
CPC分类号: A61K31/496 , A61K9/0046 , A61K9/107 , A61K9/12 , A61K9/122 , A61K31/4709 , A61K31/5383 , A61K31/573 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/38 , A61K2300/00
摘要: The present invention relates to foamable otic pharmaceutical compositions comprising oil-in-water emulsions which comprise an antibiotic agent and a propellant gas. The pharmaceutical compositions are administered to the ear as foam for treating ear disorders.
摘要翻译: 本发明涉及包含包含抗生素和推进剂气体的水包油乳液的可发泡耳用药物组合物。 将药物组合物作为治疗耳部疾病的泡沫施用于耳朵。
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公开(公告)号:US08783518B2
公开(公告)日:2014-07-22
申请号:US13142692
申请日:2009-12-27
申请人: Oz Cabiri , Rodrigo Yelin , Ella Zlatkis , Eran Eilat
发明人: Oz Cabiri , Rodrigo Yelin , Ella Zlatkis , Eran Eilat
CPC分类号: B65D83/52 , A61M15/0036 , A61M15/0045 , A61M15/009 , A61M2202/04 , A61M2209/06 , B05B15/55 , G01F11/028
摘要: A method for dispensing a plurality of metered doses of a fluid, comprising: providing a fluid in a container comprising a plurality of metering chambers and a plurality of tubes connectable to and movable relative to the chambers, wherein the tubes are externally open or open to the fluid; connecting to the chambers tubes open to the fluid, thereby loading the chambers with fluid; and selectively connecting one or more externally open tubes to one or more chambers, thereby dispensing the fluid contents of the one or more chambers via an external opening.
摘要翻译: 一种用于分配多个计量剂量的流体的方法,包括:在容器中提供流体,所述容器包括多个计量室和可连接到并可相对于所述室移动的多个管,其中所述管是外部打开的或敞开的 流体; 连接到对流体开放的腔室管,从而用流体加载腔室; 并且将一个或多个外部开放的管选择性地连接到一个或多个室,从而经由外部开口分配一个或多个室的流体内容物。
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3.
公开(公告)号:US20120252720A1
公开(公告)日:2012-10-04
申请号:US13437680
申请日:2012-04-02
申请人: Eran Eilat
发明人: Eran Eilat
IPC分类号: A61K31/573 , A61K31/7036 , A61K38/08 , A61K31/5383 , A61K31/496 , A61K31/56 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/10 , A61P23/00 , A61P31/12 , A61P17/00 , A61P35/00 , A61P19/00 , A61K31/245
CPC分类号: A61K9/122 , A61K9/0046 , A61K31/495 , Y10S514/945 , Y10S514/956
摘要: The present invention relates to compositions and methods useful for the treatment of ear disorders, administered to a treated ear in the form of a foam or a mousse. Administering a medicament in such forms will increase the residence time of the medicament in the ear canal, provide relatively uniform distribution of the composition, and can increase the penetration of the active pharmaceutical ingredient in the affected area, may release active substances slowly, enhance treatment effectiveness, increase compliance and is more convenient to use than currently available ear medications. The administration in the form of a foam or a mousse may preferably be provided as a metered dose, of a volume suitable to fill the ear canal.
摘要翻译: 本发明涉及用于治疗耳朵疾病的组合物和方法,其以泡沫或摩丝形式施用于治疗的耳朵。 以这种形式施用药物将增加药物在耳道中的停留时间,提供组合物的相对均匀的分布,并且可以增加活性药物成分在受影响区域中的渗透性,可缓慢释放活性物质,增强治疗 有效性,提高依从性,比目前可用的耳药更方便使用。 以泡沫或摩丝形式的施用可以优选地以适于填充耳道的体积计量剂量提供。
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公开(公告)号:US20120082627A1
公开(公告)日:2012-04-05
申请号:US13377090
申请日:2010-06-08
申请人: Rodrigo Yelin , Eran Eilat
发明人: Rodrigo Yelin , Eran Eilat
IPC分类号: A61K9/12 , A61K31/5383 , A61K31/4709 , A61P31/10 , A61K31/56 , A61P27/16 , A61P31/04 , A61K31/496 , A61K31/5395
CPC分类号: A61K9/122 , A61K9/0046 , A61K9/107 , A61K9/1075 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61K45/06 , A61K2300/00
摘要: The present invention relates to foamable otic pharmaceutical compositions comprising fluoroquinolones and methods of preparing same. Particularly, the present invention relates to pharmaceutical compositions comprising oil-in-water emulsions comprising fluoroquinolones and gas propellants, administered to the ear as foam for treating ear disorders.
摘要翻译: 本发明涉及包含氟喹诺酮类的可发泡耳用药物组合物及其制备方法。 特别地,本发明涉及包含氟喹诺酮类和气体推进剂的水包油乳剂的药物组合物,其作为泡沫用于耳部,用于治疗耳部疾病。
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公开(公告)号:US09789106B2
公开(公告)日:2017-10-17
申请号:US15385460
申请日:2016-12-20
申请人: OTIC PHARMA LTD.
发明人: Evgenia Lozinsky , Yanna Galibov , Rodrigo Yelin
IPC分类号: A61K31/496 , A61K9/107 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/26 , A61K47/12 , A61K47/20 , A61K47/38 , A61K47/32 , A61K9/12 , A61K9/00
CPC分类号: A61K31/496 , A61K9/0046 , A61K9/107 , A61K9/12 , A61K9/122 , A61K31/4709 , A61K31/5383 , A61K31/573 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/38 , A61K2300/00
摘要: The present invention relates a foamable otic pharmaceutical compositions comprising oil-in water emulsions which comprise an antibiotic agent and a propellant gas. The pharmaceutical compositions are administered to the ear as foam for treating ear disorders.
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公开(公告)号:US09393242B2
公开(公告)日:2016-07-19
申请号:US13220350
申请日:2011-08-29
申请人: Eran Eilat
发明人: Eran Eilat
IPC分类号: A61K9/12 , A61F9/02 , A61K31/19 , A61K31/495 , A61K9/00
CPC分类号: A61K31/495 , A61K9/0046 , A61K9/122 , Y10S514/945 , Y10S514/956
摘要: The present invention relates to compositions and methods useful for the treatment of ear disorders, administered to a treated ear in the form of a foam or a mousse. Administering a medicament in such forms will increase the residence time of the medicament in the ear canal, provide relatively uniform distribution of the composition, and can increase the penetration of the active pharmaceutical ingredient in the affected area, may release active substances slowly, enhance treatment effectiveness, increase compliance and is more convenient to use than currently available ear medications. The administration in the form of a foam or a mousse may preferably be provided as a metered dose, of a volume suitable to fill the ear canal.
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公开(公告)号:US20140234227A1
公开(公告)日:2014-08-21
申请号:US14350948
申请日:2012-10-10
申请人: OTIC PHARMA LTD
发明人: Rodrigo Yelin , Jorge Danziger , Eran Eilat
IPC分类号: A61K31/573 , A61K9/12 , A61K31/496
CPC分类号: A61K9/122 , A61K9/0046 , A61K9/12 , A61K31/4709 , A61K31/496 , A61K31/573 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/38 , A61K2300/00
摘要: The present invention provides foamable pharmaceutical compositions comprising water-soluble antibiotics and anti-inflammatory steroids and methods of preparing same. Particularly, the present invention relates to oil-free pharmaceutical compositions comprising a quinolone, an anti-inflammatory steroid, a polar co-solvent, and propellant gas, administered to the ear in the form of foam for treating ear disorders.
摘要翻译: 本发明提供了包含水溶性抗生素和抗炎类固醇的可发泡药物组合物及其制备方法。 特别地,本发明涉及无水药物组合物,其包含喹诺酮,抗炎类固醇,极性助溶剂和推进剂气体,以泡沫形式施用于耳朵以治疗耳部疾病。
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8.
公开(公告)号:US08030362B2
公开(公告)日:2011-10-04
申请号:US10582712
申请日:2004-12-12
申请人: Eran Eilat
发明人: Eran Eilat
CPC分类号: A61K31/495 , A61K9/0046 , A61K9/122 , Y10S514/945 , Y10S514/956
摘要: The present invention relates to compositions and methods useful for the treatment of ear disorders, administered to a treated ear in the form of a foam or a mousse. Administering a medicament in such forms will increase the residence time of the medicament in the ear canal, provide relatively uniform distribution of the composition, and can increase the penetration of the active pharmaceutical ingredient in the affected area, may release active substances slowly, enhance treatment effectiveness, increase compliance and is more convenient to use than currently available ear medications. The administration in the form of a foam or a mousse may preferably be provided as a metered dose, of a volume suitable to fill the ear canal.
摘要翻译: 本发明涉及用于治疗耳朵疾病的组合物和方法,其以泡沫或摩丝形式施用于治疗的耳朵。 以这种形式施用药物将增加药物在耳道中的停留时间,提供组合物的相对均匀的分布,并且可以增加活性药物成分在受影响区域中的渗透性,可缓慢释放活性物质,增强治疗 有效性,提高依从性,比目前可用的耳药更方便使用。 以泡沫或摩丝形式的施用可以优选地以适于填充耳道的体积计量剂量提供。
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公开(公告)号:US20170105991A1
公开(公告)日:2017-04-20
申请号:US15385460
申请日:2016-12-20
申请人: OTIC PHARMA LTD.
发明人: Evgenia LOZINSKY , Yanna GALIBOV , Rodrigo YELIN
IPC分类号: A61K31/496 , A61K45/06 , A61K47/06 , A61K47/10 , A61K9/00 , A61K47/26 , A61K47/12 , A61K47/20 , A61K47/38 , A61K47/32 , A61K9/107 , A61K9/12
CPC分类号: A61K31/496 , A61K9/0046 , A61K9/107 , A61K9/12 , A61K9/122 , A61K31/4709 , A61K31/5383 , A61K31/573 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/38 , A61K2300/00
摘要: The present invention relates a foamable otic pharmaceutical compositions comprising oil-in water emulsions which comprise an antibiotic agent and a propellant gas. The pharmaceutical compositions are administered to the ear as foam for treating ear disorders.
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公开(公告)号:US09561240B2
公开(公告)日:2017-02-07
申请号:US14655753
申请日:2013-12-26
申请人: OTIC PHARMA LTD.
发明人: Evgenia Lozinsky , Yanna Galibov , Rodrigo Yelin
IPC分类号: A61K31/573 , A61K9/12 , A61K31/4709 , A61K9/00 , A61K9/107 , A61K31/496 , A61K31/5383
CPC分类号: A61K31/496 , A61K9/0046 , A61K9/107 , A61K9/12 , A61K9/122 , A61K31/4709 , A61K31/5383 , A61K31/573 , A61K45/06 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/26 , A61K47/32 , A61K47/38 , A61K2300/00
摘要: The present invention relates to foamable otic pharmaceutical compositions comprising oil-in-water emulsions which comprise an antibiotic agent and a propellant gas. The pharmaceutical compositions are administered to the ear as foam for treating ear disorders.
摘要翻译: 本发明涉及包含包含抗生素和推进剂气体的水包油乳液的可发泡耳用药物组合物。 将药物组合物作为治疗耳部疾病的泡沫施用于耳朵。
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