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公开(公告)号：US20210338593A1
公开(公告)日：2021-11-04
申请号：US17368401
申请日：2021-07-06
申请人： Board of Regents of the University of Texas System , The Ohio State University Research Foundation
发明人： Mauro Ferrari , Ennio Tasciotti , Jason Sakamoto
IPC分类号： A61K9/50 , A61K9/51 , A61K31/165 , A61K9/127 , A61K31/704 , A61K31/7088
摘要： Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
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公开(公告)号：US10384943B2
公开(公告)日：2019-08-20
申请号：US15666249
申请日：2017-08-01
发明人： Avetik Harutyunyan , Elena Pigos , Toshio Tokune
IPC分类号： D01F9/12 , C01B32/162 , B82Y30/00 , B82Y40/00 , D01F9/127
摘要： Method and processes for synthesizing single-wall carbon nanotubes is provided. A carbon precursor gas is contacted with metal catalysts deposited on a support material. The metal catalysts are preferably nanoparticles having diameters less than about 50 nm. The reaction temperature is selected such that it is near the eutectic point of the mixture of metal catalyst particles and carbon.
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公开(公告)号：US20190111000A1
公开(公告)日：2019-04-18
申请号：US16158644
申请日：2018-10-12
申请人： Board of Regents of the University of Texas System , The Ohio State University Research Foundation
发明人： Mauro Ferrari , Ennio Tasciotti , Jason Sakamoto
IPC分类号： A61K9/50 , A61K31/7088 , A61K31/704 , A61K9/51 , A61K9/127 , A61K31/165
摘要： Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.
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公开(公告)号：US20170275625A1
公开(公告)日：2017-09-28
申请号：US15484446
申请日：2017-04-11
申请人： The Ohio State University Research Foundation , The Government of the United States of America, as represented by the Secretary of the Department of
IPC分类号： C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12Q1/6809 , C12Q1/6886 , C12Q2525/207 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , Y10T436/143333
摘要： Described herein are methods and compositions for the treatment of colon cancers.
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5.发明授权Compositions and methods for the diagnosis and therapy of BCL2-associated cancers 有权用于诊断和治疗BCL2相关癌症的组合物和方法公开(公告)号：US09480699B2
公开(公告)日：2016-11-01
申请号：US14341145
申请日：2014-07-25
发明人： Carlo M. Croce , George A. Calin
IPC分类号： A61K31/7105 , C12N15/113 , C12Q1/68 , A61K31/713 , A61K9/127 , A61K45/06 , A61N5/10
CPC分类号： A61K31/7105 , A61K9/127 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/1135 , C12N2310/141 , C12N2310/53 , C12N2320/31 , C12Q1/6886
摘要： Provided are methods and compositions for the treatment of cancers associated with overexpression of a BCL2 gene and/or gene product in a subject, and methods and compositions for the improvement of anti-cancer therapy, such as chemotherapy and radiation therapy. Also provided are methods for determining the efficacy of a cancer therapy in a subject, methods for diagnosing cancer, methods for assessing patient prognosis, and methods for inducing apoptosis of a cell.
摘要翻译： 提供了用于治疗与受试者中BCL2基因和/或基因产物的过度表达相关的癌症的方法和组合物，以及用于改善抗癌治疗如化疗和放射治疗的方法和组合物。 还提供了用于确定受试者的癌症治疗的功效的方法，用于诊断癌症的方法，用于评估患者预后的方法以及诱导细胞凋亡的方法。
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6.发明申请MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Breast Cancer 审中-公开用于乳腺癌诊断，预后和治疗的基于微RNA的方法和组合物公开(公告)号：US20160251659A1
公开(公告)日：2016-09-01
申请号：US15155479
申请日：2016-05-16
发明人： Carlo M. Croce , George A. Calin
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/141 , C12N2320/30 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , Y02A90/26
摘要： The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of breast cancer. The invention also provides methods of identifying anti-breast cancer agents.
摘要翻译： 本发明提供了用于乳腺癌诊断，预后和治疗的新方法和组合物。 本发明还提供鉴定抗乳腺癌药物的方法。
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7.发明授权C-linked glucuronide of N-(4-hydroxybenzyl) retinone, analogs thereof, and methods of using the same to inhibit neoplastic cell growth 有权N-（4-羟基苄基）视黄醛的C-连接葡糖苷酸，其类似物及其用于抑制肿瘤细胞生长的方法公开(公告)号：US09359322B2
公开(公告)日：2016-06-07
申请号：US13106537
申请日：2011-05-12
申请人： Margaret Clagett-Dame , Robert W. Curley, Jr. , Joel R. Walker , Hussein Abou-Issa , Galal A. Alshafie
发明人： Margaret Clagett-Dame , Robert W. Curley, Jr. , Joel R. Walker , Hussein Abou-Issa , Galal A. Alshafie
IPC分类号： A61K31/7034 , A61P35/00 , C07H7/04 , C07D309/10 , C07H15/04 , C07H15/203
CPC分类号： C07D309/10 , C07H15/04 , C07H15/203
摘要： Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.
摘要翻译： 描述式的化合物以及含有这些化合物的药物组合物，以及使用该化合物预防和治疗包括人在内的哺乳动物的癌症的方法。
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8.发明申请Methods for Differentiating Pancreatic Cancer from Normal Pancreatic Function and/or Chronic Pancreatitis 审中-公开将胰腺癌与正常胰腺功能和/或慢性胰腺炎分化的方法公开(公告)号：US20150094357A1
公开(公告)日：2015-04-02
申请号：US14564522
申请日：2014-12-09
发明人： Carlo M. Croce
IPC分类号： C12Q1/68 , C12N15/113
CPC分类号： C12Q1/6886 , C12N15/113 , C12N2310/141 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178
摘要： There is provided herein methods and compositions for the diagnosis, prognosis and treatment of pancreatic cancer, along with methods of identifying anti-pancreatic cancer agents.
摘要翻译： 本文提供了用于胰腺癌的诊断，预后和治疗的方法和组合物，以及鉴定抗胰腺癌剂的方法。
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公开(公告)号：US20140342466A1
公开(公告)日：2014-11-20
申请号：US14288532
申请日：2014-05-28
申请人： THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
CPC分类号： G01N1/405 , B01D15/00 , B01D15/08 , B01J20/103 , B01J20/2808 , B01J2220/54 , B01L3/5023 , B82Y5/00 , C07K1/30 , C07K1/34 , G01N33/6803 , Y10T436/2525 , Y10T436/255
摘要： Nanoporous materials can be used to enrich samples for subsequent analysis of substances contained in the sample. The method is shown to enrich the yield of species in the low molecular weight proteome, allowing detection of small peptides in the low nanomolar range.
摘要翻译： 可以使用纳米多孔材料来富集样品，以便随后分析样品中所含的物质。 该方法显示为丰富低分子量蛋白质组中物种的产量，允许检测低纳摩尔范围内的小肽。
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公开(公告)号：US08865885B2
公开(公告)日：2014-10-21
申请号：US13925954
申请日：2013-06-25
发明人： Carlo M. Croce , Ramiro Garzon , George A. Calin
IPC分类号： C07H21/04 , C12N15/113 , C12Q1/68 , A61K45/06 , A61K31/7105
CPC分类号： C12N15/1135 , A61K31/7105 , A61K45/06 , C12N15/113 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178 , C12Q2525/207
摘要： Described herein is a pharmaceutical composition for treating a subject having a cancer and/or myeloproliferative disorder associated with overexpression of a HOXA1 gene product where an effective amount of at least one miR-10a gene product or an isolated variant or biologically-active fragment thereof is administered to the subject sufficient to decrease expression of the HOXA1 gene product in the subject.
摘要翻译： 本文描述的是用于治疗与HOXA1基因产物的过度表达相关的癌症和/或骨髓增生性疾病的受试者的药物组合物，其中有效量的至少一种miR-10a基因产物或其分离的变体或生物活性片段是 给予受试者足以减少受试者中HOXA1基因产物的表达。
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