公开(公告)号：US20080091253A1

公开(公告)日：2008-04-17

申请号：US11871931

申请日：2007-10-12

申请人： Amy Hammack ,  Jeff Callister ,  Paul Stull ,  Alex Roth ,  William Tremulis

发明人： Amy Hammack ,  Jeff Callister ,  Paul Stull ,  Alex Roth ,  William Tremulis

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61B2017/00084 ,  A61B2017/00088 ,  A61B2017/00867 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126

摘要： A catheter system for controlling the body temperature of a patient by modifying the temperature of blood flowing within a blood vessel of the patient. The catheter system comprises a catheter body having a heat exchange region in contact with the blood; and a temperature probe having a distal end that extends from the catheter body, thereby monitoring the temperature of blood flowing within the blood vessel.

摘要翻译： 一种用于通过改变在患者的血管内流动的血液的温度来控制患者体温的导管系统。 导管系统包括具有与血液接触的热交换区域的导管体; 以及温度探头，其具有从导管主体延伸的远端，从而监测在血管内流动的血液的温度。

公开(公告)号：US07258662B2

公开(公告)日：2007-08-21

申请号：US10645263

申请日：2003-08-20

申请人： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

发明人： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

IPC分类号： A61F7/00

CPC分类号： A61F7/0085 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/00199 ,  A61B2017/22051 ,  A61F7/0097 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/12 ,  A61M2205/127

摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

公开(公告)号：US07077825B1

公开(公告)日：2006-07-18

申请号：US10051870

申请日：2002-01-16

申请人： Paul M. Stull

发明人： Paul M. Stull

IPC分类号： A61F7/12

CPC分类号： A61F7/123 ,  A61F2007/0022 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0095

摘要： A balloon catheter is used in a closed-loop heat exchange system for manipulating the temperature of a patient. The balloon catheter is positioned in the stomach of the patient, and then expanded with a heat exchange fluid delivered through a lumen formed in the shaft of the catheter. The balloon catheter comes into contact with the wall of the stomach, and the stomach substantially conforms around the expanded balloon catheter. The heat exchange fluid is allowed to flow continuously into and out of the balloon catheter. Heat is exchanged between the balloon catheter and the stomach so as to controllably alter the temperature of at least a portion of the patient. Anti-shivering mechanisms and automatic control based on temperature feedback from the patient may be used in connection with the heat exchange system.

摘要翻译： 气囊导管用于闭环热交换系统，用于操纵患者的温度。 气囊导管定位在患者的胃中，然后通过在导管的轴中形成的内腔递送的热交换流体膨胀。 气囊导管与胃壁接触，胃部基本上与扩张的气囊导管相适应。 允许热交换流体连续地流入和流出气囊导管。 在球囊导管和胃之间交换热量，以便可控地改变患者的至少一部分的温度。 基于来自患者的温度反馈的防颤动机构和自动控制可以与热交换系统结合使用。

公开(公告)号：US07008444B2

公开(公告)日：2006-03-07

申请号：US10676880

申请日：2003-10-01

申请人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

发明人： Michael W. Dae ,  Timothy R. Machold ,  Wade A. Keller

IPC分类号： A61F7/00

CPC分类号： A61M25/00 ,  A61B2017/00084 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0295 ,  A61F2007/126 ,  A61M2205/36

摘要： A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an α2-adrenoreceptor agonist, a non-opiod analgesic monoamine uptake inhibitor or neuropeptide that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various α2-adrenoreceptor agonistα2-adrenoreceptor agonists, non-opiod analgesic monoamine uptake inhibitors and neuropeptides are disclosed including dexmedetomidine, nefopam, neurotensin and anticonvulsant medications and pharmaceutically acceptable salts thereof. A control system for the control of the patient's temperature is disclosed for controlling the patient's temperature in conjunction with administering the α2-adrenoreceptor agonist, non-opiod analgesic monoamine uptake inhibitor or neuropeptide.

摘要翻译： 一种用于降低患者体温的方法和装置，同时通过使用热交换装置与α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽暂时减轻发抖相结合来减轻发抖。 所公开的装置包括具有热交换球囊的导管，其中热交换流体循环通过气囊的内部。 将热交换球放置在患者的脉管系统中，并且在脉管系统中除血液温度以外的温度下的热交换流体循环通过气囊的内部以从患者的血液中添加或除去热量。 公开了各种α2-肾上腺素受体激动剂α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂和神经肽，包括右美托咪定，奈福泮，神经降压素和抗惊厥药物及其药学上可接受的盐。 公开了用于控制患者体温的控制系统，用于与施用α2-肾上腺素受体激动剂，非阿片类镇痛单胺摄取抑制剂或神经肽一起控制患者的温度。

公开(公告)号：US20050209658A1

公开(公告)日：2005-09-22

申请号：US11125604

申请日：2005-05-09

申请人： Timothy Machold ,  Nicole Bloom ,  Alex Roth ,  Dave Scott ,  Jose Alejandro ,  Edward Oliver

发明人： Timothy Machold ,  Nicole Bloom ,  Alex Roth ,  Dave Scott ,  Jose Alejandro ,  Edward Oliver

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61F2/958 ,  A61F7/00 ,  A61F7/10 ,  A61F7/12 ,  A61N1/00 ,  F04B43/08 ,  F28F7/00

CPC分类号： A61F7/12 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/22051 ,  A61F7/0085 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M5/44 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/127

摘要： A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.

摘要翻译： 用于将热交换流体供应到血管内热交换导管的热交换流体供应系统包括具有隔板和外部热交换器的一次性盒，其被配置为与可重复使用的主控制单元结合操作。 舱壁包括储存段和泵段。 储存器部分设置有用于监测系统中的热交换流体的量的装置。 隔板提供了使用来自外部源的热交换流体并且用于在闭合回路中将流体循环到导管的系统引发系统的机构。 泵部分构造成允许在恒定压力下泵送热交换流体。

公开(公告)号：US20050159673A1

公开(公告)日：2005-07-21

申请号：US11080128

申请日：2005-03-14

申请人： Michael Dae ,  Timothy Machold ,  Paul Stull

发明人： Michael Dae ,  Timothy Machold ,  Paul Stull

IPC分类号： A61B5/00 ,  A61B5/01 ,  A61B18/18

CPC分类号： A61B5/01 ,  A61B5/6851 ,  A61B5/6853

摘要： A temperature sensing system and method for determining a patient's core body temperature by measuring the temperature of the patient's blood at a location in a vessel lumen retrograde of an insertion point of a temperature sensor or sensors into the vessel lumen.

摘要翻译： 一种温度感测系统和方法，用于通过测量血管腔内的位置处的患者血液的温度来将温度传感器或传感器的插入点逆行到血管腔中来确定患者的核心体温。

公开(公告)号：US20050113893A1

公开(公告)日：2005-05-26

申请号：US11017710

申请日：2004-12-22

申请人： Mark Saab

发明人： Mark Saab

IPC分类号： A61F2/958 ,  A61F7/00 ,  A61F7/12 ,  A61M25/00 ,  A61M29/02

CPC分类号： A61F7/123 ,  A61B2018/00166 ,  A61F2007/0054 ,  A61F2007/126 ,  A61M25/0009 ,  A61M25/0029 ,  A61M25/0032 ,  A61M25/1027 ,  A61M25/1029 ,  A61M25/104 ,  A61M29/02 ,  A61M2025/0025 ,  A61M2025/0031 ,  A61M2025/0034 ,  A61M2025/0036 ,  A61M2025/1031 ,  A61M2025/1072 ,  A61M2025/1075 ,  A61M2025/1086

摘要： Heat transfer catheter apparatus and methods of making and using same are disclosed wherein a fluid connection is provided between the distal portions of two adjacent, thin-walled, high strength fluid lumens to define a closed loop fluid circulation system capable of controlled delivery of thermal energy to or withdrawal of thermal energy from remote internal body locations.

公开(公告)号：US20030014094A1

公开(公告)日：2003-01-16

申请号：US09905389

申请日：2001-07-13

申请人： Radiant Medical, Inc.

发明人： Amy L. Hammack ,  Jeff P. Callister ,  Paul M. Stull ,  Alex T. Roth ,  William S. Tremulis

IPC分类号： A61F007/00

CPC分类号： A61F7/12 ,  A61B2017/00084 ,  A61B2017/00088 ,  A61B2017/00867 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126

摘要： A catheter system for controlling the body temperature of a patient by modifying the temperature of blood flowing within a blood vessel of the patient. The catheter system comprises a catheter body having a heat exchange region in contact with the blood; and a temperature probe having a distal end that extends from the catheter body, thereby monitoring the temperature of blood flowing within the blood vessel.

摘要翻译： 一种用于通过改变在患者的血管内流动的血液的温度来控制患者体温的导管系统。 导管系统包括具有与血液接触的热交换区域的导管体; 以及温度探头，其具有从导管主体延伸的远端，从而监测在血管内流动的血液的温度。

公开(公告)号：US20020183692A1

公开(公告)日：2002-12-05

申请号：US10142659

申请日：2002-05-08

申请人： Radiant Medical, Inc.

发明人： Jeffrey P. Callister

IPC分类号： H05B001/00 ,  A61F007/12

CPC分类号： A61F7/123 ,  A61F2007/0054 ,  A61F2007/126 ,  Y02P20/142 ,  Y10T428/24942

摘要： The heat exchange catheters comprise a catheter body having a heat exchange structure formed over a distal region thereof. Heat exchange structure comprises an elastic chamber or balloon which conforms closely to the catheter body when uninflated and which expands to enhance the available heat transfer surface when heat exchange medium is introduced. The elastic structures may consist of elastomeric sheets or membranes or may comprise non-distensible sheets or membranes having elastic elements in order to control expansion and contraction. Methods for fabrication and use are also disclosed.

摘要翻译： 热交换导管包括在其远端区域上形成有热交换结构的导管体。 热交换结构包括弹性室或球囊，其在未膨胀时与导管主体紧密配合，并且当引入热交换介质时膨胀以增强可用传热表面。 弹性结构可以由弹性片或膜组成，或者可以包括具有弹性元件的不扩张片或膜，以便控制膨胀和收缩。 还公开了制造和使用的方法。

公开(公告)号：US20020111616A1

公开(公告)日：2002-08-15

申请号：US09735314

申请日：2000-12-12

申请人： Radiant Medical, Inc.

发明人： Michael W. Dea ,  Wade A. Keller ,  Timothy R. Machold

IPC分类号： A61B018/18

CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/126 ,  A61M25/1002

摘要： Methods and apparatus for preventing myocardial infarction, or lessening the size/severity of an evolving myocardial infarction, by cooling at least the affected area of the myocardium using an intravascular heat exchange catheter. The heat exchange catheter may be inserted into the vasculature (e.g., a vein) and advanced to a position wherein a heat exchanger on the catheter is located in or near the heart (e.g., within the vena cava near the patient's heart). Thereafter, the heat exchange catheter is used to cool the myocardium (or the entire body of the patient) to a temperature that effectively lessens the metabolic rate and/or oxygen consumption of the ischemic myocardial cells or otherwise protects the ischemic myocardium from undergoing irreversible damage or infarction.

摘要翻译： 通过使用血管内热交换导管至少冷却至少心肌的受影响区域来预防心肌梗死或减轻心肌梗死的大小/严重程度的方法和装置。 热交换导管可以插入脉管系统（例如静脉）中并且前进到导管上的热交换器位于心脏中或附近（例如在患者心脏附近的腔静脉内）的位置。 此后，热交换导管用于将心肌（或患者的整个身体）冷却到有效降低缺血心肌细胞的代谢率和/或氧消耗的温度，或以其它方式保护缺血心肌免受不可逆损伤 或梗死。