公开(公告)号：US20070117224A1

公开(公告)日：2007-05-24

申请号：US11284155

申请日：2005-11-21

申请人： Kevin Croker ,  Michael Damore ,  Kostantinos Kourtakis ,  Michael Perry ,  James Prober ,  Paul Stull

发明人： Kevin Croker ,  Michael Damore ,  Kostantinos Kourtakis ,  Michael Perry ,  James Prober ,  Paul Stull

IPC分类号： G01N33/552

CPC分类号： G01N33/54346 ,  B82Y30/00

摘要： A microsphere for use in a bioassay comprising a glass core coated with a nanoparticle composite comprising a bioactive probe is provided. The nanoparticle composite coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in enhanced dynamic range and sensitivity in bioassays. The particle may be used in detection systems where resonant light scattering properties of the particle are useful.

摘要翻译： 提供了用于生物测定的微球，其包括涂覆有包含生物活性探针的纳米颗粒复合物的玻璃核心。 纳米颗粒复合涂层增强了微球表面生物探针加载的密度，从而提高了生物测定中的动态范围和灵敏度。 该颗粒可用于其中共聚光散射性质有用的检测系统中。

公开(公告)号：US07896009B2

公开(公告)日：2011-03-01

申请号：US11474590

申请日：2006-06-26

申请人： Paul Stull

发明人： Paul Stull

IPC分类号： A61B19/00

CPC分类号： A61F7/123 ,  A61F2007/0022 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0095

摘要： A balloon catheter is used in a closed-loop heat exchange system for manipulating the temperature of a patient. The balloon catheter is positioned in the stomach of the patient, and then expanded with a heat exchange fluid delivered through a lumen formed in the shaft of the catheter. The balloon catheter comes into contact with the wall of the stomach, and the stomach substantially conforms around the expanded balloon catheter. The heat exchange fluid is allowed to flow continuously into and out of the balloon catheter. Heat is exchanged between the balloon catheter and the stomach so as to controllably alter the temperature of at least a portion of the patient. Anti-shivering mechanisms and automatic control based on temperature feedback from the patient may be used in connection with the heat exchange system.

摘要翻译： 气囊导管用于闭环热交换系统，用于操纵患者的温度。 气囊导管定位在患者的胃中，然后通过在导管的轴中形成的内腔递送的热交换流体膨胀。 气囊导管与胃壁接触，胃部基本上与扩张的气囊导管相适应。 允许热交换流体连续地流入和流出气囊导管。 在球囊导管和胃之间交换热量，以便可控地改变患者的至少一部分的温度。 基于来自患者的温度反馈的防颤动机构和自动控制可以与热交换系统结合使用。

公开(公告)号：US20070020661A1

公开(公告)日：2007-01-25

申请号：US11459885

申请日：2006-07-25

申请人： Melissa CUNNINGHAM ,  Paul STULL ,  William WEISBURG

发明人： Melissa CUNNINGHAM ,  Paul STULL ,  William WEISBURG

IPC分类号： C12Q1/68 ,  C12N1/08

CPC分类号： C12Q1/6895 ,  C12Q1/6893 ,  Y02A50/451

摘要： The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Crytosporidium organisms, and Crytosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligonucleotides of the present invention include hybridization assay probes, helper probes and amplification primers. The present invention further describes a novel method for obtaining purified ribonucleic acid from viable oocysts.

摘要翻译： 本发明描述了针对衍生自Crytosporidium生物体的核酸序列和特别是Crytosporidium parvum生物体的新型寡核苷酸，其可用于确定测试样品中隐孢子虫生物体的存在。 本发明的寡核苷酸包括杂交测定探针，辅助探针和扩增引物。 本发明还描述了一种用于从活的卵囊中获得纯化的核糖核酸的新方法。

公开(公告)号：US20060122673A1

公开(公告)日：2006-06-08

申请号：US10525625

申请日：2003-09-12

申请人： Jeffrey Callister ,  Paul Stull ,  Andrew Wu ,  David Scott

发明人： Jeffrey Callister ,  Paul Stull ,  Andrew Wu ,  David Scott

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61F7/12 ,  A61F7/007 ,  A61F7/0085 ,  A61F2007/0054 ,  A61F2007/0075 ,  A61F2007/0086 ,  A61F2007/0096 ,  A61F2007/126 ,  G05D23/1925

摘要： Systems and methods for accurate temperature modification of a patient, or selected regions thereof, including inducing hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette attached to the circulatory flow lines of the catheter, the heat exchange cassette being sized to engage a cavity within a control unit. A temperature measurement scheme for obtaining body core temperature is provided, including methods of obtaining and analyzing temperature data to provide feedback to the control unit for use in controlling the heating and cooling of the heat exchange medium so as to heat or cool a patient to a desired target temperature.

摘要翻译： 用于患者或其选定区域的精确温度改变的系统和方法，包括诱导低体温。 使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。 附接到导管的循环流动管线的热交换盒，所述热交换盒的尺寸适于接合控制单元内的空腔。 提供了一种用于获得体芯温度的温度测量方案，包括获得和分析温度数据以向控制单元提供反馈以用于控制热交换介质的加热和冷却以便将患者加热或冷却到 所需目标温度。

公开(公告)号：US20050288551A1

公开(公告)日：2005-12-29

申请号：US11115771

申请日：2005-04-27

申请人： Jeffrey Callister ,  William Tremulis ,  Laura Kemp ,  Paul Stull

发明人： Jeffrey Callister ,  William Tremulis ,  Laura Kemp ,  Paul Stull

IPC分类号： A61B1/00 ,  A61B1/012 ,  A61B1/018 ,  A61B1/04 ,  A61B1/303 ,  A61B17/12 ,  A61B17/42 ,  A61F6/18 ,  A61F6/22

CPC分类号： A61B1/018 ,  A61B1/00082 ,  A61B1/00133 ,  A61B1/04 ,  A61B1/303 ,  A61B5/4839 ,  A61B17/12022 ,  A61B17/12172 ,  A61B17/12177 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/4233 ,  A61B2090/037 ,  A61F6/225

摘要： The invention is directed to an endoscopic assembly having an endoscope, particularly a flexible hysteroscope and an outer sheath disposed about a length of the shaft of the hysteroscope which has an expandable member such as an inflatable balloon for sealing the assembly within a body lumen or cavity. Specifically, the endoscope assembly is configured for delivery of an occlusive contraceptive member to the patient's fallopian tube. The invention is also directed to an endoscope having a driving member for movement of a medical device within the working lumen of an endoscope. In one embodiment the driving member is a friction wheel which engages an elongated medical device disposed within the working channel of the endoscope to effect longitudinal movement of the medical device.

摘要翻译： 本发明涉及具有内窥镜，特别是柔性宫腔镜的内窥镜组件和围绕宫腔镜的轴的长度设置的外护套，其具有可膨胀构件，例如可膨胀气囊，用于将组件密封在体腔或腔内 。 具体地，内窥镜组件构造成用于将闭塞性避孕构件输送到患者的输卵管。 本发明还涉及具有用于在内窥镜的工作腔内移动医疗装置的驱动部件的内窥镜。 在一个实施例中，驱动构件是摩擦轮，其接合设置在内窥镜的工作通道内的细长医疗装置，以实现医疗装置的纵向移动。

公开(公告)号：US20060253095A1

公开(公告)日：2006-11-09

申请号：US11474590

申请日：2006-06-26

申请人： Paul Stull

发明人： Paul Stull

IPC分类号： A61M31/00

CPC分类号： A61F7/123 ,  A61F2007/0022 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0095

摘要： A balloon catheter is used in a closed-loop heat exchange system for manipulating the temperature of a patient. The balloon catheter is positioned in the stomach of the patient, and then expanded with a heat exchange fluid delivered through a lumen formed in the shaft of the catheter. The balloon catheter comes into contact with the wall of the stomach, and the stomach substantially conforms around the expanded balloon catheter. The heat exchange fluid is allowed to flow continuously into and out of the balloon catheter. Heat is exchanged between the balloon catheter and the stomach so as to controllably alter the temperature of at least a portion of the patient. Anti-shivering mechanisms and automatic control based on temperature feedback from the patient may be used in connection with the heat exchange system.

公开(公告)号：US2538172A

公开(公告)日：1951-01-16

申请号：US71750846

申请日：1946-12-20

申请人： PAUL STULL

发明人： PAUL STULL

IPC分类号： H05C1/00

CPC分类号： H05C1/00 ,  Y10T307/865

公开(公告)号：US20080091253A1

公开(公告)日：2008-04-17

申请号：US11871931

申请日：2007-10-12

申请人： Amy Hammack ,  Jeff Callister ,  Paul Stull ,  Alex Roth ,  William Tremulis

发明人： Amy Hammack ,  Jeff Callister ,  Paul Stull ,  Alex Roth ,  William Tremulis

IPC分类号： A61F7/12

CPC分类号： A61F7/12 ,  A61B2017/00084 ,  A61B2017/00088 ,  A61B2017/00867 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126

摘要： A catheter system for controlling the body temperature of a patient by modifying the temperature of blood flowing within a blood vessel of the patient. The catheter system comprises a catheter body having a heat exchange region in contact with the blood; and a temperature probe having a distal end that extends from the catheter body, thereby monitoring the temperature of blood flowing within the blood vessel.

摘要翻译： 一种用于通过改变在患者的血管内流动的血液的温度来控制患者体温的导管系统。 导管系统包括具有与血液接触的热交换区域的导管体; 以及温度探头，其具有从导管主体延伸的远端，从而监测在血管内流动的血液的温度。

公开(公告)号：US20070117089A1

公开(公告)日：2007-05-24

申请号：US11283664

申请日：2005-11-21

申请人： Kevin Croker ,  Michael Damore ,  Kostantinos Kourtakis ,  Michael Perry ,  James Prober ,  Paul Stull

发明人： Kevin Croker ,  Michael Damore ,  Kostantinos Kourtakis ,  Michael Perry ,  James Prober ,  Paul Stull

IPC分类号： C12Q1/70 ,  G01N33/53 ,  C12M3/00

CPC分类号： G01N33/54346 ,  B82Y30/00

摘要： A microsphere for use in a bioassay comprising a glass core coated with a sol-gel comprising a bioactive probe is provided. The sol-gel coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in enhanced dynamic range and sensitivity in bioassays. The particle may be used in detection systems where resonant light scattering properties of the particle are useful.

摘要翻译： 提供了用于生物测定的微球，其包括涂覆有包含生物活性探针的溶胶 - 凝胶的玻璃核心。 溶胶 - 凝胶涂层增强了微球表面生物探针加载的密度，从而提高了生物测定中的动态范围和灵敏度。 该颗粒可用于其中共聚光散射性质有用的检测系统中。

公开(公告)号：US20050159673A1

公开(公告)日：2005-07-21

申请号：US11080128

申请日：2005-03-14

申请人： Michael Dae ,  Timothy Machold ,  Paul Stull

发明人： Michael Dae ,  Timothy Machold ,  Paul Stull

IPC分类号： A61B5/00 ,  A61B5/01 ,  A61B18/18

CPC分类号： A61B5/01 ,  A61B5/6851 ,  A61B5/6853

摘要： A temperature sensing system and method for determining a patient's core body temperature by measuring the temperature of the patient's blood at a location in a vessel lumen retrograde of an insertion point of a temperature sensor or sensors into the vessel lumen.

摘要翻译： 一种温度感测系统和方法，用于通过测量血管腔内的位置处的患者血液的温度来将温度传感器或传感器的插入点逆行到血管腔中来确定患者的核心体温。