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    Renal injury inhibiting devices, systems, and methods employing low-frequency ultrasound or other cyclical pressure energies
    1.
    发明授权
    Renal injury inhibiting devices, systems, and methods employing low-frequency ultrasound or other cyclical pressure energies 有权
    使用低频超声波或其他周期性压力能量的肾损伤抑制装置，系统和方法

    公开(公告)号：US08585597B2

    公开(公告)日：2013-11-19

    申请号：US13047618

    申请日：2011-03-14

    申请人： Michael Dae ,  Claire Andrews

    发明人： Michael Dae ,  Claire Andrews

    IPC分类号： A61B8/00

    CPC分类号： A61N7/00 ,  A61B6/507 ,  A61B8/08 ,  A61B8/4477 ,  A61B8/481 ,  A61M1/14 ,  A61N2007/0004 ,  A61N2007/0078 ,  A61N2007/0082

    摘要： Improved devices, systems, and methods treatment of patients can be used to help mitigate injury to the kidneys by applying cyclical mechanical pressure energy at low intensities. The energy often be selectively directed from non-invasive transducers disposed outside the patients. The energy will typically comprise low frequency ultrasound energy, shock wave energy, or the like, and may induce the generation and/or release of nitric oxide, thereby enhancing perfusion and ameliorating tissue damage. Superimposed micro and macro duty cycles may help avoid thermal and other injury to tissues of the patient during treatment. Bilateral treatments are facilitated by a support structure that orients at least one transducer toward each kidney.

    摘要翻译： 改进的设备，系统和方法治疗患者可用于通过在低强度下施加周期性机械压力能量来帮助减轻对肾脏的损伤。 能量通常从布置在患者外部的非侵入性换能器选择性导向。 能量通常包括低频超声能量，冲击波能量等，并且可以诱导一氧化氮的产生和/或释放，从而增强灌注并改善组织损伤。 叠加的微观和微观占空比可能有助于避免治疗期间患者组织的热和其他损伤。 通过支撑结构来促进双侧治疗，所述支撑结构为每个肾定向至少一个换能器。

    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
    3.
    发明申请
    Inhibition of platelet activation, aggregation and/or adhesion by hypothermia 有权
    通过低温抑制血小板活化，聚集和/或粘附

    公开(公告)号：US20070038277A1

    公开(公告)日：2007-02-15

    申请号：US11501442

    申请日：2006-08-08

    申请人： Michael Dae ,  Timothy Machold ,  Wade Keller

    发明人： Michael Dae ,  Timothy Machold ,  Wade Keller

    IPC分类号： A61F7/00 ,  A61F7/12

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/126

    摘要： A method for treating acute coronary syndromes (i.e., unstable angina or non-Q-wave MI) or transient ischemic attacks in a human or animal patient by placing a heat exchange apparatus in the patient's vasculature and using that heat exchange apparatus to cool the patient to a temperature (e.g. 30-36° C.) at which platelet inhibition (i.e., inhibition of platelet activation and/or aggregation and/or adhesion) occurs. Anti-shivering drugs or anesthesia may be administered to patients whose body temperature is cooled below that patient's shivering threshold (typically approximately 35.5 C). If it is determined that platelet inhibition is no longer desirable, such as when the patient is about to undergo a surgical or interventional procedure wherein bleeding could be problematic, the hypothermia-induced platelet inhibition may be rapidly reversed by using the intravascular heat exchange apparatus to re-warm the patient's body to normothermia or near normothermia.

    摘要翻译： 一种通过将热交换装置放置在患者的脉管系统中并使用该热交换装置来冷却患者来治疗人或动物患者的急性冠状动脉综合征（即不稳定型心绞痛或非Q波MI）或短暂性脑缺血发作的方法 达到血小板抑制（即，抑制血小板活化和/或聚集和/或粘附）的温度（例如30-36℃）。 可以向体温冷却到患者发抖阈值以下（通常约35.5℃）的患者施用抗发抖药物或麻醉。 如果确定不再需要血小板抑制，例如当患者即将进行其中出血可能有问题的手术或介入手术时，通过使用血管内热交换装置可以快速逆转低体温诱导的血小板抑制 将患者的身体重温为正常体温或接近正常体温。

    Intra-aortic balloon counterpulsation with concurrent hypothermia
    4.
    发明申请
    Intra-aortic balloon counterpulsation with concurrent hypothermia 有权
    主动脉内气囊反搏与并发低温

    公开(公告)号：US20050043579A1

    公开(公告)日：2005-02-24

    申请号：US10933970

    申请日：2004-09-02

    申请人： Michael Dae ,  Timothy Machold

    发明人： Michael Dae ,  Timothy Machold

    IPC分类号： A61B17/00 ,  A61F7/00 ,  A61F7/10 ,  A61F7/12 ,  A61M1/10 ,  A61M19/00 ,  A61M25/00 ,  A61N1/362

    CPC分类号： A61M1/1086 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0095 ,  A61F2007/126 ,  A61M1/106 ,  A61M1/107 ,  A61M1/1072 ,  A61M1/1074 ,  A61M1/125 ,  A61M19/00 ,  A61M2205/3606 ,  A61M2230/04

    摘要： Devices, systems and methods for treating disorders characterized by low cardiac output. The devices, systems and methods use intra-aortic balloon counterpulsation in combination with hypothermia of all or a portion of a human or veterinary patient's body to improve coronary perfusion and cardiac output. To effect the hypothermia, a heat exchange catheter may be positioned in the a patient's vasculature separately from the intra-aortic balloon counterpulsation catheter. Alternatively, a combination Intra-aortic balloon counterpulsation/heat exchange catheter may be utilized. Such combination catheter comprises a) a catheter sized for insertion into the aorta, b) a counterpulsation balloon and c) a heat exchanger. A drive/control system receives temperature and electrocardiograph signals and drives the inflation/deflation of the counterpulsation balloon as well as the heating/cooling of the heat exchanger.

    摘要翻译： 用于治疗以低心输出量为特征的疾病的装置，系统和方法。 装置，系统和方法使用主动脉内气囊反搏与人或兽医患者身体的全部或一部分的低体温结合以改善冠状动脉灌注和心输出量。 为了降低体温，可以将热交换导管与主动脉内气囊反搏导管分开设置在患者的脉管系统中。 或者，可以使用主动脉内球囊反搏/热交换导管的组合。 这种组合导管包括a）尺寸适于插入主动脉的导管，b）反力气囊和c）热交换器。 驱动/控制系统接收温度和心电图仪信号并驱动反力气囊的充气/放气以及热交换器的加热/冷却。

    Renal Injury Inhibiting Devices, Systems, and Methods Employing Low-Frequency Ultrasound or Other Cyclical Pressure Energies
    6.
    发明申请
    Renal Injury Inhibiting Devices, Systems, and Methods Employing Low-Frequency Ultrasound or Other Cyclical Pressure Energies 有权
    使用低频超声或其他循环压力能量的肾损伤抑制装置，系统和方法

    公开(公告)号：US20120065501A1

    公开(公告)日：2012-03-15

    申请号：US13047618

    申请日：2011-03-14

    申请人： Michael Dae ,  Claire Andrews

    发明人： Michael Dae ,  Claire Andrews

    IPC分类号： A61B6/00 ,  A61N7/00

    CPC分类号： A61N7/00 ,  A61B6/507 ,  A61B8/08 ,  A61B8/4477 ,  A61B8/481 ,  A61M1/14 ,  A61N2007/0004 ,  A61N2007/0078 ,  A61N2007/0082

    摘要： Improved devices, systems, and methods treatment of patients can be used to help mitigate injury to the kidneys by applying cyclical mechanical pressure energy at low intensities. The energy often be selectively directed from non-invasive transducers disposed outside the patients. The energy will typically comprise low frequency ultrasound energy, shock wave energy, or the like, and may induce the generation and/or release of nitric oxide, thereby enhancing perfusion and ameliorating tissue damage. Superimposed micro and macro duty cycles may help avoid thermal and other injury to tissues of the patient during treatment. Bilateral treatments are facilitated by a support structure that orients at least one transducer toward each kidney.

    摘要翻译： 改进的设备，系统和方法治疗患者可用于通过在低强度下施加周期性机械压力能量来帮助减轻对肾脏的损伤。 能量通常从布置在患者外部的非侵入性换能器选择性导向。 能量通常包括低频超声能量，冲击波能量等，并且可以诱导一氧化氮的产生和/或释放，从而增强灌注并改善组织损伤。 叠加的微观和微观占空比可能有助于避免治疗期间患者组织的热和其他损伤。 通过支撑结构来促进双侧治疗，所述支撑结构为每个肾定向至少一个换能器。

    Method for reducing myocardial infarct by application of intravascular hypothermia
    7.
    发明申请
    Method for reducing myocardial infarct by application of intravascular hypothermia 有权
    通过应用血管内低温降低心肌梗塞的方法

    公开(公告)号：US20050027290A1

    公开(公告)日：2005-02-03

    申请号：US10933979

    申请日：2004-09-02

    申请人： Michael Dae ,  Wade Keller ,  Timothy Machold

    发明人： Michael Dae ,  Wade Keller ,  Timothy Machold

    IPC分类号： A61F2/958 ,  A61F7/00 ,  A61F7/12 ,  A61B18/04

    CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/126 ,  A61M25/1002

    摘要： Methods and apparatus for preventing myocardial infarction, or lessening the size/severity of an evolving myocardial infarction, by cooling at least the affected area of the myocardium using an intravascular heat exchange catheter. The heat exchange catheter may be inserted into the vasculature (e.g., a vein) and advanced to a position wherein a heat exchanger on the catheter is located in or near the heart (e.g., within the vena cava near the patient's heart). Thereafter, the heat exchange catheter is used to cool the myocardium (or the entire body of the patient) to a temperature that effectively lessens the metabolic rate and/or oxygen consumption of the ischemic myocardial cells or otherwise protects the ischemic myocardium from undergoing irreversible damage or infarction.

    摘要翻译： 通过使用血管内热交换导管至少冷却至少心肌的受影响区域来预防心肌梗死或减轻心肌梗死的大小/严重程度的方法和装置。 热交换导管可以插入脉管系统（例如静脉）中并且前进到导管上的热交换器位于心脏中或附近（例如在患者心脏附近的腔静脉内）的位置。 此后，热交换导管用于将心肌（或患者的整个身体）冷却到有效降低缺血心肌细胞的代谢率和/或氧消耗的温度，或以其它方式保护缺血心肌免受不可逆损伤 或梗死。