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    1H-imidazo�4,5-c!quinolin-4-amines
    1.
    发明授权
    1H-imidazo�4,5-c!quinolin-4-amines 失效
    1H-咪唑并[4,5-c]喹啉-4-胺

    公开(公告)号：US5756747A

    公开(公告)日：1998-05-26

    申请号：US455273

    申请日：1995-05-31

    申请人： John F. Gerster

    发明人： John F. Gerster

    IPC分类号： C07D215/42 ,  C07D471/04

    CPC分类号： C07D215/42

    摘要： Novel 1H-imidazo�4,5-c!quinolin-4-amines are disclosed. The compounds function as antiviral agents and they are potential synthetic intermediates in the preparation of known antiviral agents and labeled known antiviral agents. Processes for the preparation of the compounds, methods for their antiviral use, and methods of inducing interferon biosynthesis, are also described.

    摘要翻译： 公开了新的1H-咪唑并[4,5-c]喹啉-4-胺。 该化合物作为抗病毒剂起作用，并且它们是制备已知抗病毒剂和标记的已知抗病毒剂的潜在的合成中间体。 还描述了制备化合物的方法，其抗病毒用途的方法和诱导干扰素生物合成的方法。

    Di-t-butylphenols substituted by an alkoxy or benzyloxy group or a benzylthio group
    4.
    发明授权
    Di-t-butylphenols substituted by an alkoxy or benzyloxy group or a benzylthio group 失效
    被烷氧基或苄氧基或苄硫基取代的二叔丁基酚

    公开(公告)号：US5066822A

    公开(公告)日：1991-11-19

    申请号：US571925

    申请日：1990-06-29

    申请人： Mark A. Rustad

    发明人： Mark A. Rustad

    IPC分类号： C07C59/68 ,  C07C65/24 ,  C07C255/53 ,  C07D257/04

    CPC分类号： C07D257/04 ,  C07C255/00 ,  C07C323/00 ,  C07C59/68 ,  C07C65/24

    摘要： Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by an alkoxy or benzyloxy group or a benzylthio group, which alkoxy or benzyloxy group is directly substituted by a tetrazole ring, and which benzylthio group is directly substituted by carboxy or tetrazolyl are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Synthetic intermediates for preparing such compounds are also described.

    摘要翻译： 通过烷氧基或苄氧基或苄硫基取代4位的2,6-二叔丁基酚的新型化合物，该烷氧基或苄氧基直接被四唑环取代，该苄硫基直接被四唑环取代 羧基或四唑基可用作白三烯生物合成的抑制剂和抗过敏药。 还描述了用于制备这种化合物的合成中间体。

    Substituted di-t-butylphenols and anti-allergic use thereof
    5.
    发明授权
    Substituted di-t-butylphenols and anti-allergic use thereof 失效
    取代的二叔丁基酚及其抗过敏应用

    公开(公告)号：US5049572A

    公开(公告)日：1991-09-17

    申请号：US593342

    申请日：1990-10-01

    申请人： Robert A. Scherrer ,  Mark A. Rustad

    发明人： Robert A. Scherrer ,  Mark A. Rustad

    IPC分类号： A61K31/325 ,  C07C233/64 ,  C07D257/04

    CPC分类号： C07D257/04 ,  C07C255/00

    摘要： Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by a carbamyl or acylamino group, which carbamyl or acylamino group is substituted by a group which includes an acidic substituent are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Pharmacological methods for using such compounds and synthetic intermediates for preparing such compounds are also disclosed.

    摘要翻译： 作为氨基甲酰基或酰氨基取代4位的2,6-二叔丁基酚的新型化合物，该氨基甲酰基或酰氨基被包含酸性取代基的基团取代，可用作白三烯生物合成抑制剂和抗过敏药 代理商 还公开了使用这些化合物和合成中间体制备这些化合物的药理学方法。

    Powder inhalation device
    6.
    发明授权
    Powder inhalation device 失效
    粉末吸入装置

    公开(公告)号：US4860740A

    公开(公告)日：1989-08-29

    申请号：US13191

    申请日：1987-02-10

    申请人： William F. Kirk ,  Anthony C. L. Wass ,  Eric A. Baum ,  Ian P. Tansey ,  William G. Meredith

    发明人： William F. Kirk ,  Anthony C. L. Wass ,  Eric A. Baum ,  Ian P. Tansey ,  William G. Meredith

    IPC分类号： A61M13/00 ,  A61M15/00

    CPC分类号： A61M15/0028 ,  A61M15/0031 ,  A61M15/0065 ,  A61M2202/064

    摘要： A device facilitating the inhalation of powdered medicaments from within a container. The device comprises a body having walls partially defining a chamber, an inlet port into the chamber for the entry of air, and a mouthpiece having a central through opening communicating with the chamber. A support member also partially defines the chamber and is manually movable relative to the body to convey a first portion of the container from (1) a first position spaced from the chamber to (2) a predetermined dispense position within the chamber with an open end of the first capsule portion uppermost so that airflow into the inlet port and through the chamber induced by suction at the mouthpiece will cause the powdered medicament in the first container portion to become entrained in the airflow; and an extractor is mounted for movement relative to the body to remove a second container portion and open the container prior to positioning of the first container portion at the dispense position.

    摘要翻译： 一种便于从容器内吸入粉末状药物的装置。 该装置包括具有部分地限定腔室的壁的主体，进入空气入口的入口端口以及具有与腔室连通的中心通孔的接口管。 支撑构件还部分地限定腔室并且可手动地相对于主体移动以将容器的第一部分从（1）与腔隔开的第一位置传送到（2）腔室内的预定分配位置，开口端 第一胶囊部分最上部，使得通过吸嘴处的吸引引入入口和通过腔室的气流将导致第一容器部分中的粉末药物被夹带在气流中; 并且提取器被安装成相对于主体移动以去除第二容器部分并且在将第一容器部分定位在分配位置之前打开容器。

    1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use
    8.
    发明授权
    1H-Imidazo[4,5-c]quinolin-4-amines and antiviral use 失效
    1H-咪唑并[4,5-c]喹啉-4-胺和抗病毒用途

    公开(公告)号：US4689338A

    公开(公告)日：1987-08-25

    申请号：US798385

    申请日：1985-11-15

    申请人： John F. Gerster

    发明人： John F. Gerster

    IPC分类号： A61K31/47 ,  C07D215/42 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D215/42

    摘要： 1H-Imidazo[4,5-c]quinolin-4-amines which are antivirals. Pharmacological methods of using such compounds and pharmaceutical compositions containing such compounds are also described.

    摘要翻译： 1H-咪唑并[4,5-c]喹啉-4-胺，其为抗病毒剂。 还描述了使用这些化合物的药理学方法和含有这些化合物的药物组合物。