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公开(公告)号：US11850237B2
公开(公告)日：2023-12-26
申请号：US17169907
申请日：2021-02-08
IPC分类号： A61K31/426 , A61K31/454 , A61K31/496 , A61K31/675 , A61K31/7105 , A61K45/06 , H01L31/12 , A61K31/215 , A61K31/351 , A61K9/00 , A61K9/20
CPC分类号： A61K31/426 , A61K9/0053 , A61K9/2086 , A61K31/215 , A61K31/351 , A61K31/454 , A61K31/496 , A61K31/675 , A61K31/7105 , A61K45/06 , H01L31/125 , A61K2300/00 , A61K31/426 , A61K2300/00 , A61K31/454 , A61K2300/00 , A61K31/496 , A61K2300/00 , A61K31/675 , A61K2300/00 , A61K31/7105 , A61K2300/00
摘要： This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
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公开(公告)号：US11135202B2
公开(公告)日：2021-10-05
申请号：US15474267
申请日：2017-03-30
IPC分类号： A61K31/426 , A61K45/06
摘要： Thiazolide compounds, such as nitazoxanide and/or tizoxanide, may be used against viruses belonging to the Picornaviridae family or the Paramyxoviridae family.
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公开(公告)号：US10912768B2
公开(公告)日：2021-02-09
申请号：US16448267
申请日：2019-06-21
IPC分类号： A61K31/426 , A61K31/454 , A61K31/496 , A61K31/675 , A61K31/7105 , A61K45/06 , H01L31/12 , A61K31/215 , A61K31/351 , A61K9/00 , A61K9/20
摘要： This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
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公开(公告)号：US20180126722A1
公开(公告)日：2018-05-10
申请号：US15861234
申请日：2018-01-03
CPC分类号： B41F11/00 , A61K31/426 , A61K38/212 , A61K38/47 , A61K39/39 , A61K45/06 , A61K2039/55511 , B41F7/025 , B41F7/06 , B41F7/08 , B41F9/021 , B41F13/18 , B41F13/193 , Y02A50/41 , Y02A50/414 , Y02A50/489 , A61K2300/00
摘要： The invention provides for the use of pharmaceutical compositions comprising a thiazolide in the stimulation of the immune system in a subject in need thereof, thereby preventing and/or treating viral diseases, cancer and diseases caused by intracellular protozoan infections
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公开(公告)号：US09107913B2
公开(公告)日：2015-08-18
申请号：US14137280
申请日：2013-12-20
IPC分类号： A61K31/425 , A61K31/70 , A61K38/00 , A61K31/426 , A61K38/21 , A61K45/06 , A61K31/7068
CPC分类号： A61K31/426 , A61K31/7068 , A61K38/21 , A61K38/212 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to methods for treating viral hepatitis, compounds useful in the treatment of viral hepatitis, and pharmaceutical compositions comprising such compounds. In one embodiment, pharmaceutical compositions comprising nitazoxanide, tizoxanide, or derivatives and/or mixtures thereof are provided, as well as methods of treating hepatitis C using such compositions.
摘要翻译： 本公开涉及治疗病毒性肝炎的方法，可用于治疗病毒性肝炎的化合物和包含这些化合物的药物组合物。 在一个实施方案中，提供了包含硝唑尼特，替佐昔奈或其衍生物和/或其混合物的药物组合物，以及使用这些组合物治疗丙型肝炎的方法。
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公开(公告)号：US5886013A
公开(公告)日：1999-03-23
申请号：US847130
申请日：1997-05-01
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： A61K31/426 , A61K31/522 , A61K31/7068
摘要： The present invention relates to a pharmaceutical composition containing a compound of formula I ##STR1## with one of the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 representing OH, whereas the remaining symbols represent H as antiviral agent.
摘要翻译： 本发明涉及包含式I化合物的药物组合物，其中符号R1，R2，R3，R4和R5之一代表OH，而其余符号代表H作为抗病毒剂。
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公开(公告)号：US20190307730A1
公开(公告)日：2019-10-10
申请号：US16448267
申请日：2019-06-21
IPC分类号： A61K31/426 , A61K9/20 , A61K9/00 , A61K31/351 , A61K31/215 , A61K31/496 , A61K31/454 , A61K45/06 , A61K31/7105 , A61K31/675 , H01L31/12
摘要： This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
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公开(公告)号：US10336058B2
公开(公告)日：2019-07-02
申请号：US15861234
申请日：2018-01-03
IPC分类号： A61K31/42 , B41F11/00 , A61K39/39 , A61K45/06 , A61K31/426 , A61K38/21 , A61K38/47 , B41F7/02 , B41F7/06 , B41F7/08 , B41F9/02 , B41F13/18 , B41F13/193 , A61K39/00
摘要： The invention provides for the use of pharmaceutical compositions comprising a thiazolide in the stimulation of the immune system in a subject in need thereof, thereby preventing and/or treating viral diseases, cancer and diseases caused by intracellular protozoan infections.
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9.发明申请公开(公告)号：US20190040026A1
公开(公告)日：2019-02-07
申请号：US16153070
申请日：2018-10-05
IPC分类号： C07D277/58 , A61P35/00 , A61K31/555 , A61P31/12 , A61K45/06 , C07D277/46 , A61K31/138 , A61K9/48 , A61K31/506 , A61K9/20 , A61K31/426 , A61P31/04 , A61K31/704 , A61K31/7068
CPC分类号： C07D277/58 , A61K9/20 , A61K9/48 , A61K31/138 , A61K31/426 , A61K31/506 , A61K31/555 , A61K31/704 , A61K31/7068 , A61K45/06 , A61P31/04 , A61P31/12 , A61P35/00 , C07D277/46 , A61K2300/00
摘要： Prodrugs of tizoxanide, an analogue or salt thereof are disclosed. The prodrugs have an ester moiety comprising an amino acid moiety, and increase the bioavailability of the tizoxanide, an analogue or salt thereof. Compositions and methods of treating an intracellular protozoan infection, a viral infection or a cancer are also disclosed.
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公开(公告)号：US09820975B2
公开(公告)日：2017-11-21
申请号：US15133534
申请日：2016-04-20
IPC分类号： A61K31/426 , A61K31/454 , A61K31/496 , A61K31/675 , A61K31/7105 , A61K45/06 , H01L31/12 , A61K31/215 , A61K31/351 , A61K9/00 , A61K9/20
CPC分类号： A61K31/426 , A61K9/0053 , A61K9/2086 , A61K31/215 , A61K31/351 , A61K31/454 , A61K31/496 , A61K31/675 , A61K31/7105 , A61K45/06 , A61K2300/00 , H01L31/125
摘要： This invention is directed to methods for treating and preventing influenza infection by inhibiting influenza virus HA maturation processes employing compounds of formula I. It is also directed to combinations for treating and preventing influenza infection comprising compounds of formula I and other agents.
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