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公开(公告)号：US09309322B2
公开(公告)日：2016-04-12
申请号：US13884899
申请日：2011-11-14
CPC分类号： C07K16/28 , A61K9/0019 , A61K39/39558 , A61K45/06 , A61K47/6809 , A61K47/6811 , A61K47/6849 , A61K47/6851 , C07K2317/24 , C07K2317/33 , C07K2317/35 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The present invention is directed to particular antibodies and fragments thereof that find use in the detection, prevention and treatment of diseases and disorders associated with abnormal angiogenesis. In particular, these antibodies detect tumor endothelial marker 8 (TEM8) in its native and cell-surface expressed form. Also disclosed are improved methods for producing monoclonal antibodies, as well as pharmaceutical compositions and kits.
摘要翻译： 本发明涉及可用于检测，预防和治疗与异常血管生成相关的疾病和病症的特定抗体及其片段。 特别地，这些抗体以其天然和细胞表面表达形式检测肿瘤内皮标志物8（TEM8）。 还公开了用于生产单克隆抗体的改进方法，以及药物组合物和试剂盒。
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公开(公告)号：US09180063B2
公开(公告)日：2015-11-10
申请号：US14096909
申请日：2013-12-04
发明人： Paul A. Friedman
CPC分类号： A61H3/00 , A61G5/00 , A61H3/02 , A61H3/04 , A61H2003/0205 , A61H2201/0184 , A61H2201/5007 , A61H2201/5028 , A61H2201/5048 , A61H2201/5069 , A61H2201/5097 , G08B21/0415 , G08B21/0461 , G08C17/02 , G08C19/00
摘要： Cognitive orthotics. More specifically, assistive ambulation systems and methods, including systems that can detect a person who uses an assistive ambulation device (such as a walker) and produce a signal in response to the detection, which signal is designed to encourage or motivate the person to use the device. They system may also stop the signal when the person engages the device and/or produce an additional signal or a different signal when the person engages the device.
摘要翻译： 认知矫形器。 更具体地，辅助行走系统和方法，包括可以检测使用辅助行走装置（例如步行器）的人并响应于检测产生信号的系统，该信号被设计为鼓励或激励该人使用 装置。 当人员接合设备时，他们的系统还可能停止信号，和/或当人员接合设备时产生附加信号或不同的信号。
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公开(公告)号：US09745381B2
公开(公告)日：2017-08-29
申请号：US14402009
申请日：2013-05-18
发明人： Jen-Sing Liu , Shu-Ru Kuo
CPC分类号： C07K16/30 , C07K16/2809 , C07K16/2866 , C07K16/2896 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/732 , C07K2317/92
摘要： Certain embodiments are directed to a bispecific immunoglobulin that is capable of binding cell surface molecules on a target cell, such as cancer cells, and cell surface molecules on immune effector cell, such as cytotoxic T lymphocytes, resulting in the targeted killing of target cells. In certain aspects a Bif is a polypeptide comprising a first target binding domain that specifically binds a cancer cell, a second effector binding domain that specifically binds an immunologic effector, and an immunoglobulin constant region linker operatively coupling the first and second binding domain.
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公开(公告)号：US09220922B2
公开(公告)日：2015-12-29
申请号：US14559717
申请日：2014-12-03
发明人： Andrew Morrow , Brian Massingill
CPC分类号： A61N5/1049 , A61B6/0492 , A61B6/08 , A61B6/102
摘要： Clearance check devices, systems, and methods that can be used to indicate whether a proposed treatment plan will cause a collision between a patient/couch and a medical device, such as a linac, are described herein. Some devices and/or systems include an adjustable clearance member to account for the rotation of the medical device and a rotatable frame segment to account for the rotation of the patient or couch. Others include a frame segment that has an inner surface defining an arc that has a radius that is substantially equal to or less than an orbital radius of a centermost portion of a medical equipment component. Still others are disclosed.
摘要翻译： 这里描述了可用于指示所提出的治疗计划是否会导致患者/沙发和医疗设备（例如直线加速器）之间的碰撞的间隙检查装置，系统和方法。 一些装置和/或系统包括可调节的间隙构件以解决医疗装置的旋转和可旋转的框架部分，以解决患者或沙发的旋转。 其他包括框架段，其具有限定弧的内表面，该内表面具有基本上等于或小于医疗设备部件的中心部分的轨道半径的半径。 还有一些被披露。
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