公开(公告)号：US11911452B2

公开(公告)日：2024-02-27

申请号：US17471825

申请日：2021-09-10

申请人： SANOFI PASTEUR INC. ,  SK BIOSCIENCE CO., LTD.

发明人： Kyungjun An ,  Dongsoo Ham ,  Hun Kim ,  Sunghyun Kim ,  Jinhwan Shin ,  Robert Hopfer ,  Richard D. Kensinger ,  Moe Kyaw ,  Philippe Talaga

IPC分类号： C12P21/06 ,  A61K39/09 ,  A61K9/00 ,  A61K39/00

CPC分类号： A61K39/092 ,  A61K9/0019 ,  A61K2039/6031 ,  A61K2039/70

摘要： Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 21 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid (TT) or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11 A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F, where the capsular polysaccharides of two of serotypes 1, 3, and 5 and one or both of serotypes 15B and 22F are conjugated to TT and the remaining capsular polysaccharides are conjugated to CRM197. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.

公开(公告)号：US11707514B2

公开(公告)日：2023-07-25

申请号：US17468989

申请日：2021-09-08

申请人： Sanofi Pasteur Inc.

发明人： Richard David Kensinger, Jr. ,  Steven L. Hauser

IPC分类号： A61K39/095 ,  A61K47/65 ,  A61K47/64 ,  A61K47/18 ,  A61K47/36 ,  A61K39/00

CPC分类号： A61K39/095 ,  A61K47/18 ,  A61K47/36 ,  A61K47/6415 ,  A61K47/65 ,  A61K2039/55583 ,  A61K2039/6037 ,  A61K2039/70 ,  Y02A50/30

摘要： Provided herein are compounds, compositions, formulations, kits, uses, and methods for vaccinating a subject against Neisseria meningitidis.

公开(公告)号：US20230121059A1

公开(公告)日：2023-04-20

申请号：US17802758

申请日：2021-02-26

申请人： Sanofi Pasteur Inc.

发明人： Lee-Jah Chang ,  Victoria Landolfi ,  Therese Quinn

IPC分类号： A61K39/145 ,  A61P31/14

摘要： Disclosed herein are immunogenic compositions and vaccination regimes for immunizing humans against influenza disease.

公开(公告)号：US20210401964A1

公开(公告)日：2021-12-30

申请号：US17468989

申请日：2021-09-08

申请人： Sanofi Pasteur Inc.

发明人： Richard David Kensinger, JR. ,  Steven L. Hauser

IPC分类号： A61K39/095 ,  A61K47/65 ,  A61K47/64 ,  A61K47/18 ,  A61K47/36

摘要： Provided herein are compounds, compositions, formulations, kits, uses, and methods for vaccinating a subject against Neisseria meningitidis.

公开(公告)号：US11147866B2

公开(公告)日：2021-10-19

申请号：US16282080

申请日：2019-02-21

申请人： Sanofi Pasteur Inc.

发明人： Richard David Kensinger, Jr. ,  Steven L. Hauser

IPC分类号： A61K39/095 ,  A61K47/65 ,  A61K47/64 ,  A61K47/18 ,  A61K47/36 ,  A61K39/00

摘要： Provided herein are compounds, compositions, formulations, kits, uses, and methods for vaccinating a subject against Neisseria meningitidis.

公开(公告)号：US11116832B2

公开(公告)日：2021-09-14

申请号：US16306325

申请日：2017-06-02

申请人： Sanofi Pasteur Inc.

发明人： Tod Strugnell ,  Eliud Oloo ,  Raymond Oomen

IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K16/18 ,  C07K16/28 ,  A61K45/06 ,  A61K39/145 ,  A61P31/16 ,  C07K14/005 ,  C12N7/00

摘要： The present invention provides, among other things, modified recombinant HA polypeptides with broadened immunogenic profile that extends coverage to antigenically distinct influenza strains and methods of making and using the same.

公开(公告)号：US20210077608A1

公开(公告)日：2021-03-18

申请号：US16966584

申请日：2019-02-04

申请人： SANOFI PASTEUR INC. ,  SK BIOSCIENCE CO., LTD.

发明人： Kyungjun AN ,  Dongsoo HAM ,  Hun KIM ,  Sunghyun KIM ,  Jinhwan SHIN ,  Robert HOPFER ,  Richard D. KENSINGER ,  Moe KYAW ,  Philippe TALAGA

IPC分类号： A61K39/09

摘要： Provided are mixed carrier, multivalent pneumococcal conjugate compositions comprising 21 different pneumococcal capsular polysaccharide-protein conjugates, wherein each of the conjugates includes a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to either tetanus toxoid (TT) or CRM197, wherein the Streptococcus pneumoniae serotypes are selected from 1, 3, 4, 5, 6A, 6B, 7F, 8, 9N, 9V, 10A, 11 A, 12F, 14, 15B, 18C, 19A, 19F, 22F, 23F, and 33F, where the capsular polysaccharides of two of serotypes 1, 3, and 5 and one or both of serotypes 15B and 22F are conjugated to TT and the remaining capsular polysaccharides are conjugated to CRM197. Also provided are methods of producing the mixed carrier, multivalent pneumococcal conjugate compositions and methods of using the same for prophylaxis against Streptococcus pneumoniae infection or disease in a subject.

公开(公告)号：US20180177861A1

公开(公告)日：2018-06-28

申请号：US15738417

申请日：2016-06-23

申请人： Sanofi Pasteur, Inc.

发明人： Carlos DiazGranados ,  Andrew Dunning

IPC分类号： A61K39/145 ,  C12N7/00 ,  A61P29/00

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/545 ,  A61K2039/70 ,  A61P29/00 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16134 ,  C12N2760/16234 ,  Y02A50/478

摘要： This application relates to the field of prevention of pneumonia by administration of a high-dose influenza vaccine.

公开(公告)号：US20180110849A1

公开(公告)日：2018-04-26

申请号：US15573351

申请日：2016-05-14

申请人： Sanofi Pasteur, Inc.

发明人： Laurence Quemeneur ,  Patricia Pietrobon ,  Patricia Ladono-Hayes ,  Steven HAUSER

IPC分类号： A61K39/08

CPC分类号： A61K39/08 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/575

摘要： The disclosure relates to generally to the field of therapeutic and/or protective vaccination against Clostridium dificile (C. difficile). More specifically, it relates to methods for immunizing a host against C. difficile strains expressing C. difficile binary toxin (CDT) and strains not expressing CDT. These methods involve the administration to a host of an immunogenic composition comprising inactivated purified C. difficile Toxin A and purified Toxin B. The purified C. difficile toxins may be derived from a C. difficile strain that does not express CDT.

公开(公告)号：US09844601B2

公开(公告)日：2017-12-19

申请号：US14855994

申请日：2015-09-16

申请人： Sanofi Pasteur Inc.

发明人： Robert P. Ryall

IPC分类号： A61K39/095 ,  A61K47/48 ,  A61K47/08 ,  A61K47/02 ,  A61K39/39 ,  A61K39/116 ,  A61K47/24 ,  A61K47/61 ,  A61K47/64 ,  A61K39/00

CPC分类号： A61K47/64 ,  A61K39/095 ,  A61K39/116 ,  A61K39/39 ,  A61K47/02 ,  A61K47/08 ,  A61K47/24 ,  A61K47/61 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70

摘要： The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacteria Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains in children as well as adults.