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1.发明申请公开(公告)号：US20180028442A1
公开(公告)日：2018-02-01
申请号：US15616103
申请日：2017-06-07
申请人： TargaGenix, Inc. , The Research Foundation for the State University New York , Northeastern University
IPC分类号： A61K9/107 , A61K31/337 , A61K9/51 , A61K47/12
CPC分类号： A61K9/1075 , A61K9/51 , A61K31/337 , A61K47/12 , A61K47/44
摘要： A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.
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公开(公告)号：US07826640B1
公开(公告)日：2010-11-02
申请号：US12111566
申请日：2008-04-29
申请人： Jian Yao , ZhongFei (Mark) Zhang
发明人： Jian Yao , ZhongFei (Mark) Zhang
CPC分类号： G06K9/342 , G06K9/4652
摘要： There is provided a hierarchical shadow detection system for color aerial images. The system performs well with highly complex images as well as images having different brightness and illumination conditions. The system consists of two hierarchical levels of processing. The first level involves, pixel level classification, through modeling the image as a reliable lattice and then maximizing the lattice reliability using the EM algorithm. Next, region level verification, through further exploiting the domain knowledge is performed. Further analyses show that the MRF model based segmentation is a special case of the pixel level classification model. A quantitative comparison of the system and a state-of-the-art shadow detection algorithm clearly indicates that the new system is highly effective in detecting shadow regions in an image under different illumination and brightness conditions.
摘要翻译： 提供了一种用于彩色航空图像的分层阴影检测系统。 该系统对高度复杂的图像以及具有不同亮度和照明条件的图像表现良好。 该系统由两个层次级别的处理组成。 第一级涉及像素级别分类，通过将图像建模为可靠的格子，然后使用EM算法最大化格点可靠性。 接下来，通过进一步利用域知识进行区域级验证。 进一步的分析表明，基于MRF模型的分割是像素级分类模型的特例。 系统和最先进的阴影检测算法的定量比较清楚地表明，新系统在不同照明和亮度条件下检测图像中的阴影区域是非常有效的。
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公开(公告)号：US20210088699A1
公开(公告)日：2021-03-25
申请号：US15948475
申请日：2018-04-09
申请人： Ngwe Thawdar , Michael Medley , The Research Foundation for The State University New York , The Research Foundation of CUNY
摘要： A plasmonic phase modulator is provided. The modulator has a conductive layer, and a dielectric layer disposed on the conductive layer. A plasmonic layer is disposed on the dielectric layer. A plasmonic layer is disposed on the dielectric layer. The plasmonic layer is conductive to surface plasmon polariton (SPP) waves. The plasmonic layer may be, for example, a graphene sheet. A voltage signal source is operatively connected between the conductive layer and the plasmonic layer for modulating a propagation speed of an SPP wave propagating on the plasmonic layer.
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公开(公告)号：US20160129017A1
公开(公告)日：2016-05-12
申请号：US14900719
申请日：2014-07-01
发明人： William G. KERR , Sonia IYER
IPC分类号： A61K31/575 , A61K31/568 , A61K31/4709 , A61K31/5685 , A61K31/473 , A61K31/4045 , C12N15/113 , A61K31/655
CPC分类号： A61K31/575 , A61K31/4045 , A61K31/4709 , A61K31/473 , A61K31/565 , A61K31/566 , A61K31/568 , A61K31/5685 , A61K31/655 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2310/141
摘要： The present invention relates to the use of SHIP1 inhibitors and pan-SHIP1/2 inhibitors in various methods, including, without limitation: (i) a method to treat obesity or reduce body fat of an obese subject; (ii) a method to limit bone development in a subject suffering from an osteopetrotic or sclerotic disease; (iii) a method to treat or prevent diabetes; (iv) a method to reduce glucose intolerance or insulin resistance; and (v) a method to lower cholesterol.
摘要翻译： 本发明涉及SHIP1抑制剂和pan-SHIP1 / 2抑制剂在各种方法中的应用，包括但不限于：（i）一种治疗肥胖或降低肥胖受试者体重的方法; （ii）限制患有骨质疏松症或硬化性疾病的受试者的骨发育的方法; （iii）治疗或预防糖尿病的方法; （iv）降低葡萄糖不耐受或胰岛素抵抗的方法; 和（v）降低胆固醇的方法。
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5.发明申请SYSTEM, METHOD, AND COMPUTER ACCESSIBLE MEDIUM FOR VOLUMETRIC TEXTURE ANALYSIS FOR COMPUTER AIDED DETECTION AND DIAGNOSIS OF POLYPS 审中-公开系统，方法和计算机可访问媒体用于计算机辅助检测和POLYPS诊断的体积纹理分析公开(公告)号：US20150065868A1
公开(公告)日：2015-03-05
申请号：US14390212
申请日：2013-03-15
发明人： Jerome Zheng Liang , Hongbing Lu , Guopeng Zhang
CPC分类号： G06T7/0012 , A61B1/00009 , A61B1/31 , A61B5/4255 , A61B6/032 , A61B6/12 , A61B6/5229 , G06T7/64 , G06T2200/04 , G06T2207/10072 , G06T2207/10081 , G06T2207/20076 , G06T2207/20081 , G06T2207/30032
摘要： A computer-based method for diagnosing a region of interest within an anatomical structure having the steps of receiving a 3D volumetric representation of the anatomical structure, and identifying at least one volume of interest and volume of normal of the anatomical structure. A first feature set can be generated based on a density, a gradient and a curvature of the volume of interest, and the first feature set can be compared to a second feature set to diagnose the region of interest to at least one a plurality of pathology types.
摘要翻译： 一种用于诊断解剖结构内的感兴趣区域的基于计算机的方法，其具有接收解剖结构的3D体积表示的步骤，以及识别解剖结构的正常的至少一个体积的体积和体积。 可以基于感兴趣体积的密度，梯度和曲率来生成第一特征集合，并且可以将第一特征集合与第二特征集进行比较，以将感兴趣区域诊断为至少一个多个病理学 类型。
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公开(公告)号：US10206875B2
公开(公告)日：2019-02-19
申请号：US15616103
申请日：2017-06-07
申请人： TargaGenix, Inc. , The Research Foundation for the State University of New York , Northeastern University
IPC分类号： A61K9/107 , A61K31/337 , A61K9/51 , A61K47/12 , A61K47/44
摘要： A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water nanoemulsion (NE) drug delivery system. A method of treating cancer by administering an effective amount of a pharmaceutical composition including a PUFA-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system to a subject in need of treatment, and treating cancer. A method of overcoming multidrug resistance by exposing a multidrug resistant cell to an effective amount of a pharmaceutical composition including an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate encapsulated in an oil-in-water NE drug delivery system, and inducing the death of the multidrug resistant cell. A method of eliminating a cancer stem cell. Methods of reducing stemness of a cancer stem cell, retaining drug in the body, and providing a slower release profile.
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公开(公告)号：US07826629B2
公开(公告)日：2010-11-02
申请号：US11335137
申请日：2006-01-19
CPC分类号： H04R23/008 , H04R23/006
摘要： A microphone having an optical component for converting the sound-induced motion of the diaphragm into an electronic signal using a diffraction grating. The microphone with inter-digitated fingers is fabricated on a silicon substrate using a combination of surface and bulk micromachining techniques. A 1 mm×2 mm microphone diaphragm, made of polysilicon, has stiffeners and hinge supports to ensure that it responds like a rigid body on flexible hinges. The diaphragm is designed to respond to pressure gradients, giving it a first order directional response to incident sound. This mechanical structure is integrated with a compact optoelectronic readout system that displays results based on optical interferometry.
摘要翻译： 一种麦克风，其具有用于使用衍射光栅将振动膜的声音引起的运动转换为电子信号的光学部件。 具有数字化指状物的麦克风使用表面和体微加工技术的组合在硅衬底上制造。 由多晶硅制成的1 mm×2 mm麦克风隔膜具有加强件和铰链支撑，以确保其在柔性铰链上像刚体一样响应。 隔膜设计用于响应压力梯度，给予其对入射声音的一级定向响应。 该机械结构与紧凑型光电读出系统集成，该系统基于光学干涉测量显示结果。
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8.发明申请Single-crystalline hematite rhombohedra and magnetic nanocomposites of iron and magnetite and methods of making same 审中-公开铁和磁铁矿的单晶赤铁矿菱磁和磁性纳米复合材料及其制备方法公开(公告)号：US20090090886A1
公开(公告)日：2009-04-09
申请号：US11973815
申请日：2007-10-09
申请人： Stanislaus S. Wong , Tae-Jin Park
发明人： Stanislaus S. Wong , Tae-Jin Park
CPC分类号： H01F1/0045 , B82Y25/00 , B82Y30/00 , C01G45/08 , C01G49/06 , C01P2004/03 , C01P2004/04 , C01P2004/54 , C01P2004/64 , C01P2006/42 , C01P2006/80 , C30B9/12 , C30B29/16
摘要： The present invention relates to nanostructures, in particular to hematite rhombohedra and iron/magnetite nanocomposites, and methods of making same.
摘要翻译： 本发明涉及纳米结构，特别涉及赤铁矿菱镁和铁/磁铁矿纳米复合材料及其制备方法。
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