公开(公告)号：US5035880A

公开(公告)日：1991-07-30

申请号：US563185

申请日：1990-08-06

申请人： Shigeki Mori ,  Naomi Yokosuka

发明人： Shigeki Mori ,  Naomi Yokosuka

IPC分类号： A61K8/00 ,  A61K8/40 ,  A61K8/49 ,  A61K8/86 ,  A61K8/90 ,  A61Q11/00

CPC分类号： A61K8/90 ,  A61K8/4926 ,  A61Q11/00

摘要： A dentifrice composition stably containing cetylpyridinium chloride and having improved shape retention at a low temperature in the form of an aqueous gel is disclosed. The composition comprises 15 to 80% by weight of a polyoxyethylene-polyoxypropylene block copolymer surfactant based on the total weight of the composition, 0.001 to 5% by weight of cetylpyridinium chloride based on the total weight of the composition, and polyethylene glycol having an average molecular weight of 2,000 to 20,000 in a proportion of 1/200 to 1/4 based on the weight of the polyoxyethylene-polyoxypropylene block copolymer.

公开(公告)号：US4818521A

公开(公告)日：1989-04-04

申请号：US933867

申请日：1986-11-24

申请人： Hiroshi Tamabuchi

发明人： Hiroshi Tamabuchi

IPC分类号： A61K8/06 ,  A61K8/67 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/135

CPC分类号： A61K8/062 ,  A61K8/06 ,  A61K8/676 ,  A61Q19/00 ,  A61K2800/52 ,  Y10S514/887 ,  Y10S514/938 ,  Y10S514/972

摘要： An emulsion cosmetic stably containing vitamin C which comprises a mixture of L-ascorbic acid or a fatty acid ester thereof and an oil, and conventional ingredients for the emulsion cosmetic.

摘要翻译： 稳定地含有维生素C的乳液化妆品，其含有L-抗坏血酸或其脂肪酸酯与油的混合物，以及乳液化妆品的常规成分。

公开(公告)号：US20080248124A1

公开(公告)日：2008-10-09

申请号：US11730746

申请日：2007-04-03

申请人： Toru Eguchi ,  Kenji Hasegawa

发明人： Toru Eguchi ,  Kenji Hasegawa

IPC分类号： A61K9/52 ,  A61K31/65 ,  A61P1/02 ,  A61K47/06

CPC分类号： A61K31/65 ,  A61K9/06 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5089

摘要： The present invention relates to a process for producing a pharmaceutical composition which can stably contain an active ingredient unstable against water and can sustained-release such the active ingredient for a long period of time by remaining at an administrated portion as well as a pharmaceutical composition produced by the same. Specifically, the present invention relates to a process for producing a pharmaceutical composition, comprising steps of: mixing and heating a first phase, prepared by mixing a polyhydric alcohol and a salt, and a second phase containing a water-soluble polymer under a reduced pressure, before evaporating substantially all water in the first phase by mixing and heating a mixture of first and second phases under a reduced pressure or after evaporating substantially all water in the first phase by mixing and heating the first phase under a reduced pressure; and adding a third phase containing an active ingredient unstable against water and mixing them to obtain the pharmaceutical composition, as well as a pharmaceutical composition produced the same.

摘要翻译： 本发明涉及一种药物组合物的制造方法，其能够稳定地含有对水不稳定的活性成分，并且可以通过在给药部位保持长时间地持续释放活性成分以及生成的药物组合物 同样的 具体地说，本发明涉及药物组合物的制造方法，其特征在于，包括以下步骤：将通过混合多元醇和盐制备的第一相和减压下含有水溶性聚合物的第二相混合加热 在通过在减压下混合和加热第一相和第二相的混合物或在第一相中基本上全部水蒸发之后，在减压下混合和加热第一相，在基本上蒸发第一相中的所有水之前， 并加入含有对水不稳定的活性成分并混合它们以获得药物组合物的第三相，以及制备该组合物的药物组合物。

公开(公告)号：USD383608S

公开(公告)日：1997-09-16

申请号：US51045

申请日：1996-02-29

申请人： Atsushi Yamamoto ,  Kazumi Oishi

设计人： Atsushi Yamamoto ,  Kazumi Oishi

公开(公告)号：US5303852A

公开(公告)日：1994-04-19

申请号：US993076

申请日：1992-12-18

申请人： Akitoshi Yamawaki ,  Kanetsugu Yoshiki

发明人： Akitoshi Yamawaki ,  Kanetsugu Yoshiki

IPC分类号： B65D35/22 ,  B05B11/00 ,  B65D83/00 ,  B65D37/00 ,  B65D5/42

CPC分类号： B65D83/0055 ,  B65D2231/001

摘要： A viscous liquid-dispensing container which allows almost all amount of the content thereof to be easily extracted. The container includes a liquid-dispensing section having a head and a shoulder, and inner and outer containers respectively connected with the shoulder. The liquid-dispensing section includes a first check valve for allowing only extraction of the liquid. The outer container includes a second check valve for allowing only introduction of the exterior air. The inner container for accommodating the viscous liquid has a upper sleeve and lower bag connected to the upper sleeve. The upper sleeve is relatively hard, while the lower bag is made of a flexible thin film. After a predetermined amount of liquid is extracted, the lower bag is inverted and invades into the upper sleeve depending on the reduction of the liquid in the inner container.

摘要翻译： 一种粘性液体分配容器，其允许几乎所有量的含量容易地提取。 容器包括具有头部和肩部的液体分配部分，以及分别与肩部连接的内部和外部容器。 液体分配部分包括仅允许液体提取的第一止回阀。 外容器包括仅允许引入外部空气的第二止回阀。 用于容纳粘性液体的内容器具有连接到上套筒的上套筒和下袋。 上套筒相对较硬，而下袋由柔性薄膜制成。 在提取预定量的液体之后，根据内部容器中的液体的减少，下部袋被倒置并侵入上部套筒。

公开(公告)号：US5137811A

公开(公告)日：1992-08-11

申请号：US459185

申请日：1989-12-29

申请人： Toshiyuki Tanaka ,  Hirohisa Suido ,  Masakazu Nakamura

发明人： Toshiyuki Tanaka ,  Hirohisa Suido ,  Masakazu Nakamura

IPC分类号： C12Q1/37

CPC分类号： C12Q1/37 ,  C12Q2337/12 ,  C12Q2337/30 ,  Y10S530/802

摘要： A method for diagnosing contraction or progress of periodontal diseases is carried and by determining periodontopathic bacteria specific aminopeptidase activity in a specimen by using as a substrate for the enzyme. The substrate is either or both compounds of the formula:X--Z--Arg--Y [1]wherein Arg is arginine residue; X is or an amino blocking group; Y is a color developing group attached to the C-terminal of Arg; and Z is an amino acid or peptide residue composed of 1 or 2 amino acids or their blocked derivatives, the C-terminal of which is attached to the N-terminal of Arg, andX'--Z'--Pro--Y' [2]wherein Pro is proline residue; X' is an amino blocking group; Y' is a color developing group attached to the C-terminal of Pro; and Z' is an amino acid or peptide residue composed of 0 to 4 amino acids or their blocked derivatives, the C-terminal of which is attached to the N-terminal of Pro.

摘要翻译： 用于诊断牙周病的收缩或进展的方法进行，并且通过使用酶作为底物来测定样品中的牙周病细菌特异性氨基肽酶活性。 底物是下式的化合物或下式：X-Z-Arg-Y [1]，其中Arg是精氨酸残基; X是或氨基封闭基团; Y是连接到Arg的C末端的显色组; Z是由1或2个氨基酸组成的氨基酸或肽残基或其封端衍生物，其C末端连接于Arg的N末端，X'-Z'-Pro-Y'[2 ]其中Pro为脯氨酸残基; X'是氨基封闭基团; Y'是连接到Pro的C端的彩色显影组; 并且Z'是由0至4个氨基酸组成的氨基酸或肽残基或其封闭的衍生物，其C末端连接到Pro的N末端。

公开(公告)号：US5131912A

公开(公告)日：1992-07-21

申请号：US618230

申请日：1990-11-21

申请人： Masashi Ehara ,  Akio Fukumashi

发明人： Masashi Ehara ,  Akio Fukumashi

IPC分类号： A61K8/00 ,  A61K8/20 ,  A61K8/22 ,  A61K8/24 ,  A61K8/36 ,  A61K8/365 ,  A61K8/368 ,  A61K8/44 ,  A61Q5/10

CPC分类号： A61Q5/10 ,  A61K8/19 ,  A61K8/20 ,  A61K8/22 ,  A61K8/24 ,  A61K8/36 ,  A61K8/361 ,  A61K8/365 ,  A61K8/44 ,  A61K2800/88 ,  A61Q5/12

摘要： Novel durable 2-part hair dyeing agents composed of a first agent comprising as essential components at least one compound that forms HCO.sub.3 --by dissociation in water, an alkali generating substantially no irritating odor and a dye for hair and having a pH of 8.2 to 9.0. and a second agent comprising as essential components hydrogen peroxide and a buffer solution and having a pH of 2.0 to 4.0, the weight ratio of the first agent and the second agent to be mixed being such that the pH of the mixture of the two is in a range of from 6.5 to 7.9. These 2-part hair dyeing agents require only a short dyeing time, create little damage to hair and no irritating or disagreeable odor and have high dyeing effect.

公开(公告)号：US5108735A

公开(公告)日：1992-04-28

申请号：US474110

申请日：1990-05-03

申请人： Hidehiko Ohtsuki ,  Sayuri Tanii ,  Satoko Ozawa

发明人： Hidehiko Ohtsuki ,  Sayuri Tanii ,  Satoko Ozawa

IPC分类号： A61K8/66 ,  A61Q11/00

CPC分类号： A61K8/66 ,  A61Q11/00

摘要： An oral composition comprising mutanase and, as surfactants, a N-acyl sarcosinate or a N-acyl-L-glutamate together with one or more of nonionic surfactants selected from the group consisting of polyoxyethylene sorbitol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene lanolin derivative, polyoxyethylene nonyl phenyl formaldehyde condensate, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil and polyethylene glycol fatty acid ester.

公开(公告)号：US4943431A

公开(公告)日：1990-07-24

申请号：US286638

申请日：1988-12-19

申请人： Masaki Awamura ,  Kazushi Yamamoto ,  Masashi Nanjo

发明人： Masaki Awamura ,  Kazushi Yamamoto ,  Masashi Nanjo

IPC分类号： A61K8/00 ,  A61K8/34 ,  A61K8/37 ,  A61K8/39 ,  A61K8/89 ,  A61K8/891 ,  A61Q5/00 ,  A61Q5/12 ,  C08L83/04

CPC分类号： A61K8/375 ,  A61K8/06 ,  A61K8/345 ,  A61K8/891 ,  A61Q5/00

摘要： An emulsified hair cosmetic providing excellent easy combing and a feeling of smoothness to hair and protecting hair against heat and brushing which comprises a dimethylsilicone rubber of the formula ##STR1## wherein R.sup.1 and R.sup.2 are methyl or hydroxyl; and n is an integer of 4000 to 9000, polyalcohol and nonionic surfactant.

公开(公告)号：US4920984A

公开(公告)日：1990-05-01

申请号：US108677

申请日：1987-10-15

申请人： Hiroshi Furumichi ,  Takao Makishima

发明人： Hiroshi Furumichi ,  Takao Makishima

IPC分类号： A63B71/08

CPC分类号： A63B71/085

摘要： A mouthpiece comprising an ethylene-vinyl acetate copolymer having a vinyl acetate content of from 12 to 33 wt %, and the process for producing the same comprising the steps of:preparing a thermoplastic elastic sheet material formed to be increased in thickness from one end to the other end;preparing a teeth impression cast of a user who is going to use a mouthpiece to be produced; andpressing said teeth impression cast against said thermoplastic elastic sheet material in a softened state so as to transfer a shape of said teeth of said user onto said thermoplastic elastic sheet material to thereby obtain a mouthpiece which is set to be thicker at a portion corresponding to a front teeth position than at a portion corresponding to a molar teeth position.