公开(公告)号：US20080248124A1

公开(公告)日：2008-10-09

申请号：US11730746

申请日：2007-04-03

申请人： Toru Eguchi ,  Kenji Hasegawa

发明人： Toru Eguchi ,  Kenji Hasegawa

IPC分类号： A61K9/52 ,  A61K31/65 ,  A61P1/02 ,  A61K47/06

CPC分类号： A61K31/65 ,  A61K9/06 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5089

摘要： The present invention relates to a process for producing a pharmaceutical composition which can stably contain an active ingredient unstable against water and can sustained-release such the active ingredient for a long period of time by remaining at an administrated portion as well as a pharmaceutical composition produced by the same. Specifically, the present invention relates to a process for producing a pharmaceutical composition, comprising steps of: mixing and heating a first phase, prepared by mixing a polyhydric alcohol and a salt, and a second phase containing a water-soluble polymer under a reduced pressure, before evaporating substantially all water in the first phase by mixing and heating a mixture of first and second phases under a reduced pressure or after evaporating substantially all water in the first phase by mixing and heating the first phase under a reduced pressure; and adding a third phase containing an active ingredient unstable against water and mixing them to obtain the pharmaceutical composition, as well as a pharmaceutical composition produced the same.

摘要翻译： 本发明涉及一种药物组合物的制造方法，其能够稳定地含有对水不稳定的活性成分，并且可以通过在给药部位保持长时间地持续释放活性成分以及生成的药物组合物 同样的 具体地说，本发明涉及药物组合物的制造方法，其特征在于，包括以下步骤：将通过混合多元醇和盐制备的第一相和减压下含有水溶性聚合物的第二相混合加热 在通过在减压下混合和加热第一相和第二相的混合物或在第一相中基本上全部水蒸发之后，在减压下混合和加热第一相，在基本上蒸发第一相中的所有水之前， 并加入含有对水不稳定的活性成分并混合它们以获得药物组合物的第三相，以及制备该组合物的药物组合物。

公开(公告)号：US5223404A

公开(公告)日：1993-06-29

申请号：US639742

申请日：1991-01-11

申请人： Hirohisa Suido ,  Akira Miike ,  Kenji Hasegawa ,  Norihiko Kayahara ,  Toru Eguchi ,  Toshio Tatano ,  Koichi Nakashima

发明人： Hirohisa Suido ,  Akira Miike ,  Kenji Hasegawa ,  Norihiko Kayahara ,  Toru Eguchi ,  Toshio Tatano ,  Koichi Nakashima

IPC分类号： C12Q1/26 ,  C12Q1/37

CPC分类号： C12Q1/26 ,  C12Q1/37 ,  C12Q2334/00 ,  Y10S435/81 ,  Y10S530/802

摘要： A composition for testing periodontal diseases which diagnoses or prognosticates contraction or progress of the diseases or diagnoses the therapeutic value by promptly determining peptidase-like enzymatic activity in a specimen. The composition is a combination of a compound of the formula [1] or [2] or a mixture thereof, a chromogen and an oxidase:X-T-Pro-Y [1]orX'-Z'-Arg-Y' [2]wherein Pro is proline residue; Arg is arginine residue; X and X' are hydrogen or an amino protecting group, respectively; Y and Y' are a residue of a compound which can increase oxidation reaction rate of a chromogen with a oxidase in the presence of oxygen and is attached to the C-terminal of Pro or Arg, respectively; and T and Z' are an amino acid or peptide residue composed of 0 to 4 amino acids or their protected derivatives the C-terminal of which is attached to the N-terminal of Pro or Arg, respectively.

摘要翻译： 用于测定牙周疾病的组合物，其通过迅速测定样品中的肽酶样酶活性来诊断或预测疾病的收缩或进展或诊断治疗价值。 该组合物是式[1]或[2]的化合物或其混合物，色原和氧化酶：XT-Pro-Y [1]或X'-Z'-Arg-Y'[2 ]其中Pro为脯氨酸残基; Arg是精氨酸残基; X和X'分别为氢或氨基保护基; Y和Y'是化合物的残基，其可以在氧的存在下与氧化酶一起增加色原体的氧化反应速率，并分别连接到Pro或Arg的C-末端; 并且T和Z'是由0至4个氨基酸组成的氨基酸或肽残基或其C末端分别连接到Pro或Arg的N末端的受保护的衍生物。

公开(公告)号：US4983385A

公开(公告)日：1991-01-08

申请号：US250543

申请日：1988-09-29

申请人： Kenji Hasegawa ,  Nakashima Nakashima ,  Toru Eguchi ,  Ota Masako

发明人： Kenji Hasegawa ,  Nakashima Nakashima ,  Toru Eguchi ,  Ota Masako

IPC分类号： A61K9/06 ,  A61K9/00 ,  A61K47/00 ,  A61K47/32

CPC分类号： A61K9/006 ,  Y10S514/944 ,  Y10S514/969

摘要： An ointment base which comprises:(a) a hydrogel formed by a water-soluble polymer and a material selected from the group consisting of water, a polyhydric alcohol and a mixture thereof;(b) a methacrylate copolymer selected from a group consisting of dimethylaminoethyl methacrylate/methyl methacrylate copolymer, ethyl methacrylate/chlorotrimethylammonium ethyl methacrylate copolymer or a mixture thereof; and(c) a solubilizer which dissolves the methacrylate copolymer but is incompatible with water and the polyhydric alcohol,a weight ratio of the methacrylate copolymer to the solubilizer being 1:2-1:25.

摘要翻译： 一种软膏基质，其包含：（a）由水溶性聚合物形成的水凝胶和选自水，多元醇及其混合物的材料; （b）甲基丙烯酸酯共聚物，其选自甲基丙烯酸二甲基氨基乙酯/甲基丙烯酸甲酯共​​聚物，甲基丙烯酸乙酯/氯代三甲基铵甲基丙烯酸乙酯共聚物或其混合物; 和（c）溶解甲基丙烯酸酯共聚物但与水和多元醇不相容的增溶剂，甲基丙烯酸酯共聚物与增溶剂的重量比为1:2-1:25。

公开(公告)号：US08695628B2

公开(公告)日：2014-04-15

申请号：US13147343

申请日：2010-02-02

申请人： Hiroshi Komatsu ,  Motonobu Ito ,  Kazuhiro Yamanouchi ,  Kenji Hasegawa ,  Iwao Ito

发明人： Hiroshi Komatsu ,  Motonobu Ito ,  Kazuhiro Yamanouchi ,  Kenji Hasegawa ,  Iwao Ito

IPC分类号： F16K31/18

CPC分类号： E03F9/007 ,  Y10T137/7287 ,  Y10T137/7404

摘要： An opening/closing device 1 according to the present invention includes a gate 10 that receives a flow of a sewage W in an upright state, and can fall toward a downstream side of the flow and a first spring 52a that generates a force for bringing the gate 10 into an upright state, wherein the first spring 52 generates a force insufficient for bringing the gate 10 into the upright state if the gate 10 is in a fallen state, and generates a force sufficient for bringing the gate into the upright state if the gate 10 is tilted by an angle equal to or less than a predetermined angle.

摘要翻译： 根据本发明的打开/关闭装置1包括门10，其以直立状态接收污水W的流动并且可以朝向流动的下游侧落下;以及第一弹簧52a，其产生用于使 门10成为直立状态，其中如果门10处于下降状态，第一弹簧52产生不足以使门10进入直立状态的力，并产生足以使门处于直立状态的力，如果 门10倾斜一个等于或小于预定角度的角度。

公开(公告)号：US08561264B2

公开(公告)日：2013-10-22

申请号：US13576733

申请日：2010-02-03

申请人： Kenji Hasegawa ,  Makoto Momose ,  Hiroyuki Sugiyama

发明人： Kenji Hasegawa ,  Makoto Momose ,  Hiroyuki Sugiyama

IPC分类号： A44B1/18

CPC分类号： A44B17/0052 ,  A44B17/0023 ,  A44B17/0029 ,  A44B17/0076 ,  Y10T24/366 ,  Y10T24/3683 ,  Y10T24/3685 ,  Y10T24/45225

摘要： A female snap button detachably receives a projection of a male snap button in a projection-receiving space. The female snap button includes an annular protrusion rising from a base and defining the projection-receiving space. In the annular protrusion, there are formed thick-walled portions with the thickness from the inner surface of the protrusion to the radially outer side being relatively thick and thin-walled portions with the thickness being thinner than that in the thick-walled portions. The thick-walled portions and the thin-walled portions are arranged alternately in the circumferential direction.

摘要翻译： 母扣式按钮可拆卸地接收突出接收空间中的公扣扣的突起。 母扣式按钮包括从基座上升并限定突起接收空间的环形突起。 在环形突起中形成有从突起的内表面到径向外侧的厚度相对较厚的厚壁部分，其厚度比厚壁部分薄。 厚壁部分和薄壁部分沿圆周方向交替布置。

公开(公告)号：US08514581B2

公开(公告)日：2013-08-20

申请号：US12857463

申请日：2010-08-16

申请人： Kenji Hasegawa

发明人： Kenji Hasegawa

IPC分类号： H05K1/00

CPC分类号： H05K1/189 ,  H05K3/0064 ,  H05K2201/09036 ,  H05K2201/09063 ,  H05K2201/10189 ,  H05K2201/2009

摘要： According to one embodiment, a flexible printed wiring board includes a component mounting portion to which a component is mounted and to which a reinforcing sheet is bonded. The component mounting portion includes an inner layer comprising a wiring pattern, and an outermost film layer disposed to cover the wiring pattern. The outermost film layer, to which the reinforcing sheet is bonded, is formed with a groove such that, when the reinforcing sheet is bonded, the groove extends in a region between the outermost film layer and the reinforcing sheet and communicates with an outside of the region.

摘要翻译： 根据一个实施例，柔性印刷线路板包括部件安装部分，部件安装到该部件安装部分上，并且加强板被粘合到该部件安装部分。 部件安装部分包括包括布线图案的内层和设置成覆盖布线图案的最外面的薄膜层。 形成加强片的最外层膜形成有槽，使得当加强板粘合时，槽在最外膜层和加强板之间的区域中延伸，并与 地区。

公开(公告)号：US08513538B2

公开(公告)日：2013-08-20

申请号：US12957926

申请日：2010-12-01

申请人： Kenji Hasegawa

发明人： Kenji Hasegawa

IPC分类号： H05K1/11

CPC分类号： H05K1/0206 ,  H05K3/3421 ,  H05K2201/0959 ,  H05K2201/09663 ,  H05K2201/10689 ,  H05K2201/10969

摘要： According to one embodiment, a television apparatus includes a circuit board, a pad, a heat-transfer layer, and a block. The circuit board is mounted with an electronic component. The pad is provided on a surface of the circuit board. The heat-transfer layer is formed on the inner surface of a through hole in the circuit board. The through hole has an opening on the pad. The block contains a resin material and is located inside the heat-transfer layer to block the through hole.

摘要翻译： 根据一个实施例，电视设备包括电路板，垫，传热层和块。 电路板安装有电子元件。 焊盘设置在电路板的表面上。 传热层形成在电路板的通孔的内表面上。 通孔在垫上有一个开口。 该块包含树脂材料，并且位于传热层内部以阻挡通孔。

公开(公告)号：US20130117972A1

公开(公告)日：2013-05-16

申请号：US13812169

申请日：2010-07-26

申请人： Kenji Hasegawa ,  Makoto Momose ,  Hiroyuki Sugiyama

发明人： Kenji Hasegawa ,  Makoto Momose ,  Hiroyuki Sugiyama

IPC分类号： A44B1/06 ,  A44B1/08

CPC分类号： A44B1/06 ,  A44B1/08 ,  A44B1/185 ,  A44B1/42 ,  A44B17/0035 ,  A44B17/0041 ,  Y10T24/3611 ,  Y10T24/3613 ,  Y10T24/3615 ,  Y10T24/45042 ,  Y10T24/4556 ,  Y10T24/45916

摘要： A button fixing member made of synthetic resin, used to fix a button having a fixing opening to a cloth, the button fixing member including a plate-like base and a post protruding from the base to a front surface side of the base The post is deformed after it passes through the cloth and the fixing opening of the button when the button is fixed to the cloth. The post includes a cavity extending from an opening on a rear surface of the base to a closed end on the tip side of the post concentrically with the post, and a solid portion between the closed end of the cavity and the tip of the post. The axial length of the solid portion is set to be ⅕ or more of the length of the part of the post from the front surface of the base to the tip of the post.

摘要翻译： 一种由合成树脂制成的按钮固定构件，用于将具有固定开口的按钮固定到布上，按钮固定构件包括板状基部和从基部向基部的前表面侧突出的柱。该柱为 当按钮固定在布上时，它穿过布和按钮的固定开口后变形。 所述柱包括从所述基部的后表面上的开口延伸到所述柱的与所述柱同心的所述末端侧上的封闭端，以及所述腔的封闭端和所述柱的尖端之间的实心部分。 固体部分的轴向长度被设定为从基部的前表面到柱的尖端的柱的一部分的长度的1/5或更大。

公开(公告)号：US08432702B2

公开(公告)日：2013-04-30

申请号：US13032546

申请日：2011-02-22

申请人： Kenji Hasegawa ,  Tsuyoshi Kozai ,  Terunari Kanou

发明人： Kenji Hasegawa ,  Tsuyoshi Kozai ,  Terunari Kanou

IPC分类号： H05K5/02

CPC分类号： H05K1/02 ,  H05K1/0215 ,  H05K1/116 ,  H05K3/325 ,  H05K5/0247 ,  H05K7/142 ,  H05K9/0064 ,  H05K2201/09463 ,  H05K2201/10409

摘要： According to an aspect of the present invention, there is provided a printed wiring board including: a substrate including an edge and a fixing hole located adjacent to the edge, the fixing hole configured to receive a bolt; and a land formed in a vicinity of the fixing hole and extending in at least a first direction and a second direction, the first direction being a direction from the fixing hole toward a center of the substrate, the second direction being direction along the edge.

摘要翻译： 根据本发明的一个方面，提供了一种印刷线路板，包括：基板，其包括边缘和邻近边缘定位的固定孔，所述固定孔构造成接收螺栓; 以及形成在所述固定孔附近并且沿至少第一方向和第二方向延伸的台阶，所述第一方向是从所述固定孔朝向所述基板的中心的方向，所述第二方向是沿着所述边缘的方向。

公开(公告)号：US20130010231A1

公开(公告)日：2013-01-10

申请号：US13615659

申请日：2012-09-14

申请人： Daizaburo Matsuki ,  Katsuhiko Hayashi ,  Kenji Hasegawa ,  Hiroshi Yamaguchi

发明人： Daizaburo Matsuki ,  Katsuhiko Hayashi ,  Kenji Hasegawa ,  Hiroshi Yamaguchi

IPC分类号： G02F1/13357 ,  G09F13/04

CPC分类号： G02F1/133603 ,  G02B6/0058 ,  G02F1/133526 ,  G02F1/133605 ,  G02F1/133606

摘要： Provided is a backlight device having: a light source element having light emitting diodes and a lens expanding light from the light emitting diodes; a housing containing the light source element; a diffuser plate covering an opening portion of the housing; and a reflection sheet reflecting light emitted from the light source element, toward the diffuser plate. In the light source element, a plurality of the lenses are arranged at a central zone, the plurality of lenses being arranged in a plurality of rows.

摘要翻译： 提供一种背光装置，其具有：具有发光二极管的光源元件和从发光二极管扩展光的透镜; 包含所述光源元件的壳体; 覆盖所述壳体的开口部分的扩散板; 以及将从光源元件发射的光朝向扩散板反射的反射片。 在光源元件中，多个透镜布置在中心区域，多个透镜被布置成多行。