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118 条记录 (耗时 0.056 秒)

    Method and device for atrial cardioversion therapy
    2.
    发明授权
    Method and device for atrial cardioversion therapy 有权

    公开(公告)号：US11097120B2

    公开(公告)日：2021-08-24

    申请号：US16533355

    申请日：2019-08-06

    申请人： The Washington University

    发明人： Igor R. Efimov ,  Wenwen Li ,  Ajit Janardhan

    IPC分类号： A61N1/368 ,  A61N1/39 ,  A61N1/362

    摘要： Methods and apparatus for a three-stage atrial cardioversion therapy that treats atrial arrhythmias within pain tolerance thresholds of a patient. An implantable therapy generator adapted to generate and selectively deliver a three-stage atrial cardioversion therapy and at least two leads, each having at least one electrode adapted to be positioned proximate the atrium of the patient. The device is programmed for delivering a three-stage atrial cardioversion therapy via both a far-field configuration and a near-field configuration of the electrodes upon detection of an atrial arrhythmia. The three-stage atrial cardioversion therapy includes a first stage for unpinning of one or more singularities associated with an atrial arrhythmia, a second stage for anti-repinning of the one or more singularities, both of which are delivered via the far-field configuration of the electrodes, and a third stage for extinguishing of the one or more singularities delivered via the near-field configuration of the electrodes.

    Method for low-voltage termination of cardiac arrhythmias by effectively unpinning anatomical reentries
    3.
    发明授权
    Method for low-voltage termination of cardiac arrhythmias by effectively unpinning anatomical reentries 有权

    公开(公告)号：US10549108B2

    公开(公告)日：2020-02-04

    申请号：US16113692

    申请日：2018-08-27

    申请人： Washington University

    发明人： Igor R. Efimov ,  Valentin Krinski ,  Vladmir P. Nikolski

    IPC分类号： A61N1/36 ,  A61N1/39 ,  A61B5/0464 ,  A61N1/362 ,  A61B5/0402 ,  A61B5/00

    摘要： A method for extinguishing a cardiac arrhythmia utilizes destructive interference of the passing of the reentry wave tip of an anatomical reentry through a depolarized region created by a relatively low voltage electric field in such a way as to effectively unpin the anatomical reentry. Preferably, the relatively low voltage electric field is defined by at least one unpinning shock(s) that are lower than an expected lower limit of vulnerability as established, for example, by a defibrillation threshold test. By understanding the physics of the electric field distribution between cardiac cells, the method permits the delivery of an electric field sufficient to unpin the core of the anatomical reentry, whether the precise or estimated location of the reentry is known or unknown and without the risk of inducting ventricular fibrillation. A number of embodiments for performing the method are disclosed.

    Methods and devices for three-stage ventricular therapy
    5.
    发明授权
    Methods and devices for three-stage ventricular therapy 有权
    三级心室疗法的方法和装置

    公开(公告)号：US08874208B2

    公开(公告)日：2014-10-28

    申请号：US13349527

    申请日：2012-01-12

    申请人： Igor R. Efimov ,  Wenwen Li ,  Ajit Janardhan

    发明人： Igor R. Efimov ,  Wenwen Li ,  Ajit Janardhan

    IPC分类号： A61N1/368 ,  A61N1/39 ,  A61N1/362

    CPC分类号： A61N1/3906 ,  A61N1/3624 ,  A61N1/3918 ,  A61N1/395 ,  A61N1/3956 ,  A61N1/3981

    摘要： Methods and apparatus for a three-stage ventricular cardioversion and defibrillation therapy that treats ventricular tachycardia and fibrillation at low energy levels. An implantable therapy generator adapted to generate and selectively deliver a three-stage ventricular therapy and at least two leads operably each having at least one electrode adapted to be positioned proximate the ventricle of the patient. The device is programmed to deliver a three-stage therapy via both a far-field configuration and a near-field configuration of the electrodes upon detection of a ventricular arrhythmia. The three-stage therapy includes a first stage for unpinning of one or more singularities associated with the ventricular arrhythmia, a second stage for anti-repinning of the one or more singularities, both of which are delivered via the far-field configuration of the electrodes, and a third stage for extinguishing of the one or more singularities associated delivered via the near-field configuration of the electrodes.

    摘要翻译： 用于三级心室复律和除颤治疗的方法和装置，其以低能量水平治疗室性心动过速和颤动。 一种植入式治疗发生器，其适于产生和选择性地输送三级心室治疗，并且至少两个引线可操作地具有至少一个适于定位在患者的心室附近的电极。 该装置被编程为在检测到室性心律失常时通过远场配置和电极的近场配置进行三级治疗。 三级疗法包括用于解除与室性心律失常相关的一个或多个奇异点的第一阶段，一个或多个奇异点的抗再感染的第二阶段，两者均通过电极的远场配置递送 以及用于熄灭通过电极的近场配置传递的一个或多个奇异点的第三阶段。

    COLLAGEN MATRIX WITH LOCALLY CONTROLLED INTRAFIBRILLAR AND EXTRAFIBRILLAR MINERAL CONTENT AND METHODS OF PRODUCING
    6.
    发明申请
    COLLAGEN MATRIX WITH LOCALLY CONTROLLED INTRAFIBRILLAR AND EXTRAFIBRILLAR MINERAL CONTENT AND METHODS OF PRODUCING 有权
    具有本地控制的铁素体和非织造矿物含量的胶原基质和生产方法

    公开(公告)号：US20140221614A1

    公开(公告)日：2014-08-07

    申请号：US14169573

    申请日：2014-01-31

    申请人： The Washington University

    发明人： Lester Smith ,  Stavros Thomopoulos

    IPC分类号： C07K14/78

    CPC分类号： C07K14/78 ,  A61K38/39 ,  A61L27/12 ,  A61L27/24 ,  A61L27/46 ,  A61L2430/10 ,  C08L89/06

    摘要： A mineralized collagen matrix with an intrafibrillar and/or extrafibrillar gradient of mineralization for insertion replacement is disclosed. The intrafibrillar mineralization of the collagen matrix is formed by the addition of fetuin to the simulated body fluid. The gradient of intrafibrillar mineralization may stiffen the collagen matrix and simulate a natural insertion for improved cell infiltration and regeneration.

    摘要翻译： 公开了一种矿化胶原基质，其具有用于插入置换的矿化的原纤维和/或超原纤维梯度。 胶原基质的原纤维矿化通过将胎球蛋白加入到模拟体液中而形成。 原纤维矿化的梯度可以加强胶原基质，并模拟天然插入物以改善细胞浸润和再生。

    Use of chloroquine to treat metabolic syndrome
    10.
    发明授权
    Use of chloroquine to treat metabolic syndrome 有权
    使用氯喹治疗代谢综合征

    公开(公告)号：US08440695B2

    公开(公告)日：2013-05-14

    申请号：US12093198

    申请日：2006-10-31

    申请人： Michael B. Kastan ,  Clay F. Semenkovich ,  Jochen Schneider

    发明人： Michael B. Kastan ,  Clay F. Semenkovich ,  Jochen Schneider

    IPC分类号： A61K31/47

    CPC分类号： A61K31/4706 ,  A61K45/06 ,  Y02A50/411

    摘要： The present invention provides methods and compositions for modulating certain metabolic processes and for treating a variety of disorders associated with metabolic syndrome, including insulin related disorders, ischemia, oxidative stress, atherosclerosis, hypertension, obesity, abnormal lipid metabolism, and stroke by administering an effective dose of a chloroquine compound. The invention also provides methods and compositions relating to administering an effective dose of a chloroquine compound in combination with at least a second pharmaceutically active ingredient or compound including an antihyperglycemic diabetes treatment, an antihypertensive agent, an antithrombotic agent, and/or an inhibitor of cholesterol synthesis or absorption.

    摘要翻译： 本发明提供用于调节某些代谢过程和用于治疗与代谢综合征相关的多种疾病，包括胰岛素相关病症，缺血，氧化应激，动脉粥样硬化，高血压，肥胖，异常脂质代谢和中风的方法和组合物， 剂量的氯喹化合物。 本发明还提供了与至少第二药物活性成分或化合物组合施用有效剂量的氯喹化合物的方法和组合物，所述药物活性成分或化合物包括抗高血糖糖尿病治疗，抗高血压药，抗血栓形成剂和/或胆固醇抑制剂 合成或吸收。