公开(公告)号：US20250145719A1

公开(公告)日：2025-05-08

申请号：US19017160

申请日：2025-01-10

Applicant: Ono Pharmaceutical Co., Ltd. ,  Tokushima University

Inventor： Taku OKAZAKI ,  Daisuke Sugiura ,  Takeo Maeda ,  Shiro Shibayama

IPC: C07K16/28 ,  A61K39/00 ,  A61P37/06

Abstract: The present application provides an immunosuppressive agent containing a substance that is selected from anti-CD80 antibodies and anti-PD-L1 antibodies and that promotes binding between PD-L1 and PD-1.

公开(公告)号：US20250098642A2

公开(公告)日：2025-03-27

申请号：US18291989

申请日：2021-08-20

Applicant: JTEKT CORPORATION ,  TOKUSHIMA UNIVERSITY

Inventor： Masayuki TAKESHIMA ,  Yoshiyuki SHIBATA ,  Toshimasa SOKU ,  Kazuya NUMAZAKI ,  Fumiki MORIMATSU ,  Kentaroh TAKAGAKI ,  Maki HIRATA

IPC: A01K1/03 ,  A01K1/02 ,  A01K29/00

Abstract: A management system for an experimental animal is provided. This management system includes an information identifying unit configured to identify experimental information on the experimental animal to be transported to an experiment site, and a stress value calculating unit configured to calculate a stress value indicating stress to be suffered by the experimental animal during transportation based on the experimental information. The experimental information includes at least a part of a transportation distance for the transportation of the experimental animal, a transportation period for the transportation of the experimental animal, the number of the experimental animals to be transported at a time, an age of the experimental animal, and information on pretreatment given to the experimental animal prior to the transportation.

公开(公告)号：US12078590B2

公开(公告)日：2024-09-03

申请号：US17905486

申请日：2021-03-04

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Masaaki Nagase ,  Kouji Nishino ,  Nobukazu Ikeda

IPC: G01N21/3504 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/274 ,  G01N21/314 ,  G01N21/3504

Abstract: A concentration measurement method performed in a concentration measurement device including an electric unit having a light source and a photodetector, a fluid unit having a measurement cell through which a gas flows, and a processing circuit for calculating a concentration of the gas based on an intensity of a light passing through the measurement cell. The concentration measurement method includes a step of determining an absorption coefficient of the measurement gas using a reference absorption coefficient determined in association with the reference gas and a correction factor associated with the measurement gas, and a step of obtaining a concentration of the measurement gas flowing in the measurement cell using the absorption coefficient of the measurement gas. When the absorption peak wavelength of the measurement gas is longer than the peak wavelength of the light source, a reference gas having a longer absorption peak wavelength than the peak wavelength of the light source is used, and when the absorption peak wavelength of the measurement gas is shorter than the peak wavelength of the light source, a reference gas having a shorter absorption peak wavelength than the peak wavelength of the light source is used.

公开(公告)号：US20240287465A1

公开(公告)日：2024-08-29

申请号：US18662797

申请日：2024-05-13

Applicant: FUJIFILM Corporation ,  Tokushima University

Inventor： Kentaro NAKAMURA ,  Mitsuo SHIMADA ,  Tetsuya IKEMOTO

IPC: C12N5/071

CPC classification number: C12N5/0676 ,  C12N2500/38 ,  C12N2501/12 ,  C12N2501/16 ,  C12N2501/335 ,  C12N2506/1384

Abstract: An object of the present invention is to provide a method for producing insulin-producing cells having sufficient glucose responsiveness from mesenchymal stem cells, an insulin-producing cell having sufficient glucose responsiveness, a cell structure containing the insulin-producing cell, and a pharmaceutical composition. According to the present invention, there is provided a method for producing an insulin-producing cell from a mesenchymal stem cell, including (a) a step of producing a cell structure by incubating a plurality of biocompatible macromolecular blocks and a plurality of mesenchymal stem cells, and (b) a step of culturing one or more of the mesenchymal stem cells before the incubation in the step (a), the mesenchymal stem cell in the incubation in the step (a), or the cell structure produced in the step (a) in a medium containing the GLP-1 receptor agonist, and (c) a step of culturing the cell structure obtained in the step (a) or the step (b) in a medium containing the water-soluble vitamin and the hepatocyte growth factor.

公开(公告)号：US20240000053A1

公开(公告)日：2024-01-04

申请号：US18254484

申请日：2021-11-02

Applicant: JTEKT CORPORATION ,  Tokushima University

Inventor： Yasuhiro MURATA ,  Akihiro TAKAZATO ,  Shigekazu KAWAI ,  Nozomu MIURA ,  Takahito WATANABE ,  Taro MITO

IPC: A01K67/033

CPC classification number: A01K67/033

Abstract: There is provided a rearing apparatus including a hatching area that holds eggs of organisms to be reared and accommodates the organisms hatched from the eggs, and a rearing area that is defined in an area larger than the hatching area at a position different from the hatching area and in which the organisms are reared. The present disclosure provides a rearing apparatus that can implement high-density and large-scale rearing by effectively utilizing areas.

公开(公告)号：US20230022585A1

公开(公告)日：2023-01-26

申请号：US17780315

申请日：2020-11-27

Applicant: TOKUSHIMA UNIVERSITY

Inventor： Mikito YASUZAWA ,  Tsubasa MIKI ,  Yukihiro ARAKAWA ,  Yasushi IMADA ,  Hitoshi MATSUKI

IPC: C08F20/36 ,  C08J5/18 ,  A61L27/34 ,  C08F20/18 ,  A61L27/16

Abstract: An object is to provide a zwitterionic compound having an excellent protein adsorption inhibitory effect. The zwitterionic compound is a polymer comprising a unit represented by the following formula (1): wherein R1 is a hydrogen atom or a methyl group, R2 is OH or O−, X1 is —O— or —N(Q1)-, Q1 is a hydrogen atom or a C1-6 alkyl group, m is an integer of 1 to 12, and n is an integer of 1 to 4.

公开(公告)号：US20220364101A1

公开(公告)日：2022-11-17

申请号：US17623302

申请日：2020-07-03

Applicant: Tokushima University

Inventor： Kohji Itoh ,  Jun Tsukimoto

IPC: C12N15/52 ,  A61P3/00 ,  C12N15/86 ,  C12N9/48

Abstract: Provided are a modified-type neuraminidase, a gene encoding the modified-type neuraminidase, a combination of the modified-type neuraminidase and cathepsin A, a combination of the gene encoding the modified-type neuraminidase and a gene encoding cathepsin A, a vector including said genes, and a pharmaceutical composition containing same. The pharmaceutical composition can be used for the therapy of lysosomal storage disease.

公开(公告)号：US20220213576A1

公开(公告)日：2022-07-07

申请号：US17607397

申请日：2020-09-24

Applicant: TANAKA KIKINZOKU KOGYO K.K. ,  TOKUSHIMA UNIVERSITY

Inventor： Michimasa OKUBO ,  Kenji GOTO ,  Kunihiro TANAKA ,  Kojiro SHIRAISHI ,  Kunihiro SHIMA ,  Yuya KATO ,  Kenichi HAMADA ,  Eiichi HONDA ,  Emi TAKEGAWA

IPC: C22C5/02 ,  C22C1/02

Abstract: The present invention relates to a medical Au—Pt—Pd alloy including Au, Pt, Pd, and inevitable impurities. The alloy has an alloy composition inside a polygon (A1-A2-A3-A4-A5-A6) surrounded by straight lines connected at point A1 (Au: 37.9 atom %, Pt: 0.1 atom %, and Pd: 62 atom %), point A2 (Au: 79.9 atom %, Pt: 0.1 atom %, and Pd: 20 atom %), point A3 (Au: 79.9 atom %, Pt: 20 atom %, and Pd: 0.1 atom %), point A4 (Au: 69.9 atom %, Pt: 30 atom %, and Pd: 0.1 atom %), point A5 (Au: 49 atom %, Pt: 30 atom %, and Pd: 21 atom %), and point A6 (Au: 39 atom %, Pt: 40 atom %, and Pd: 21 atom %) in a Au—Pt—Pd ternary state diagram. The metal structure of the alloy is optimized, and the metal structure is close to a single-phase structure, and has little precipitation of a Au-rich phase and a Pt-rich phase different in composition from a mother phase.

公开(公告)号：US11377506B2

公开(公告)日：2022-07-05

申请号：US16762221

申请日：2018-11-14

Applicant: TOKUSHIMA UNIVERSITY ,  SEKISUI CHEMICAL CO., LTD.

Inventor： Koichi Ute ,  Tomohiro Hirano ,  Miyuki Oshimura ,  Yasunari Kusaka ,  Yohei Nishimura ,  Misaki Senoo

IPC: C08F8/14 ,  C08F216/06 ,  C08F218/08

Abstract: The present invention provides a vinyl alcohol-vinyl acetate copolymer having excellent solubility and capable of providing a film having high flexibility, high mechanical strength, and high adhesion, and a method for producing a vinyl alcohol-vinyl acetate copolymer. Provided is a vinyl alcohol-vinyl acetate copolymer including a unit of vinyl alcohol and a unit of vinyl acetate, the vinyl alcohol-vinyl acetate copolymer having a triad unit chain ratio TOO of 7.5 or less, where the triad unit chain ratio TOO is obtained using the following formula (1): [ Math . ⁢ 1 ] T OO = [ Vac ⁢ ⁢ content ] × [ OOO ⁢ ⁢ proportion ] × 2 [ VOH ⁢ ⁢ content ] × [ AOO ⁢ ⁢ proportion ] ( 1 ) wherein the VOH content ratio represents the amount of the unit of vinyl alcohol, the Vac content ratio represents the amount of the unit of vinyl acetate, the OOO proportion represents the proportion of a triad OOO, and the AOO proportion represents the proportion of a triad AOO.

公开(公告)号：US20210363520A1

公开(公告)日：2021-11-25

申请号：US16640521

申请日：2018-08-20

Applicant: Tokushima University

Inventor： Keishi Osakabe ,  Yuriko Osakabe

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/10

Abstract: Provided is a method for targeting a target nucleotide sequence. The method includes introducing, into a cell: (i) CRISPR type I-D related proteins Cas5d, Cas6d, and Cas7d, or nucleic acids encoding these proteins; and (ii) a guide RNA which includes a sequence complementary to said target nucleotide sequence and common repetitive sequences derived from CRISPR gene locus before and after said complementary sequence, or a DNA, encoding said guide RNA.