公开(公告)号：US11041807B2

公开(公告)日：2021-06-22

申请号：US15754948

申请日：2016-08-22

申请人： The United States of America, as Represented by the Secretary, Depart. of Health and Human Services

发明人： Hari Shroff ,  Yicong Wu

IPC分类号： G01N21/64 ,  G02B21/00 ,  G02B21/16 ,  G02B21/36

摘要： Various embodiments of a multi-photon microscopy system that uses sequential excitation of a sample through three or more objective lenses oriented at different axes intersecting the sample are disclosed. Each objective lens is capable of focused sequential excitation of the sample that elicits fluorescence emissions from the excited sample, which is then simultaneously detected by each respective objective lens along a respective longitudinal axis every time the sample is illuminated through only a single objective lens.

公开(公告)号：US20240173399A1

公开(公告)日：2024-05-30

申请号：US18275925

申请日：2022-02-04

申请人： The United States of America, as represented by the Secretary, Depart. of Health and Human Services

发明人： Jay A. Berzofsky ,  Yongjun Sui

IPC分类号： A61K39/215 ,  A61K31/713 ,  A61K38/20 ,  A61K39/00 ,  C12N15/117

CPC分类号： A61K39/215 ,  A61K31/713 ,  A61K38/2086 ,  C12N15/117 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2770/20034

摘要： Immunogenic compositions that include SARS-CoV-2 spike (S) protein, S1 protein, or S2 protein, and an adjuvant, such as alum, or a combination of CpG oligodeoxynucleotide, Poly I:C, and IL-15, and nanoparticle compositions that include SARS-CoV-2 S protein, S1 protein, or S2 protein, and CpG oligonucleotide, poly(I:C), and IL-15, are provided. Also provided are methods of using such compositions, for example a prime intramuscular administration followed by one or more intranasal boosters that include the disclosed nanoparticles, to generate an immune response to SARS-CoV-2 in a subject, for example respiratory mucosal immunity, for example to prevent SARS-CoV-2 infection or transmission to other subjects.

公开(公告)号：US10239830B2

公开(公告)日：2019-03-26

申请号：US15549743

申请日：2016-02-11

申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Samarjit Patnaik ,  Mercedes Taylor ,  Raul Rolando Calvo ,  Juan Jose Marugan ,  Noel Southall ,  Wei Zheng ,  Marc Ferrer-Alegre ,  Seameen Dehdasthi ,  Patricia Dranchak ,  Fannie Chen ,  Yiannis Ioannou

IPC分类号： C07C311/21 ,  A61K31/4164 ,  A61K31/44 ,  C07D207/335 ,  C07D213/46 ,  C07D233/64 ,  A61K31/165

摘要： Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides. A genus of suitable compounds is shown in formula 1: