中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

1049 records (took 0.136 seconds)

    VirB10 for vaccination against gram negative bacteria
    2.
    发明授权
    VirB10 for vaccination against gram negative bacteria 有权

    公开(公告)号：US12186381B2

    公开(公告)日：2025-01-07

    申请号：US17142792

    申请日：2021-01-06

    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

    Inventor： Anthony F. Barbet ,  Francy L. Crosby

    IPC: A61K39/02 ,  A61P31/04

    Abstract: The invention pertains to the use of VirB10 to immunize a host against an infection by a bacterium having T4SS. The invention provides a vaccine comprising VirB10, a fragment of VirB10, a polynucleotide encoding VirB10 or a polynucleotide encoding a fragment of VirB10 and a pharmaceutically acceptable carrier and/or adjuvant. The invention also provides a method of immunizing a host against an infection caused by a bacterium having T4SS, the method comprising administering to the host a vaccine of the invention. The vaccines and the methods of the invention can be used to immunize against infections caused by bacteria having T4SS in dogs, rabbits, cats, pigs, cattle, sheep, goats, deer, horses, rodents and humans.

    TRANSFORMER IMPEDANCE BALANCED CIRCUIT FOR POWER CONVERTERS
    3.
    发明申请
    TRANSFORMER IMPEDANCE BALANCED CIRCUIT FOR POWER CONVERTERS 有权

    公开(公告)号：US20250007413A1

    公开(公告)日：2025-01-02

    申请号：US18742232

    申请日：2024-06-13

    Applicant: University of Florida Research Foundation, Incorporated

    Inventor： Shuo Wang ,  Qinghui Huang

    IPC: H02M3/335 ,  H02M1/44

    Abstract: Impedance balancing of isolated converters to reduce common mode (CM) electromagnetic interference (EMI) noise over a wide frequency range. An impedance balanced isolator converter circuit comprises a plurality of resistor, inductor, and capacitor (RLC) branches (i) that are representative of a transformer circuit component, (ii) that are coupled in series with a plurality of respective noise source voltages, and (iii) comprise RLC parameters that are based on respective ones of a plurality of impedances associated with the transformer circuit component; a load impedance branch (i) that is representative of one or more transformer primary side circuit components and (ii) that is coupled in parallel with the plurality of RLC branches and the plurality of respective noise source voltages; and an RLC balance branch coupled in parallel with a first resistor, a first inductor, and a first capacitor that are associated with a first of the plurality of RLC branches.

    SYSTEM, METHOD, AND APPARATUS FOR DETECTING CALL INTERCEPTION
    4.
    发明申请
    SYSTEM, METHOD, AND APPARATUS FOR DETECTING CALL INTERCEPTION 有权

    公开(公告)号：US20240422545A1

    公开(公告)日：2024-12-19

    申请号：US18334765

    申请日：2023-06-14

    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

    Inventor： Patrick G. TRAYNOR ,  Kevin BUTLER ,  Christian PEETERS ,  Tyler TUCKER

    IPC: H04W12/12

    Abstract: Methods described herein relate to identifying an audio rogue base station intercept of a call using a modified distance bounding algorithm. Methods may include: establishing a shared resource for a session with a remote end device; selecting a nonce and provide the nonce to the remote end device; generating a sequence of bits; dividing the sequence of bits into a predetermined number of sub-sequences; performing a bit exchange with the remote end device using dual tone multi-frequency (DTMF) tones; determining, from the bit exchange, an average time of transmission; and identifying the presence or absence of an adversary intercepting the session.

    Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor...
    9.
    发明公开
    Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor... 审中-公开

    公开(公告)号：US20240293398A1

    公开(公告)日：2024-09-05

    申请号：US16486223

    申请日：2018-02-16

    Applicant: University of Florida Research Foundation, Incorporated

    Inventor： Matthew D. Disney ,  Sai Pradeep Velagapudi

    IPC: A61K31/496 ,  A61P35/00 ,  C07D235/18 ,  C12N15/10

    CPC classification number: A61K31/496 ,  A61P35/00 ,  C07D235/18 ,  C12N15/1065

    Abstract: RNA drug targets are pervasive in cells but methods to design small molecules that target them are sparse. Herein, we report a general approach to score the affinity and selectivity of RNA motif-small molecule interactions identified via selection. Named High Throughput Structure-Activity Relationships Through Sequencing (HiT-StARTS), HiT-StARTS is statistical in nature and compares input nucleic acid sequences to selected library members that bind a ligand via high throughput sequencing. The approach allowed facile definition of the fitness landscape of hundreds of thousands of RNA motif-small molecule binding partners. These results were mined against folded RNAs in the human transcriptome and identified an avid interaction between a small molecule and the Dicer nuclease-processing site in the oncogenic microRNA (miR)-18a hairpin precursor, which is a member of the miR-17-92 cluster. Application of the small molecule, Targapremir-18a, to prostate cancer cells inhibited production of miR-18a from the cluster, de-repressed serine/threonine protein kinase 4 protein (STK4), and triggered apoptosis. Profiling the cellular targets of Targapremir-18a via Chemical Cross Linking and isolation by Pull Down (Chem-CLIP), a covalent small molecule-RNA cellular profiling approach, and other studies showed specific binding of the compound to the miR-18a precursor, revealing broadly applicable factors that govern small molecule drugging of non-coding RNAs.

Patent Agency Ranking