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1.发明授权Sustained-released product comprising a combination of a non-opioid amine and a non-steroidal, anti-inflammatory drug 有权持续释放的产品包含非阿片样物质胺和非甾体抗炎药物的组合公开(公告)号：US09456985B2
公开(公告)日：2016-10-04
申请号：US14697891
申请日：2015-04-28
发明人： Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Sean B. Mahoney , Stephen M. Berge
IPC分类号： A61K9/20 , A61K31/44 , A61K31/19 , A61K31/13 , A61K31/135 , A61K31/46 , A61K31/485 , A61K31/138 , A61K31/192
CPC分类号： A61K9/2054 , A61K9/2013 , A61K31/13 , A61K31/135 , A61K31/138 , A61K31/19 , A61K31/192 , A61K31/46 , A61K31/485 , A61K2300/00
摘要： Sustained-release oral pharmaceutical compositions and methods of use, wherein the compositions are in a single dosage form and include an amine-containing compound (including salts thereof), a salt of a non-steroidal anti-inflammatory drug (NSAID), and a hydrophilic matrix.
摘要翻译： 持续释放的口服药物组合物和使用方法，其中所述组合物为单一剂型，并且包括含胺化合物（包括其盐），非甾体抗炎药（NSAID）的盐和 亲水基质。
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公开(公告)号：US08785426B1
公开(公告)日：2014-07-22
申请号：US14177765
申请日：2014-02-11
发明人： Harish K. Pimplaskar
IPC分类号： A61K31/565 , A61K31/568 , A61K31/56 , A61K47/32
CPC分类号： A61K31/568 , A61K9/0014 , A61K9/06 , A61K31/56 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32
摘要： Described are gel compositions containing active pharmaceutical ingredient such as testosterone, solvent, and thickener, the gel compositions being useful for transdermal administration of the active ingredient to a patient, and related methods. Certain embodiments of the gel composition specifically exclude Hsieh enhancer.
摘要翻译： 描述了含有活性药物成分如睾酮，溶剂和增稠剂的凝胶组合物，该凝胶组合物可用于向患者透皮施用活性成分，以及相关方法。 凝胶组合物的某些实施方案具体地排除了Hsieh增强剂。
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3.发明申请公开(公告)号：US20120252833A1
公开(公告)日：2012-10-04
申请号：US13496818
申请日：2009-12-31
申请人： Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Sean B. Mahoney , Stephen M. Berge
发明人： Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Sean B. Mahoney , Stephen M. Berge
IPC分类号： A61K31/192 , A61K31/439 , A61P25/08 , A61P25/06 , A61P11/14 , A61K31/485 , A61P29/00
CPC分类号： A61K9/2054 , A61K9/2013 , A61K31/13 , A61K31/135 , A61K31/138 , A61K31/19 , A61K31/192 , A61K31/46 , A61K31/485 , A61K2300/00
摘要： Sustained-release oral pharmaceutical compositions and methods of use, wherein the compositions are in a single dosage form and include an amine-containing compound (including salts thereof), a salt of a non-steroidal anti-inflammatory drug (NSAID), and a hydrophilic matrix.
摘要翻译： 持续释放的口服药物组合物和使用方法，其中所述组合物为单一剂型，并且包括含胺化合物（包括其盐），非甾体抗炎药（NSAID）的盐和 亲水基质。
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公开(公告)号：US5268181A
公开(公告)日：1993-12-07
申请号：US905785
申请日：1992-06-29
IPC分类号： A61K9/22 , A61K9/20 , A61K31/455 , A61K47/38 , A61K9/30
CPC分类号： A61K9/2013 , A61K31/455 , A61K9/2054 , Y10S514/824
摘要： The invention provides a therapeutic method to treat hyperlipidemia by administering to a human patient a single daily dose of a prolonged release dosage form of niacin, so that nocturnal cholesterol synthesis is effectively suppressed.
摘要翻译： 本发明提供了一种治疗高脂血症的治疗方法，其通过向人类患者施用单次日剂量的烟酸延长释放剂型，从而有效抑制夜间胆固醇合成。
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公开(公告)号：US20160310508A1
公开(公告)日：2016-10-27
申请号：US15081402
申请日：2016-03-25
发明人： Harish K. Pimplaskar
IPC分类号： A61K31/568 , A61K47/14 , A61K47/10 , A61K9/00 , A61K9/06
CPC分类号： A61K31/568 , A61K9/0014 , A61K9/06 , A61K31/56 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32
摘要： Described are gel compositions containing active pharmaceutical ingredient such as testosterone, solvent, and thickener, the gel compositions being useful for transdermal administration of the active ingredient to a patient, and related methods. Certain embodiments of the gel composition specifically exclude Hsieh enhancer.
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公开(公告)号：US09295675B2
公开(公告)日：2016-03-29
申请号：US14307085
申请日：2014-06-17
发明人： Harish K. Pimplaskar
IPC分类号： A61K31/568 , A61K47/32 , A61K31/56 , A61K9/00 , A61K9/06 , A61K47/10 , A61K47/14 , A61K47/22
CPC分类号： A61K31/568 , A61K9/0014 , A61K9/06 , A61K31/56 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/32
摘要： Described are gel compositions containing active pharmaceutical ingredient such as testosterone, solvent, and thickener, the gel compositions being useful for transdermal administration of the active ingredient to a patient, and related methods. Certain embodiments of the gel composition specifically exclude Hsieh enhancer.
摘要翻译： 描述了含有活性药物成分如睾酮，溶剂和增稠剂的凝胶组合物，该凝胶组合物可用于向患者透皮施用活性成分，以及相关方法。 凝胶组合物的某些实施方案具体地排除了Hsieh增强剂。
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公开(公告)号：US20150265544A1
公开(公告)日：2015-09-24
申请号：US14731444
申请日：2015-06-05
IPC分类号： A61K9/50 , A61K31/357 , A61K9/48
CPC分类号： A61K31/7048 , A61K9/4808 , A61K9/5042 , A61K9/5047 , A61K31/357
摘要： An extended-release topiramate capsule that includes a capsule shell containing a single population of coated particles; wherein each coated particle includes a core and a coating thereon; wherein each particle core includes a homogeneous mixture comprising topiramate throughout its core; and wherein the coating includes one or more release controlling agent(s).
摘要翻译： 一种延长释放托吡酯胶囊，其包含含有单一包衣颗粒群的胶囊壳; 其中每个涂覆的颗粒包括芯和其上的涂层; 其中每个颗粒核心包括均匀的混合物，其包含托吡酯整个其核心; 并且其中所述涂层包括一种或多种释放控制剂。
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公开(公告)号：US20030171407A1
公开(公告)日：2003-09-11
申请号：US10094004
申请日：2002-03-07
IPC分类号： A61K031/4439 , A61K031/426 , A61K031/366 , A61K031/401 , A61K031/225
CPC分类号： A61K45/06 , A61K31/366 , A61K31/64 , A61K2300/00
摘要： The invention provides a pharmaceutical composition which is a combination of an insulin-secretion stimulant and a HMG-CoA reductase inhibitor. Suitable insulin-secretion stimulants include the sulfonylurea drugs, and suitable HMG-CoA reductase inhibitors include the statin drugs. The composition may be formulated to provide extended-release characteristics of one or both of the active components. Also provided are methods for treating a diabetic patient using a combination of an insulin-secretion stimulant and a HMG-CoA reductase inhibitor. Practice of the methods of the invention may result in the administration of fewer dosages to the patient. The invention also provides a pharmaceutical composition which is a combination of an antihyperglycemic drug, particularly a biguanide compound, in combination with a HMG-CoA reductase inhibitor. Also provided are methods for treating a diabetic patient using a combination of an antihyperglycemic biguanide compound and a HMG-CoA reductase inhibitor.
摘要翻译： 本发明提供了一种药物组合物，其是胰岛素分泌刺激剂和HMG-CoA还原酶抑制剂的组合。 合适的胰岛素分泌刺激剂包括磺酰脲类药物，合适的HMG-CoA还原酶抑制剂包括他汀类药物。 可以配制组合物以提供一种或两种活性组分的延长释放特性。 还提供了使用胰岛素分泌刺激剂和HMG-CoA还原酶抑制剂的组合治疗糖尿病患者的方法。 本发明方法的实践可能导致对患者施用较少的剂量。 本发明还提供了与HMG-CoA还原酶抑制剂组合的抗高血糖药物，特别是双胍化合物的组合的药物组合物。 还提供了使用抗高血糖双胍化合物和HMG-CoA还原酶抑制剂的组合治疗糖尿病患者的方法。
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9.发明申请Sustained Release Composition Comprising an Amine as Active Agent and a Salt of a Cyclic Organic Acid 审中-公开包含作为活性剂的胺和环状有机酸的盐的持续释放组合物公开(公告)号：US20160051475A1
公开(公告)日：2016-02-25
申请号：US14851253
申请日：2015-09-11
IPC分类号： A61K9/20 , A61K31/135 , A61K31/485
CPC分类号： A61K9/2013 , A61K9/2054 , A61K31/135 , A61K31/137 , A61K31/192 , A61K31/485
摘要： The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an amine-containing compound (e.g., an opioid) (including salts thereof) and a pharmaceutically acceptable salt of a non-NSAID cyclic organic acid compound.
摘要翻译： 本发明提供持续释放的口服药物组合物和使用方法。 持续释放的口服药物组合物包括含有胺的化合物（例如阿片样物质）（包括其盐）和非NSAID环状有机酸化合物的药学上可接受的盐。
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公开(公告)号：US20160000672A1
公开(公告)日：2016-01-07
申请号：US14851203
申请日：2015-09-11
IPC分类号： A61K8/365 , A61K8/36 , A61K8/368 , A61K31/19 , A61K31/5375 , A61K8/31 , A61K8/34 , A61K8/73 , A61Q19/00 , A61K31/573
CPC分类号： A61K31/573 , A61K8/31 , A61K8/345 , A61K8/361 , A61K8/365 , A61K8/368 , A61K8/49 , A61K8/73 , A61K9/0014 , A61K31/19 , A61K31/535 , A61K31/5375 , A61K31/56 , A61K45/06 , A61K47/44 , A61K2800/524 , A61Q19/00 , A61Q19/007 , A61K2300/00
摘要： Dermatological compositions (methods of making and using) that include one or more anesthetic agents and/or one or more anti-inflammatory agents and/or a combination of ammonium, sodium, and potassium salts, preferably of an alpha-hydroxy acid.
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