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公开(公告)号：US12071636B2
公开(公告)日：2024-08-27
申请号：US17478023
申请日：2021-09-17
发明人： Robert E Briggs , Fred M Tatum
IPC分类号： C12N9/16 , A61K39/102 , C12N9/04 , A61K39/00
CPC分类号： C12N9/0006 , A61K39/102 , C12N9/16 , C12Y101/01022 , C12Y301/03029 , A61K2039/522 , A61K2039/552
摘要： The present invention provides novel attenuated Pasteurella multocida strains that may be used, in live or killed form, to formulate vaccines that are highly protective against P. multocida infection in bovines, other mammals, and in birds. The present invention also identifies the combination of nanP and hyaC gene mutations as key to the provision of such vaccines. When appropriately formulated, antigenic material of numerous other bovine pathogens may be combined with the live attenuated Pasteurella multocida strains, to make effective combination vaccines.
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公开(公告)号：US12065658B2
公开(公告)日：2024-08-20
申请号：US16959928
申请日：2019-01-03
申请人： UWM Research Foundation, Inc. , United States of America, As Represented by the Secretary of Agriculture
发明人： Dazhong Zhao , Zhanguo Xin
IPC分类号： C12N15/82
CPC分类号： C12N15/8289
摘要： Disclosed herein are nuclear male sterile sorghum mutants, three-component genetic constructs, and methods of using said mutants and genetic constructs, such as in a two-line male sterility system for hybrid breeding.
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公开(公告)号：US12064472B2
公开(公告)日：2024-08-20
申请号：US18318909
申请日：2023-05-17
发明人： Adalberto A. Perez De Leon , Robert Miller , Robert E. Briggs , Fred M. Tatum , Felicito Guerrero
CPC分类号： A61K39/0003 , A61K39/08 , A61P33/14 , C07K14/33 , C07K14/43527 , A61K2039/523 , A61K2039/53 , A61K2039/552 , C07K2319/00
摘要： This invention relates to novel fusion peptides and immunogenic compositions containing the fusion peptides useful in the control and prevention of tick infestations. The invention also relates to compositions comprising said fusion peptides, methods of vaccination against tick infestation using said fusion peptides and compositions, and kits for use with such compositions and methods.
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公开(公告)号：US20240264138A1
公开(公告)日：2024-08-08
申请号：US18106101
申请日：2023-02-06
发明人： WILLIAM M. IVERSEN
IPC分类号： G01N33/24
CPC分类号： G01N33/24
摘要： The hand carried enhanced penetrometer includes an electrical linear actuator system to advance a soil penetration rod into a test site soil during a penetrometer test. The penetrometer also includes a base plate system that uses an operator's static body weight to anchor the penetrometer to a test site surface during a penetrometer test. In operation, an operator places at least one foot on a penetrometer structural base plate and activates the linear actuator to advance a penetration rod into the test site soil. The tripod embodiment of the system includes an operator's seat that allows an operator to conduct a penetrometer test in a seated position while passively anchoring the penetrometer in place at the test site. The invention includes monopod, bipod, and tripod embodiments.
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公开(公告)号：US11981750B2
公开(公告)日：2024-05-14
申请号：US17938865
申请日：2022-10-07
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE L'ALIMENTATION ET L'ENVIRONNEMENT , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
发明人： John P. Bannantine , Gilles Etienne , Sylvie Bay , Franck Biet
CPC分类号： C07K5/0812 , A61K39/04 , A61K47/542 , A61K47/60 , C07K7/06 , C12Q1/689 , G01N33/5695 , G01N2333/5428 , G01N2333/57 , G01N2469/20 , G01N2800/26
摘要： The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map) S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.
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公开(公告)号：US11974548B2
公开(公告)日：2024-05-07
申请号：US16991522
申请日：2020-08-12
发明人： Sandra N. Leal
IPC分类号： A61D19/00 , A01K29/00 , A01K67/033
CPC分类号： A01K29/005 , A01K67/033 , A61D19/00
摘要： A method for determining the mated status of female fruit flies, focusing on determining the presence of spermatozoa in a sample fly's ventral receptacle (VR). The ventral receptacle is the organ where eggs become fertilized. The VR is the first and last organ in a mated female fly to contain spermatozoa. The VR is thus the most accurate organ for determining whether a female fruit fly has recently mated. The method is a squash method. The fly's ventral receptacle is isolated, and then squeezed so as to cause spermatozoa stored in the ventral receptacle to be released into the lumen of the VR. This permits use of a microscope to determine the presence or absence of spermatozoa in the female fruit fly, and thus the mated status of the female fruit fly.
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公开(公告)号：US20240033324A1
公开(公告)日：2024-02-01
申请号：US18346317
申请日：2023-07-03
CPC分类号： A61K38/1767 , C12N15/8216 , C12N15/8282 , C12N15/8205
摘要： Aspergillus flavus is an opportunistic, saprophytic fungus that infects maize and other fatty acid-rich food and feed crops and produces toxic and carcinogenic secondary metabolites known as aflatoxins. In vitro studies showed a five-fold increase in antifungal activity of AGM182 (vs. tachyplesin1) against A. flavus. Transgenic maize plants expressing AGM182 under maize Ubiquitin-1 promoter were produced through Agrobacterium-mediated transformation. PCR products confirmed integration of the AGM182 gene, while RT-PCR of maize RNA confirmed the presence of AGM182 transcripts. Maize kernel screening assay using a highly aflatoxigenic A. flavus strain (AF70) showed up to 72% reduction in fungal growth in the transgenic AGM182 seeds compared to isogenic negative control seeds.
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公开(公告)号：US11840499B2
公开(公告)日：2023-12-12
申请号：US17186958
申请日：2021-02-26
发明人： Helen N Lew , Xuetong Fan , Kun Huang , Jianwei Zhang
IPC分类号： A01N47/44 , C07C279/14
CPC分类号： C07C279/14 , A01N47/44
摘要： A biobased fatty acid arginate may be synthesized according to the disclosed process by combining arginine and a fatty acid. The fatty acid arginate may have certain beneficial properties, such as surfactant properties or acting as an antimicrobial agent.
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公开(公告)号：US20230329284A1
公开(公告)日：2023-10-19
申请号：US18303165
申请日：2023-04-19
发明人： JAY D. EVANS , YANPING CHEN , JAMES TAUBER , EVAN PALMER-YOUNG
IPC分类号： A23K50/90 , A23K20/163 , A61K31/724
CPC分类号： A23K50/90 , A23K20/163 , A61K31/724
摘要： The invention relates to compositions for reducing viral load in bees, the compositions comprising at least one plant secondary metabolite and a carrier comprising at least one sweetener, kits comprising such compositions, and methods of using such compositions to reduce viral load in bees.
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公开(公告)号：US20230309566A1
公开(公告)日：2023-10-05
申请号：US18331667
申请日：2023-06-08
申请人： The United States of America, as represented by the Secretary of Agriculture , OREGON STATE UNIVERSITY
发明人： MAN Y. CHOI , RUTH C. MARTIN , SEUNGJOON AHN , RORY MC DONNELL , SUJAYA RAO
CPC分类号： A01N63/50 , C07K7/06 , A01M1/2011 , C07K14/001 , C07K7/08
摘要： Provided herein are synthetic peptides developed from slug and insect neuropeptides. Peptides described can be used to repel, control or deter slugs, including the gray garden slug (Deroceras reticulatum), from feeding on agricultural and horticultural plants. The peptides can be combined with bait materials, or applied directly to plants or areas, or produced by genetically modified plants.
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