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1.发明申请公开(公告)号：US20200015741A1
公开(公告)日：2020-01-16
申请号：US16578298
申请日：2019-09-21
申请人： Vium, Inc.
发明人： Laura Schaevitz , Daniel J. Ford
摘要： A method of measuring efficacy of test treatment of an autoimmune disease in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals, a standard of care or a reference treatment for the first disease to determine efficacy of the test treatment. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Other embodiment uses a Fourier transform on a circle, LASSO, RANSAC or regression analyses for curve fitting. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.
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公开(公告)号：US10136612B1
公开(公告)日：2018-11-27
申请号：US15195956
申请日：2016-06-28
申请人： Vium, Inc
摘要： A modular vivarium is constructed entirely from transportable, sterile modules of distinct types, called pods. A hallway pod forms a spine, with cage-rack pods, ingress/egress pods and optional VHACPIT pods providing HVAC, power and IT services connected as spur pods to the hallway. Supplies and waste are also within modular pods. Temporary or single-use seals cover doorways during transit. Modules are joined or removed while maintaining sterility on both sides of the flush-to-wall doorway junction. Supply and return air for all pods is through hallway based ducting. Pods may be constructed from ISO intermodal containers. Embodiments have no permanent buildings. Pods may be moved, leveled and aligned for joining via special supports. Cage-rack pods are configured with two cage racks and a single isle permitting robotic cage placement and retrieval. Embodiments provide vibration, noise and earthquake isolation.
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公开(公告)号：US20180173915A1
公开(公告)日：2018-06-21
申请号：US15893659
申请日：2018-02-11
申请人： Vium, Inc.
CPC分类号： G06K7/1413 , G06K7/10366 , G06K19/06028 , G06K19/0614
摘要： An animal identification code is described comprising two numbers, one of which is encoded into a human-readable marking and the other of which is encoded into a machine-readable marking, where the two numbers and the two encodings are different. The combination of the two numbers, plus additional information not marked on a first animal, such as time of read, is looked up a first table to determine conditional validity and from there to a second table to determine a valid and unique animal ID associated with the animal, a primary key. The animal may be a rodent in a vivarium and the markings may be tattooed on the animal tail. The second marking may be a vine code with a spine where the spine is aligned with the animal tail. The first number may be unique within a first animal population such as an animal study. The combination of the first and second marking may be reused on a second animal wherein the lifetimes of the first and second animal do not overlap. The primary key is unique among all animals in a third population, dead or alive.
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公开(公告)号：US09986716B1
公开(公告)日：2018-06-05
申请号：US15169575
申请日：2016-05-31
申请人： Vium, Inc.
CPC分类号： A01K1/031 , A01K5/00 , A01K7/00 , A01K29/005 , G06K9/00771 , H04N7/183
摘要： An animal monitoring device and method comprising an animal cage and associated electronics slab is described. The device is suitable for use in a modular vivarium implemented in one or two racks adjacent to walls in a holding pod. There is a one-to-one relationship between fixed slabs and removable cages. A single camera provides range of functions: its field of view includes the entire area of the cage accessible to an animal; it may observe water level in a water bottle; it may observe food level in a food tray; it may view activity on an exercise device; it may read the rear of cage card. The shape of the food tray is specialized to meet these requirements. An inner-cage frame holds elements in fixed locations within the cage. The cage is free of electronic penetrations. Supply and return air for the cage passes through the slab.
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公开(公告)号：US20180121758A1
公开(公告)日：2018-05-03
申请号：US15338422
申请日：2016-10-30
申请人： Vium, Inc.
CPC分类号： G06K9/6255 , G06K9/00362 , G06K9/00885 , G06K9/52 , G06K9/6267 , G06K2209/01
摘要： A method of reading arbitrary symbols is described. Symbols may degrade over time. Shapes of symbols as they degrade are used to update an initial symbol library, which is created based on actual markings, rather than idealized symbols. Marks associate with shapes, which associate to symbols, which in aggregate associate with an object ID. A read mark is compared to all the shapes in the library to determine a most likely shape. A selection set is used to limit shape selection, based on the comparison, to shapes of valid symbols. Comparison methods use probability distributions. Confidence values are used to validate output, generate warnings, and to control updating of the library. Weighted averaging based on confidence values or age of reads may be used at the level of shapes, comparison distributions, or selections.
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公开(公告)号：US20180092596A1
公开(公告)日：2018-04-05
申请号：US15282364
申请日：2016-09-30
申请人： Vium, Inc.
发明人： Daniel J. Ford , Laura Schaevitz
摘要： A method of measuring efficacy of treatment of multiple sclerosis (MS) in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals or a standard of care to determine efficacy. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Another embodiment uses a Fourier transform on a circle and a linear combination. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.
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公开(公告)号：US20170105385A1
公开(公告)日：2017-04-20
申请号：US15396062
申请日：2016-12-30
申请人： Vium, Inc.
CPC分类号： A01K1/031 , A01K1/015 , G01G19/52 , G01G21/22 , G01G23/3728
摘要： An animal cage is described suitable for automated use in a vivarium. The cage comprises a study animal; bedding; pathogens; a wireless, a sterilizable scale comprising a sterile case comprising a flexible, penetrated membrane; and a penetrating fastener penetrating the membrane. The comprises four internal volume areas with respect to pathogen content: (1) volume between the membrane and a weighing platform, free of bedding; (2) a sterile volume inside the scale case below the membrane; (3) a vertical channel fluidly connecting the inside of the cage with the first volume; and (4) the inside of the cage outside of the above three volumes. These four volumes are sterilely isolated from air outside the cage. Electronics in the scale communicate wirelessly, through the cage, to cage-associated electronics outside the cage, using narrow beam communications free of device-ID specific protocol. The scale may be disassembled, sterilized in a fluid, re-assembled, and re-used in a different cage.
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公开(公告)号：US20200342188A1
公开(公告)日：2020-10-29
申请号：US16396659
申请日：2019-04-27
申请人： Vium, Inc.
摘要： A device and method of receiving RFID signals are described using a grid of transceivers driven to generate RF phase synchronous transmissions of RFID query messages, while each transceiver in the grid receives replies from individual RFIDs independently. The transceivers may be located in a planar array at the floor of an animal cage, while the RFIDs are implanted in animals in the cage. Additional transceivers may be located at the sides of the cage. Locations of individual animals in the cage are determined using a corresponding map of the locations of the transceivers.
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公开(公告)号：US10789432B2
公开(公告)日：2020-09-29
申请号：US15849519
申请日：2017-12-20
申请人： Vium Inc
发明人： Kyle Howard Heath , Daniel J. Ford , Youssef Barhomi , Pablo Jadzinsky , Jonathan Betts-LaCroix
摘要： The field of this invention is recording motion of an animal, uniquely identifying the animal, and recording an activity of that animal. Motions of animals on a path when the animal is or can be uniquely identified are tracklets. Tracklets begin and end at ambiguation events, where these are defined as locations and times of an animal where it cannot be uniquely identified. A first animal may be uniquely identified by first identifying all other animals in the first animal's environment. Animal identification may be after the end of a tracklet. Embodiments use optical flow analysis from video of an animal's environment. Embodiments record an animal's activity on tracklets and then use that activity to measure animal health or use that activity as data for a study using animals.
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公开(公告)号：US10596198B1
公开(公告)日：2020-03-24
申请号：US14871986
申请日：2015-09-30
申请人： Vium, Inc.
摘要： An apparatus for sequestering and releasing compounds into the air is provided. The apparatus includes a card with a first side and a second side, and a plurality of compound-sequestering structures affixed to the first side. Each of the plurality of compound-sequestering structures is configured to release a compound into the air when heated to a first temperature.
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