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    SEALANT COMPOSITIONS
    6.
    发明申请
    SEALANT COMPOSITIONS 审中-公开
    密封组合物

    公开(公告)号：US20160082145A1

    公开(公告)日：2016-03-24

    申请号：US14653862

    申请日：2013-12-20

    申请人： THROMBOTARGETS EUROPE, S.L.

    发明人： Juan Ramon RODRÍGUEZ FERNÁNDEZ - ALBA ,  Jesús MURAT MORENO

    IPC分类号： A61L24/04

    CPC分类号： A61L24/043 ,  A61L15/32 ,  A61L24/10 ,  A61L24/106 ,  A61L33/12 ,  A61L33/126

    摘要： The invention provides a combination comprising thrombin, fibrinogen, and lipidated tissue factor, as well as sealant compositions comprising thereof, and their use as a sealant agent as well as in the treatment of hemorrhages. The combination and compositions of the invention shows improved hemostatic properties and, at the same time, the quality of the clot formed is so consistent that the sealant efficiency is improved over those sealant compositions of the prior art.

    摘要翻译： 本发明提供包含凝血酶，纤维蛋白原和脂化组织因子的组合，以及包含它们的密封剂组合物，以及它们作为密封剂的用途以及治疗出血。 本发明的组合和组合物显示出改善的止血性能，同时，形成的凝块的质量是一致的，使得密封剂效率优于现有技术的密封剂组合物。

    DEVICE FOR THE REMOVAL OF THROMBI FROM BLOOD VESSELS
    8.
    发明申请
    DEVICE FOR THE REMOVAL OF THROMBI FROM BLOOD VESSELS 审中-公开
    从血管中去除血栓的装置

    公开(公告)号：US20110060359A1

    公开(公告)日：2011-03-10

    申请号：US12441960

    申请日：2007-09-20

    申请人： Ralf Hannes ,  Manuel Schneider ,  Holgar Pracht ,  Elina Miloslavski ,  Hermann Monstadt

    发明人： Ralf Hannes ,  Manuel Schneider ,  Holgar Pracht ,  Elina Miloslavski ,  Hermann Monstadt

    IPC分类号： A61F2/01

    CPC分类号： A61B17/22031 ,  A61B17/221 ,  A61B2010/0216 ,  A61B2017/22034 ,  A61B2017/22038 ,  A61B2017/22082 ,  A61B2017/22084 ,  A61B2017/320012 ,  A61B2090/397 ,  A61L33/126

    摘要： The invention relates to a device for the removal of foreign objects and thrombi from body cavities and blood vessels (12) using at least one guide wire (6, 7) provided with a distal element (2), said distal element (2) being provided with fibers (3) projecting radially outward and the device being provided with a cage (1) or tubular structure (16) which is suitable to be flatly collapsible under the external strain exerted by a micro-catheter (13) and transported inside the micro-catheter (13) and unfolds to its full cage (1) or tubular (16) structure when said external strain caused by the micro-catheter (13) is omitted, with said distal element (2) and the cage (1) or tubular (16) structure being designed so as to be longitudinally movable in relation to each other and the cage (1) or tubular structure (16) having an opening at the distal end through which the distal element (2) can be introduced into said cage (1) or tubular (16) structure. With the help of the inventive device thrombi (5) can be safely eliminated from blood vessels (12) in a simple manner.

    摘要翻译： 本发明涉及一种用于使用至少一个设置有远端元件（2）的导丝（6,7）从体腔和血管（12）中除去异物和血栓的装置，所述远端元件（2）是 设置有径向向外突出的纤维（3），并且所述装置设置有保持架（1）或管状结构（16），所述保持架（1）或管状结构（16）适于在由微导管（13）施加的外部应变下被平坦地折叠并在 当所述远端元件（2）和保持架（1）被省略，当微导管（13）引起的外部应变被省略时，微型导管（13）并展开到其全笼（1）或管状结构（16） 或管状（16）结构被设计成可以相对于彼此纵向移动，并且保持架（1）或管状结构（16）在远端具有开口，远端元件（2）可以通过该开口引入 所述笼（1）或管（16）结构。 借助于本发明的装置，血栓（5）可以以简单的方式从血管（12）中安全地消除。

    Fibrin coated polymer surfaces
    10.
    发明授权
    Fibrin coated polymer surfaces 失效
    纤维蛋白涂层聚合物表面

    公开(公告)号：US5272074A

    公开(公告)日：1993-12-21

    申请号：US872483

    申请日：1992-04-23

    申请人： Fraser D. Rubens

    发明人： Fraser D. Rubens

    IPC分类号： A61L27/00 ,  A61L27/34 ,  A61L33/00 ,  A61L33/12 ,  C12N11/08 ,  A01N1/02 ,  A61K37/547

    CPC分类号： A61L33/126 ,  A61L27/34 ,  Y10T436/10

    摘要： Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and prosthetic devices, and provide test systems useful in the study of thrombogenesis.

    摘要翻译： 聚合材料的表面涂有一层热变性纤维蛋白原。 纤维蛋白原可用凝血酶处理以产生纤维蛋白，并加入额外的纤维蛋白原和因子XIII以产生交联的纤维蛋白涂层。 所得涂层表面是稳定的，抗血栓形成的并且抗血小板粘附。 以这种方式涂覆的聚合材料可用于构建血管移植物和假体装置，并提供可用于研究血栓形成的测试系统。