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公开(公告)号：US20060105012A1
公开(公告)日：2006-05-18
申请号：US11261954
申请日：2005-10-28
申请人： Joseph Chinn , Stephen Chudzik , Sean Stucke
发明人： Joseph Chinn , Stephen Chudzik , Sean Stucke
CPC分类号： A61L31/10 , A61L27/34 , A61L33/0029 , A61L33/122 , C08L89/06
摘要： Pro-fibrotic coatings for medical articles are described that include a pro-fibrotic polymer such as collagen. The pro-fibrotic coatings can also include a thromboresistant polymer. The coatings can be formed by activation of photoreactive groups pendent or independent of the coating materials.
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公开(公告)号：US08535700B2
公开(公告)日：2013-09-17
申请号：US11261954
申请日：2005-10-28
CPC分类号： A61L31/10 , A61L27/34 , A61L33/0029 , A61L33/122 , C08L89/06
摘要： Pro-fibrotic coatings for medical articles are described that include a pro-fibrotic polymer such as collagen. The pro-fibrotic coatings can also include a thromboresistant polymer. The coatings can be formed by activation of photoreactive groups pendent or independent of the coating materials.
摘要翻译： 描述了用于医疗制品的原纤维化涂层，其包括前纤维化聚合物如胶原蛋白。 前纤维化涂层还可以包括抗血栓性聚合物。 可以通过活化侧基或独立于涂层材料的光反应性基团来形成涂层。
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3.发明授权Procedures for preparing composite materials from collagen and glycosaminoglycan 失效从胶原和糖胺聚糖制备复合材料的程序
公开(公告)号：US4350629A
公开(公告)日：1982-09-21
申请号：US287998
申请日：1981-07-29
IPC分类号： A61F2/00 , A61L27/24 , A61L27/26 , A61L33/00 , A61L33/12 , C08L89/06 , C07G7/00 , C08H1/00 , C08H1/06
CPC分类号： A61L33/122 , A61L27/24 , A61L27/26 , A61L33/0011 , C08L89/06 , A61F2310/00365 , Y10S128/08
摘要： This invention relates to crosslinked collagen and glycosaminoglycan materials, and to procedures for preparing such materials. It has been discovered that if collagen fibrils in an aqueous acidic solution are contacted with a crosslinking agent before being contacted with glycosaminoglycan, the materials produced have extremely low levels of thrombogenicity. Such materials are well suited for in-dwelling catheters, blood vessel grafts, and other devices that are in continuous contact with blood for long periods of time.
摘要翻译： 本发明涉及交联胶原和糖胺聚糖材料，以及制备这些材料的方法。 已经发现，如果将酸性水溶液中的胶原纤维在与糖胺聚糖接触之前与交联剂接触，则所生产的材料具有非常低的血栓形成水平。 这种材料非常适用于长时间与血液持续接触的住宅导管，血管移植物和其他装置。
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公开(公告)号：US08231930B2
公开(公告)日：2012-07-31
申请号：US12534937
申请日：2009-08-04
申请人： Dan Castro , Al Kuehn , Moon Hae Sunwoo
发明人： Dan Castro , Al Kuehn , Moon Hae Sunwoo
IPC分类号： A61L33/00
CPC分类号： A61L33/128 , A61F2310/00365 , A61L27/227 , A61L27/24 , A61L27/34 , A61L33/08 , A61L33/122 , C08L89/00 , C08L5/08 , C08L89/06
摘要： An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles.
摘要翻译： 本发明提供一种用于身体的植入物。 该可植入构件包括多孔生物相容性基底; 所述基材具有至少一个表面，其密封性与具有基本上相同直径范围的自聚集蛋白质颗粒密封。 自聚集的蛋白质颗粒由蛋白质颗粒的沉积的含水浆液形成。
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公开(公告)号：US20050085901A1
公开(公告)日：2005-04-21
申请号：US10951121
申请日：2004-09-27
申请人： Dan Castro , Al Kuehn , Moon Sunwoo
发明人： Dan Castro , Al Kuehn , Moon Sunwoo
CPC分类号： A61L33/128 , A61F2310/00365 , A61L27/227 , A61L27/24 , A61L27/34 , A61L33/08 , A61L33/122 , C08L89/00 , C08L5/08 , C08L89/06
摘要： An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles.
摘要翻译： 本发明提供一种用于身体的植入物。 该可植入构件包括多孔生物相容性基底; 所述基材具有至少一个表面，其密封液体与具有基本上相同直径范围的自聚集蛋白质颗粒密封。 自聚集的蛋白质颗粒由蛋白质颗粒的沉积的含水浆液形成。
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公开(公告)号：US5891192A
公开(公告)日：1999-04-06
申请号：US861994
申请日：1997-05-22
CPC分类号： A61L33/128 , A61B17/1215 , A61B17/12181 , A61L27/34 , A61L31/10 , A61L33/122 , A61L33/126 , A61B17/12022
摘要： Ion-implanted protein-coated occlusion coils are described which have essentially the same dimensions as untreated coils and exhibit altered surface properties, e.g., thrombogenicity, endothelial cellular migration and adhesion, relative to untreated coils thus making them particularly useful in treating wide-necked brain aneurysms.
摘要翻译： 描述了离子注入的蛋白质包被的闭塞线圈，其具有与未处理的线圈基本上相同的尺寸，并且相对于未处理的线圈表现出改变的表面性质，例如血栓形成，内皮细胞迁移和粘附，因此使得它们特别可用于治疗宽颈大脑 动脉瘤
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公开(公告)号：US07585319B2
公开(公告)日：2009-09-08
申请号：US10951121
申请日：2004-09-27
申请人： Dan Castro , Al Kuehn , Moon Hae Sunwoo
发明人： Dan Castro , Al Kuehn , Moon Hae Sunwoo
IPC分类号： A61F2/06
CPC分类号： A61L33/128 , A61F2310/00365 , A61L27/227 , A61L27/24 , A61L27/34 , A61L33/08 , A61L33/122 , C08L89/00 , C08L5/08 , C08L89/06
摘要： An implantable member for use in the body is provided herein. This implantable member includes a porous biocompatible substrate; the substrate having at least one surface sealed fluid-tight with self-aggregating protein particles of substantially the same diameter range. The self-aggregated protein particles are formed from a deposited aqueous slurry of the protein particles.
摘要翻译： 本发明提供一种用于身体的植入物。 该可植入构件包括多孔生物相容性基底; 所述基材具有至少一个表面，其密封液体与具有基本上相同直径范围的自聚集蛋白质颗粒密封。 自聚集的蛋白质颗粒由蛋白质颗粒的沉积的含水浆液形成。
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公开(公告)号：US07241309B2
公开(公告)日：2007-07-10
申请号：US09877867
申请日：2001-06-08
申请人： Dan Castro , Al Kuehn , Moon Hae Sunwoo
发明人： Dan Castro , Al Kuehn , Moon Hae Sunwoo
IPC分类号： A61F2/10
CPC分类号： A61L33/128 , A61F2310/00365 , A61L27/227 , A61L27/24 , A61L27/34 , A61L33/08 , A61L33/122 , C08L89/00 , C08L5/08 , C08L89/06
摘要： There is described a bio-compatible aqueous slurry for forming a fluid-tight barrier on a surface of a porous implantable article. This aqueous slurry includes a self-aggregating protein comminutate having a substantially uniform particle size, a bio-compatible plasticizer and water. This aqueous slurry is further characterized by having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25° C. and a pH sufficient to maintain the protein suspended in the slurry.
摘要翻译： 描述了用于在多孔可植入制品的表面上形成流体密封屏障的生物相容的含水浆料。 这种含水浆料包括具有基本上均匀粒度的自聚集蛋白质粉碎物，生物相容的增塑剂和水。 这种含水浆料的特征还在于在25℃下具有约8,000厘泊至约60,000厘泊的粘度，以及足以将蛋白质悬浮在浆料中的pH。
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公开(公告)号：US20020040247A1
公开(公告)日：2002-04-04
申请号：US09877867
申请日：2001-06-08
发明人： Dan Castro , Al Kuehn , Moon Hae Sunwoo
IPC分类号： A61F002/02
CPC分类号： A61L33/128 , A61F2310/00365 , A61L27/227 , A61L27/24 , A61L27/34 , A61L33/08 , A61L33/122 , C08L89/00 , C08L5/08 , C08L89/06
摘要： There is described a bio-compatible aqueous slurry for forming a fluid-tight barrier on a surface of a porous implantable article. This aqueous slurry includes a self-aggregating protein comminutate having a substantially uniform particle size, a bio-compatible plasticizer and water. This aqueous slurry is further characterized by having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25null C. and a pH sufficient to maintain the protein suspended in the slurry.
摘要翻译： 描述了用于在多孔可植入制品的表面上形成流体密封屏障的生物相容的含水浆料。 这种含水浆料包括具有基本上均匀粒度的自聚集蛋白质粉碎物，生物相容的增塑剂和水。 这种含水浆料的特征还在于在25℃下具有约8,000厘泊至约60,000厘泊的粘度，以及足以将蛋白质悬浮在浆料中的pH。
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公开(公告)号：US06177609B1
公开(公告)日：2001-01-23
申请号：US08814533
申请日：1997-03-10
申请人： Dan Castro , Al Kuehn , Moon Hae Sunwoo
发明人： Dan Castro , Al Kuehn , Moon Hae Sunwoo
IPC分类号： A61F210
CPC分类号： A61L33/128 , A61F2310/00365 , A61L27/227 , A61L27/24 , A61L27/34 , A61L33/08 , A61L33/122 , A61L27/54 , A61L27/502 , A61F2/06 , C08L89/06 , C08L89/00 , C08L5/08 , A61L33/0011 , A61L33/0052
摘要： There is described a bio-compatible aqueous slurry for forming a fluid-tight barrier on a surface of a porous implantable article. This aqueous slurry includes a self-aggregating protein comminutate having a substantially uniform particle size, a bio-compatible plasticizer and water. This aqueous slurry is further characterized by having a viscosity of about 8,000 centipoise to about 60,000 centipoise at 25° C. and a pH sufficient to maintain the protein suspended in the slurry.
摘要翻译： 描述了用于在多孔可植入制品的表面上形成流体密封屏障的生物相容的含水浆料。 这种含水浆料包括具有基本上均匀粒度的自聚集蛋白质粉碎物，生物相容的增塑剂和水。 这种含水浆料的特征还在于在25℃下具有约8,000厘泊至约60,000厘泊的粘度，以及足以将蛋白质悬浮在浆料中的pH。
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